Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates

Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA,...

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Detalhes bibliográficos
Autores: Mosquera Mosquera, Jesús, Sánchez López, Mateo Isidro, Valero, Julián, Mendoza, Javier de, Vázquez Sentís, Marco Eugenio, Mascareñas Cid, José Luis
Formato: artículo
Fecha de publicación:2015
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/12546
Acesso em linha:http://hdl.handle.net/10347/12546
Access Level:acceso abierto
Palavra-chave:Materias::Investigación::23 Química::2302 Bioquímica
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spelling Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugatesMosquera Mosquera, JesúsSánchez López, Mateo IsidroValero, JuliánMendoza, Javier deVázquez Sentís, Marco EugenioMascareñas Cid, José LuisMaterias::Investigación::23 Química::2302 BioquímicaConjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA, the oligoguanidinium unit also endows the conjugate with cell internalization propertiesRoyal Society of ChemistryUniversidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais MolecularesUniversidade de Santiago de Compostela. Departamento de Química Orgánica20152015-02-1820152015-02-18journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10347/12546reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Seventh Framework Programme 340055Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 SAF2013-41943-R HERRAMIENTAS SINTETICAS EN QUIMICA BIOLOGICA. NUEVAS ESTRATEGIAS MOLECULARES PARA EL TRATAMIENTO Y DIAGNOSTICO DE CANCERESopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/125462026-06-15T12:47:27Z
dc.title.none.fl_str_mv Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates
title Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates
spellingShingle Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates
Mosquera Mosquera, Jesús
Materias::Investigación::23 Química::2302 Bioquímica
title_short Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates
title_full Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates
title_fullStr Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates
title_full_unstemmed Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates
title_sort Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates
dc.creator.none.fl_str_mv Mosquera Mosquera, Jesús
Sánchez López, Mateo Isidro
Valero, Julián
Mendoza, Javier de
Vázquez Sentís, Marco Eugenio
Mascareñas Cid, José Luis
author Mosquera Mosquera, Jesús
author_facet Mosquera Mosquera, Jesús
Sánchez López, Mateo Isidro
Valero, Julián
Mendoza, Javier de
Vázquez Sentís, Marco Eugenio
Mascareñas Cid, José Luis
author_role author
author2 Sánchez López, Mateo Isidro
Valero, Julián
Mendoza, Javier de
Vázquez Sentís, Marco Eugenio
Mascareñas Cid, José Luis
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Centro de Investigación en Química Biolóxica e Materiais Moleculares
Universidade de Santiago de Compostela. Departamento de Química Orgánica
dc.subject.none.fl_str_mv Materias::Investigación::23 Química::2302 Bioquímica
topic Materias::Investigación::23 Química::2302 Bioquímica
description Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA, the oligoguanidinium unit also endows the conjugate with cell internalization properties
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-02-18
2015
2015-02-18
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/12546
url http://hdl.handle.net/10347/12546
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission http://dx.doi.org/10.13039/501100000780 Seventh Framework Programme 340055
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 SAF2013-41943-R HERRAMIENTAS SINTETICAS EN QUIMICA BIOLOGICA. NUEVAS ESTRATEGIAS MOLECULARES PARA EL TRATAMIENTO Y DIAGNOSTICO DE CANCERES
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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