Sequence-selective DNA binding with cell-permeable oligoguanidinium-peptide conjugates

Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA,...

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Detalles Bibliográficos
Autores: Mosquera Mosquera, Jesús, Sánchez López, Mateo Isidro, Valero, Julián, Mendoza, Javier de, Vázquez Sentís, Marco Eugenio, Mascareñas Cid, José Luis
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/12546
Acceso en línea:http://hdl.handle.net/10347/12546
Access Level:acceso abierto
Palabra clave:Materias::Investigación::23 Química::2302 Bioquímica
Descripción
Sumario:Conjugation of a short peptide fragment from a bZIP protein to an oligoguanidinium tail results in a DNA-binding miniprotein that selectively interacts with composite sequences containing the peptide-binding site next to an A/T-rich tract. In addition to stabilizing the complex with the target DNA, the oligoguanidinium unit also endows the conjugate with cell internalization properties

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