Tuning the properties of penetrating peptides by oxime conjugation
We here describe the application of oxime bond formation between a peptide scaffold and different aldehydes to modify the transporting capabilities of penetrating peptides. We show that bonds such as oximes offer a great synthetic advantage for the modification of the properties of model penetrating...
| Autores: | , , , , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2017 |
| País: | España |
| Recursos: | Universidad de Santiago de Compostela (USC) |
| Repositório: | Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela |
| Idioma: | inglês |
| OAI Identifier: | oai:minerva.usc.gal:10347/15141 |
| Acesso em linha: | http://hdl.handle.net/10347/15141 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Materias::Investigación::23 Química::2302 Bioquímica |
| Resumo: | We here describe the application of oxime bond formation between a peptide scaffold and different aldehydes to modify the transporting capabilities of penetrating peptides. We show that bonds such as oximes offer a great synthetic advantage for the modification of the properties of model penetrating peptides. We believe that this approach will allow the development of improved intracellular delivery vehicles |
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