Ruthenium bipyridyl complexes as photocleavable dimerizers: deactivation of DNA-binding peptides using visible light

We report a photolabile biselectrophilic Ru(II) complex that can be used for homo- or heterodimerization of cysteine-containing peptides. The resulting dimers can be efficiently disassembled by long-wavelength light. As proof-of-concept, we describe the preparation of homo- and heterodimeric bZIP pe...

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Detalles Bibliográficos
Autores: Mosquera Mosquera, Jesús, Sánchez López, Mateo Isidro, Vázquez Sentís, Marco Eugenio, Mascareñas Cid, José Luis
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/11968
Acceso en línea:http://hdl.handle.net/10347/11968
Access Level:acceso abierto
Descripción
Sumario:We report a photolabile biselectrophilic Ru(II) complex that can be used for homo- or heterodimerization of cysteine-containing peptides. The resulting dimers can be efficiently disassembled by long-wavelength light. As proof-of-concept, we describe the preparation of homo- and heterodimeric bZIP peptides whose DNA-binding properties can be turned off using visible light