Temporary Electrostatic Impairment of DNA Recognition: Light‐Driven DNA Binding of Peptide Dimers

Appending negatively charged Glu8 tails to a peptide dimer derived from the GCN4 transcription factor leads to an effective suppression of its DNA binding. The specific DNA recognition can be restored by irradiation with UV light by using a photolabile linker between the acidic tail and the DNA bind...

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Detalles Bibliográficos
Autores: Jiménez Balsa, Adrián, Pazos Chantrero, Elena, Martínez Albardonedo, Borja, Mascareñas Cid, José Luis, Vázquez Sentís, Marco Eugenio
Tipo de recurso: artículo
Fecha de publicación:2012
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/18482
Acceso en línea:http://hdl.handle.net/10347/18482
Access Level:acceso abierto
Descripción
Sumario:Appending negatively charged Glu8 tails to a peptide dimer derived from the GCN4 transcription factor leads to an effective suppression of its DNA binding. The specific DNA recognition can be restored by irradiation with UV light by using a photolabile linker between the acidic tail and the DNA binding peptide

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