Relationship between fluid-attenuated inversion-recovery (FLAIR) signal intensity and inflammatory mediator's levels in the hippocampus of patients with temporal lobe epilepsy and mesial temporal sclerosis

We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels...

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Detalhes bibliográficos
Autores: Varella, Pedro Paulo Vasconcellos [UNIFESP], Santiago, Joselita Ferreira Carvalho [UNIFESP], Carrete Junior, Henrique [UNIFESP], Higa, Elisa Mieko Suemitsu [UNIFESP], Yacubian, Elza Márcia Targas [UNIFESP], Centeno, Ricardo Silva [UNIFESP], Caboclo, Luís Otávio Sales Ferreira [UNIFESP], Castro Neto, Eduardo Ferreira de [UNIFESP], Canzian, Mauro, Amado, Débora [UNIFESP], Cavalheiro, Esper Abrão [UNIFESP], Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:Brasil
Recursos:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/6317
Acesso em linha:http://dx.doi.org/10.1590/S0004-282X2011000100018
http://repositorio.unifesp.br/handle/11600/6317
Access Level:acceso abierto
Palavra-chave:FLAIR hippocampal signal
cytokines
NO
glutamate and hippocampal sclerosis
sinal hipocampal em FLAIR
citocinas
glutamato
esclerose hipocampal
Descrição
Resumo:We investigated a relationship between the FLAIR signal found in mesial temporal sclerosis (MTS) and inflammation. Twenty nine patients were selected through clinical and MRI analysis and submitted to cortico-amygdalo-hippocampectomy to seizure control. Glutamate, TNFα, IL1, nitric oxide (NO) levels and immunostaining against IL1β and CD45 was performed. Control tissues (n=10) were obtained after autopsy of patients without neurological disorders. The glutamate was decreased in the temporal lobe epilepsy (TLE) -MTS group (p<0.001), suggesting increased release of this neurotransmitter. The IL1β and TNFα were increased in the hippocampus (p<0.05) demonstrating an active inflammatory process. A positive linear correlation between FLAIR signal and NO and IL1β levels and a negative linear correlation between FLAIR signal and glutamate concentration was found. Lymphocytes infiltrates were present in hippocampi of TLE patients. These data showed an association between hippocampal signal alteration and increased inflammatory markers in TLE-MTS.

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