Temporal lobe epilepsy with mesial temporal sclerosis: hippocampal neuronal loss as a predictor of surgical outcome

OBJECTIVE: To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis. METHOD: Sixty-six patients with medically refractory TLE with unilater...

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Detalhes bibliográficos
Autores: Jardim, Anaclara Prada [UNIFESP], Neves, Rafael Scarpa da Costa [UNIFESP], Caboclo, Luís Otávio Sales Ferreira [UNIFESP], Lancellotti, Carmen Lucia Penteado, Marinho, Murilo Martinez [UNIFESP], Centeno, Ricardo Silva [UNIFESP], Cavalheiro, Esper Abrão [UNIFESP], Scorza, Carla Alessandra [UNIFESP], Yacubian, Elza Márcia Targas [UNIFESP]
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Brasil
Recursos:Universidade Federal de São Paulo (UNIFESP)
Repositorio:Repositório Institucional da UNIFESP
Idioma:inglés
OAI Identifier:oai:repositorio.unifesp.br:11600/7091
Acesso em linha:http://dx.doi.org/10.1590/S0004-282X2012000500003
http://repositorio.unifesp.br/handle/11600/7091
Access Level:acceso abierto
Palavra-chave:epilepsy
temporal lobe
mesial temporal sclerosis
hippocampal sclerosis
pathology
surgical prognosis
epilepsia do lobo temporal
esclerose mesial temporal
esclerose hipocampal
patologia
prognóstico cirúrgico
Descrição
Resumo:OBJECTIVE: To analyze retrospectively a series of patients with temporal lobe epilepsy (TLE) and mesial temporal sclerosis (MTS), and the association of patterns of hippocampal sclerosis with clinical data and surgical prognosis. METHOD: Sixty-six patients with medically refractory TLE with unilateral MTS after anterior temporal lobectomy were included. Quantitative neuropathological evaluation was performed on NeuN-stained hippocampal sections. Patient's clinical data and surgical outcome were reviewed. RESULTS: Occurrence of initial precipitating insult (IPI), as well as better postoperative seizure control (i.e. Engel class 1), were associated with classical and severe patterns of hippocampal sclerosis (MTS type 1a and 1b, respectively). CONCLUSION: Quantitative evaluation of hippocampal neuronal loss patterns predicts surgical outcome in patients with TLE-MTS.

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