Molecular diversity by olefin cross-metathesis on solid support. Generation of libraries of biologically promising β-lactam derivatives
The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary libr...
| Autores: | , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | Argentina |
| Recursos: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/87280 |
| Acesso em linha: | http://hdl.handle.net/11336/87280 |
| Access Level: | acceso abierto |
| Palavra-chave: | CHOLESTEROL ABSORPTION INHIBITORS DIVERSITY ORIENTED SYNTHESIS OLEFIN METATHESIS SOLID-PHASE ORGANIC SYNTHESIS Β-LACTAM DERIVATIVES https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
| Resumo: | The application of the reagent-based diversification strategy for generation of libraries of biologically promising β-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary library, diversity was expanded by applying different cleavage conditions, leading to a series of cholesterol absorption inhibitor analogues together with interesting hybrid compounds through incorporation of a chalcone moiety. |
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