VDR rs2228570 Polymorphism Is Related to Non-Progression to AIDS in Antiretroviral Therapy Naive HIV-Infected Patients

Background: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in a...

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Autores: Jimenez-Sousa, MA, Jimenez, JL, Fernandez-Rodriguez, A, Brochado-Kith, O, Bellon, JM, Bernal-Morell, E, Munoz-Fernandez, MA, Resino, S, del Amo, J, Navarro, ML, Gonzalez, MI, Blanco, JL, Gonzalez, J, Del Amo, J, Jarrin, I, Alejos, B, Hernando, V, Moreno, C, Iniesta, C, Sousa, LMG, Perez, NS, Garcia-Merino, IM, Fernandez, IC, Rico, CG, de la Fuente, JG, Concejo, PP, Portilla, J, Merino, E, Reus, S, Boix, V, Giner, L, Gadea, C, Portilla, I, Pampliega, M, Diez, M, Rodriguez, JC, Sanchez-Paya, J, Gomez, JL, Hernandez, J, Aleman, MR, Alonso, MD, Hernandez, MI, Diaz-Flores, F, Garcia, D, Pelazas, R, Lirola, AL, Rubio, R, Pulido, F, Bisbal, O, Hernando, A, Dominguez, L, Crestelo, DR, Bermejo, L, Santacreu, M, Iribarren, JA, Arrizabalaga, J, Aramburu, MJ, Camino, X, Rodriguez-Arrondo, F, von Wichmann, MA, Tome, LP, Goenaga, MA, Bustinduy, MJ, Azkune, H, Ibarguren, M, Lizardi, A, Kortajarena, X, Gutierrez, F, Masia, M, Padilla, S, Navarro, A, Montolio, F, Robledano, C, Colome, JG, Adsuar, A, Pascual, R, Fernandez, M, Garcia, E, Garcia, JA, Barber, X, Berenguer, J, de Quiros, JCLB, Gutierrez, I, Ramirez, M, Padilla, B, Gijon, P, Aldamiz-Echevarria, T, Tejerina, F, Parras, FJ, Balsalobre, P, Diez, C, Latorre, LP, Vidal, F, Peraire, J, Vilades, C, Veloso, S, Vargas, M, Lopez-Dupla, M, Olona, M, Rull, A, Rodriguez-Gallego, E, Alba, V, Alonso, MM, Aldeguer, JL, Julia, MB, Pitarch, MT, Hernandez, IC, Munoz, EC, Tovar, SC, Lleti, MS, Navarro, JF, Gonzalez-garcia, J, Arnalich, F, Arribas, JR, de la Serna, JIB, Castro, JM, Escosa, L, Herranz, P, Hontanon, V, Garcia-Bujalance, S, Lopez-Hortelano, MG, Gonzalez-Baeza, A, Martin-Carbonero, ML, Mayoral, M, Mellado, MJ, Mican, RE, Montejano, R, Montes, ML, Moreno, V, Perez-Valero, I, Rodes, B, Sainz, T, Sendagorta, E, Alcariz, NS, Valencia, E, Blanco, JR, Oteo, JA, Ibarra, V, Metola, L, Sanz, M, Perez-Martinez, L, Dalmau, D, Jaen, A, Sanmarti, M, Cairo, M, Martinez-Lacasa, J, Velli, P, Font, R, Xercavins, M, Alonso, N, Rivero, M, Reparaz, J, de Alda, MGR, Cano, MTD, de Galarreta, BPR, Segura, F, Amengual, MJ, Navarro, G, Sala, M, Cervantes, M, Pineda, V, Calzado, S, Navarro, M, de los Santos, I, Sanz, JS, Aparicio, AS, Cepeda, CS, Fraile, LGF, Gayo, EM, Moreno, S, Casado, JL, Dronda, F, Moreno, A, Elias, MJP, Ayerbe, CG, Gutierrez, C, Madrid, N, Terron, SD, Marti, P, Ansa, U, Serrano, S, Vivancos, MJ, Bernal, E, Cano, A, Garcia, AA, Urbieta, JB, Munoz, A, Alcaraz, MJ, Villalba, MD, Garcia, F, Pena, A, Munoz, L, Casas, P, Alvarez, M, Chueca, N, Vinuesa, D, Martinez-Montes, C, Del Romero, J, Rodriguez, C, Puerta, T, Carrio, JC, Vera, M, Ballesteros, J, Ayerdi, O, Riera, M, Penaranda, M, Leyes, M, Ribas, MA, Campins, AA, Vidal, C, Fanjul, F, Murillas, J, Homar, F, Santos, J, Viciana, I, Palacios, R, Gonzalez, CM, Viciana, P, Espinosa, N, Lopez-Cortes, LF, Podzamczer, D, Ferrer, E, Imaz, A, Tiraboschi, J, Silva, A, Saumoy, M, Olalla, J, del Arco, A, de la Torre, J, Prada, JL, Guerrero, JMGD, Stachowski, JP, Martinez, OJ, Vera, FJ, Martinez, L, Garcia, J, Alcaraz, B, Jimeno, A, Iglesias, AC, Souto, BP, de Cea, AM, Galera, C, Albendin, H, Perez, A, Iborra, A, Merlos, MA, Vidal, A, Suarez-Garcia, I, Malmierca, E, Gonzalez-Ruano, P, Rodrigo, DM, Mohamed-Balghata, MO, Vidal, MAG, Perez, VE, Molina, MJT, Garcia, JV, Moreno, JPS, Gorgolas, M, Cabello, A, Alvarez, B, Prieto, L, Moreno, JS, Caso, AA, Gutierrez, CH, Mena, MN, Puerto, MJG, Vilalta, RF, Ribera, AF, Roman, AR, Herrero, MTB, Juarez, AR, Lopez, PL, Sanchez, IM, Martinez, JP, Jimenez, MC, Perea, RT, Ruiz-Capillas, JJJ, Pineda, JA
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositório:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p3031
Acesso em linha:https://i3pt.portalinvestigacion.com/publicaciones/3031
Access Level:Acceso aberto
Palavra-chave:single nucleotide polymorphisms
VDR
LTNPs
AIDS
non-progression
Descrição
Resumo:Background: Vitamin D is a fundamental regulator of host defenses by activating genes related to innate and adaptive immunity. In this study, we analyzed the association among single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene, with clinical patterns of AIDS progression in antiretroviral treatment (ART)-naive HIV-infected patients. Methods: We conducted a retrospective study in 667 HIV-infected patients, who were classified within three groups according to their AIDS progression pattern (183 long-term non-progressors (LTNPs), 334 moderate progressors (MPs), and 150 rapid progressors (RPs)). Five VDR SNPs (rs11568820, rs4516035, rs2228570, rs1544410, and rs7975232) were genotyped using Agena Bioscience's MassARRAY platform. Results: Significant association results were found for rs2228570. Within all HIV patients, the presence of T allele at VDR rs2228570 SNP was protective against AIDS progression (ordinal outcome) under additive (adjusted odds ratio (aOR) = 0.75; p = 0.009), dominant (aOR = 0.69; p = 0.015), and codominant (aOR = 0.56; p = 0.017) inheritance models. In addition, the same allele was protective under additive and codominant inheritance models when we compared with LTNPs vs. RPs [aOR = 0.64 (p = 0.019) and aOR = 0.37 (p = 0.018), respectively] and when we compared MPs vs. RPs [aOR = 0.72 (p = 0.035) and aOR = 0.45 (p = 0.028), respectively]. Conclusions: The VDR rs2228570 T allele was related to a lower AIDS progression pattern in ART-naive HIV-infected patients. These findings expand upon the knowledge about HIV pathogenesis in untreated HIV-infected patients with different clinical outcomes.

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