Beneficial effect of bilingualism on Alzheimer's disease CSF biomarkers and cognition

Bilingualism as a component of cognitive reserve has been claimed to delay the onset of Alzheimer’s disease (AD). However, its effect on cerebrospinal fluid (CSF) AD-biomarkers has not been investigated. We assessed cognitive performance and CSF AD-biomarkers, and potential moderation effect of bili...

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Autores: Estanga Alustiza, Ainara, Ecay Torres, Mirian, Ibáñez, Almudena, Izagirre Otaegi, Andrea, Villanua Bernues, Jorge Alberto, García Sebastián, Maite, Iglesias Gaspar, María Teresa, Otaegui Arrazola, Ane, Iriondo Juaristi, Ane, Clerigué, Montserrat, Martínez-Lage Alvarez, Pablo
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/72301
Acceso en línea:http://hdl.handle.net/10810/72301
Access Level:acceso abierto
Palabra clave:bilingualism
preclinical Alzheimer’s disease
CSF biomarkers
cognitive performance
cognitive/brain reserve
cohort studies
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spelling Beneficial effect of bilingualism on Alzheimer's disease CSF biomarkers and cognitionEstanga Alustiza, AinaraEcay Torres, MirianIbáñez, AlmudenaIzagirre Otaegi, AndreaVillanua Bernues, Jorge AlbertoGarcía Sebastián, MaiteIglesias Gaspar, María TeresaOtaegui Arrazola, AneIriondo Juaristi, AneClerigué, MontserratMartínez-Lage Alvarez, Pablobilingualismpreclinical Alzheimer’s diseaseCSF biomarkerscognitive performancecognitive/brain reservecohort studiesBilingualism as a component of cognitive reserve has been claimed to delay the onset of Alzheimer’s disease (AD). However, its effect on cerebrospinal fluid (CSF) AD-biomarkers has not been investigated. We assessed cognitive performance and CSF AD-biomarkers, and potential moderation effect of bilingualism on the association between age, CSF AD-biomarkers, and cognition. Cognitively healthy middle-aged participants classified as monolinguals (n ¼ 100, nCSF ¼ 59), early (n ¼ 81, n CSF ¼ 55) and late bilinguals (n ¼ 97, nCSF ¼ 52) were evaluated. Models adjusted for confounders showed that bi- linguals performed better than monolinguals on digits backwards (early-bilinguals p ¼ 0.003), Judgment of Line Orientation (JLO) (early-bilinguals p ¼ 0.018; late-bilinguals p ¼ 0.004), and Trail Making Test-B (late-bilinguals p ¼ 0.047). Early bilingualism was associated with lower CSF total-tau (p ¼ 0.019) and lower prevalence of preclinical AD (NIA-AA classification) (p ¼ 0.02). Bilingualism showed a moderation effect on the relationship between age and CSF AD-biomarkers and the relationship between age and executive function. We conclude that bilingualism contributes to cognitive reserve enhancing executive and visual-spatial functions. For the first time, this study reveals that early bilingualism is associated with more favorable CSF AD-biomarker profile.The GAP study was supported by Fundación CITA-alzhéimer Fundazioa; the Ministry of Health of Spain (grant numbers PI12/02262 and PI1500919); and the Basque Country Government (grant numbers S-PR12CH001 and S-PR13ZH001).Elsevier202520252016info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/72301reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://doi.org/10.1016/j.neurobiolaging.2016.10.013info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/© 2016 Elsevier under CC BY-NC-ND licenseoai:addi.ehu.eus:10810/723012026-06-18T09:23:17Z
dc.title.none.fl_str_mv Beneficial effect of bilingualism on Alzheimer's disease CSF biomarkers and cognition
title Beneficial effect of bilingualism on Alzheimer's disease CSF biomarkers and cognition
spellingShingle Beneficial effect of bilingualism on Alzheimer's disease CSF biomarkers and cognition
Estanga Alustiza, Ainara
bilingualism
preclinical Alzheimer’s disease
CSF biomarkers
cognitive performance
cognitive/brain reserve
cohort studies
title_short Beneficial effect of bilingualism on Alzheimer's disease CSF biomarkers and cognition
title_full Beneficial effect of bilingualism on Alzheimer's disease CSF biomarkers and cognition
title_fullStr Beneficial effect of bilingualism on Alzheimer's disease CSF biomarkers and cognition
title_full_unstemmed Beneficial effect of bilingualism on Alzheimer's disease CSF biomarkers and cognition
title_sort Beneficial effect of bilingualism on Alzheimer's disease CSF biomarkers and cognition
dc.creator.none.fl_str_mv Estanga Alustiza, Ainara
Ecay Torres, Mirian
Ibáñez, Almudena
Izagirre Otaegi, Andrea
Villanua Bernues, Jorge Alberto
García Sebastián, Maite
Iglesias Gaspar, María Teresa
Otaegui Arrazola, Ane
Iriondo Juaristi, Ane
Clerigué, Montserrat
Martínez-Lage Alvarez, Pablo
author Estanga Alustiza, Ainara
author_facet Estanga Alustiza, Ainara
Ecay Torres, Mirian
Ibáñez, Almudena
Izagirre Otaegi, Andrea
Villanua Bernues, Jorge Alberto
García Sebastián, Maite
Iglesias Gaspar, María Teresa
Otaegui Arrazola, Ane
Iriondo Juaristi, Ane
Clerigué, Montserrat
Martínez-Lage Alvarez, Pablo
author_role author
author2 Ecay Torres, Mirian
Ibáñez, Almudena
Izagirre Otaegi, Andrea
Villanua Bernues, Jorge Alberto
García Sebastián, Maite
Iglesias Gaspar, María Teresa
Otaegui Arrazola, Ane
Iriondo Juaristi, Ane
Clerigué, Montserrat
Martínez-Lage Alvarez, Pablo
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv bilingualism
preclinical Alzheimer’s disease
CSF biomarkers
cognitive performance
cognitive/brain reserve
cohort studies
topic bilingualism
preclinical Alzheimer’s disease
CSF biomarkers
cognitive performance
cognitive/brain reserve
cohort studies
description Bilingualism as a component of cognitive reserve has been claimed to delay the onset of Alzheimer’s disease (AD). However, its effect on cerebrospinal fluid (CSF) AD-biomarkers has not been investigated. We assessed cognitive performance and CSF AD-biomarkers, and potential moderation effect of bilingualism on the association between age, CSF AD-biomarkers, and cognition. Cognitively healthy middle-aged participants classified as monolinguals (n ¼ 100, nCSF ¼ 59), early (n ¼ 81, n CSF ¼ 55) and late bilinguals (n ¼ 97, nCSF ¼ 52) were evaluated. Models adjusted for confounders showed that bi- linguals performed better than monolinguals on digits backwards (early-bilinguals p ¼ 0.003), Judgment of Line Orientation (JLO) (early-bilinguals p ¼ 0.018; late-bilinguals p ¼ 0.004), and Trail Making Test-B (late-bilinguals p ¼ 0.047). Early bilingualism was associated with lower CSF total-tau (p ¼ 0.019) and lower prevalence of preclinical AD (NIA-AA classification) (p ¼ 0.02). Bilingualism showed a moderation effect on the relationship between age and CSF AD-biomarkers and the relationship between age and executive function. We conclude that bilingualism contributes to cognitive reserve enhancing executive and visual-spatial functions. For the first time, this study reveals that early bilingualism is associated with more favorable CSF AD-biomarker profile.
publishDate 2016
dc.date.none.fl_str_mv 2016
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/72301
url http://hdl.handle.net/10810/72301
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.neurobiolaging.2016.10.013
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
© 2016 Elsevier under CC BY-NC-ND license
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
© 2016 Elsevier under CC BY-NC-ND license
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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