Intestinal epithelial cell response to Endoplasmic Reticulum stress in Inflammatory Bowel Disease

Inflammatory Bowel Disease (IBD), including Crohn's disease (CD) and Ulcerative colitis (UC), is characterized by a chronic relapsing intestinal inflammation. Although its etiology remains unknown, it involves complex interactions between the immune response and genetic, environmental or microb...

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Detalles Bibliográficos
Autor: Martín Adrados, Beatriz
Tipo de recurso: tesis doctoral
Fecha de publicación:2023
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/91003
Acceso en línea:https://hdl.handle.net/20.500.14352/91003
Access Level:acceso abierto
Palabra clave:616.34(043.2)
Intestines
Intestinos
Medicina interna
3205 Medicina Interna
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spelling Intestinal epithelial cell response to Endoplasmic Reticulum stress in Inflammatory Bowel DiseaseRespuesta de las células epiteliales intestinales al estrés del Retículo Endoplásmico en la Enfermedad Inflamatoria IntestinalMartín Adrados, Beatriz616.34(043.2)IntestinesIntestinosMedicina interna3205 Medicina InternaInflammatory Bowel Disease (IBD), including Crohn's disease (CD) and Ulcerative colitis (UC), is characterized by a chronic relapsing intestinal inflammation. Although its etiology remains unknown, it involves complex interactions between the immune response and genetic, environmental or microbial factors such as Short-Chain Fatty Acids (SCFAs) which are implicated in intestinal epithelial cell (IEC) homeostasis as well as in the regulation of the gut immune system. In turn, IECs are critical for maintaining the intestinal barrier and can secrete and respond to various mediators that regulate the immune response in the gut.The Unfolded Protein Response (UPR) is a mechanism triggered by the accumulation of unfolded or misfolded proteins within the ER lumen, a condition known as Endoplasmic Reticulum (ER) stress. The UPR plays a critical role in maintaining the homeostasis of the intestinal epithelium by keeping the balance between the microbiota, IECs and the immune response. Moreover, a dysfunctional UPR may be linked to several inflammatory diseases including IBD, although the underlying mechanisms are largely unknown.The aim of the present work was to identify Unfolded Protein Response-related mechanisms that might be involved in the triggering or the perpetuation of the inflammatory response in Inflammatory Bowel Disease...Universidad Complutense de MadridMartínez Naves, EduardoGómez Del Moral Martín-Consuegra, Manuel MaríaUniversidad Complutense de Madrid20232023-11-3020232023-11-30doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/91003reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/910032026-06-02T12:44:21Z
dc.title.none.fl_str_mv Intestinal epithelial cell response to Endoplasmic Reticulum stress in Inflammatory Bowel Disease
Respuesta de las células epiteliales intestinales al estrés del Retículo Endoplásmico en la Enfermedad Inflamatoria Intestinal
title Intestinal epithelial cell response to Endoplasmic Reticulum stress in Inflammatory Bowel Disease
spellingShingle Intestinal epithelial cell response to Endoplasmic Reticulum stress in Inflammatory Bowel Disease
Martín Adrados, Beatriz
616.34(043.2)
Intestines
Intestinos
Medicina interna
3205 Medicina Interna
title_short Intestinal epithelial cell response to Endoplasmic Reticulum stress in Inflammatory Bowel Disease
title_full Intestinal epithelial cell response to Endoplasmic Reticulum stress in Inflammatory Bowel Disease
title_fullStr Intestinal epithelial cell response to Endoplasmic Reticulum stress in Inflammatory Bowel Disease
title_full_unstemmed Intestinal epithelial cell response to Endoplasmic Reticulum stress in Inflammatory Bowel Disease
title_sort Intestinal epithelial cell response to Endoplasmic Reticulum stress in Inflammatory Bowel Disease
dc.creator.none.fl_str_mv Martín Adrados, Beatriz
author Martín Adrados, Beatriz
author_facet Martín Adrados, Beatriz
author_role author
dc.contributor.none.fl_str_mv Martínez Naves, Eduardo
Gómez Del Moral Martín-Consuegra, Manuel María
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.34(043.2)
Intestines
Intestinos
Medicina interna
3205 Medicina Interna
topic 616.34(043.2)
Intestines
Intestinos
Medicina interna
3205 Medicina Interna
description Inflammatory Bowel Disease (IBD), including Crohn's disease (CD) and Ulcerative colitis (UC), is characterized by a chronic relapsing intestinal inflammation. Although its etiology remains unknown, it involves complex interactions between the immune response and genetic, environmental or microbial factors such as Short-Chain Fatty Acids (SCFAs) which are implicated in intestinal epithelial cell (IEC) homeostasis as well as in the regulation of the gut immune system. In turn, IECs are critical for maintaining the intestinal barrier and can secrete and respond to various mediators that regulate the immune response in the gut.The Unfolded Protein Response (UPR) is a mechanism triggered by the accumulation of unfolded or misfolded proteins within the ER lumen, a condition known as Endoplasmic Reticulum (ER) stress. The UPR plays a critical role in maintaining the homeostasis of the intestinal epithelium by keeping the balance between the microbiota, IECs and the immune response. Moreover, a dysfunctional UPR may be linked to several inflammatory diseases including IBD, although the underlying mechanisms are largely unknown.The aim of the present work was to identify Unfolded Protein Response-related mechanisms that might be involved in the triggering or the perpetuation of the inflammatory response in Inflammatory Bowel Disease...
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-11-30
2023
2023-11-30
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/91003
url https://hdl.handle.net/20.500.14352/91003
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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