Microbial transformation of the diterpene 7-epi-foliol by Fusarium fujikuroi
The incubation of 3,7,18-trihydroxy-ent-kaur-16-ene (7-epi-foliol) with the fungus Fusarium fujikuroi gave 3,7,18-trihydroxy-ent-kaur-16-en-18-al as the sole product. The biotransformation of other 7- or 7-hydroxy derivatives had led to the oxidation of C-19, which is a main step in the biosyn...
| Autores: | , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | España |
| Recursos: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/180336 |
| Acesso em linha: | http://hdl.handle.net/10261/180336 |
| Access Level: | acceso abierto |
| Palavra-chave: | Diterpenes 7-epi-Foliol 18-Oxo-7-epi-foliol Ent-Kaur-16-enes Fusarium fujikuroi Biotransformations |
| Resumo: | The incubation of 3,7,18-trihydroxy-ent-kaur-16-ene (7-epi-foliol) with the fungus Fusarium fujikuroi gave 3,7,18-trihydroxy-ent-kaur-16-en-18-al as the sole product. The biotransformation of other 7- or 7-hydroxy derivatives had led to the oxidation of C-19, which is a main step in the biosynthesis of gibberellins and kaurenolides. Now, the presence of the 3-hydroxyl impedes that oxidation, which is directed to the adjacent C-18 hydroxymethyl forming the corresponding aldehyde. |
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