Dietary vitamin D intake and 2-year changes in cognitive function in older adults with overweight or obesity and metabolic syndrome

The protective role of dietary vitamin D intake on cognitive function is of interest, but evidence remains inconsistent. We aimed to evaluate the association between dietary vitamin D intake and 2-year cognitive changes in older adults at risk of cognitive decline. This longitudinal study comprised...

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Detalhes bibliográficos
Autores: Vázquez-Lorente, H, Ni, JQ, Paz-Graniel, I, Toledo, E, Corella, D, Castañer, O, Martínez, JA, Alonso-Gómez, AM, Wärnberg, J, Vioque, J, Romaguera, D, López-Miranda, J, Estruch, R, Tinahones, FJ, Lapetra, J, Serra-Majem, L, Bouzalmate-Hajjaj, A, Tur, JA, Pérez, RMM, Fanlo, M, Delgado-Rodríguez, M, Bustelo, AB, Vidal, J, Vázquez, C, Daimiel, L, Ros, E, Fernández-Aranda, F, Rognoni, T, Babio, N, Asensio, EM, Pérez-Vega, KA, Garcia-Rios, A, Compañ-Gabucio, L, Cueto-Galán, R, Zulet, MA, Nafria, M, Casas, R, Cano-Ibáñez, N, Tojal-Sierra, L, Gómez-Pérez, AM, Goñi, N, Sorli, JV, Zomeño, MD, Arenas-Larriva, AP, Jiménez-Sellés, P, Basterra-Gortari, J, Fitó, M, Salas-Salvadó, J
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:dnet:isabial_____::cd91b773b856e86f9dd262d4c57767f2
Acesso em linha:https://isabial.portalinvestigacion.com/publicaciones12530
https://link.springer.com/article/10.1007/s11357-025-01670-1?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate
Access Level:acceso abierto
Palavra-chave:Vitamin D
Cognition
Cognitive decline
Cognitive function
Aging
Older people
Descrição
Resumo:The protective role of dietary vitamin D intake on cognitive function is of interest, but evidence remains inconsistent. We aimed to evaluate the association between dietary vitamin D intake and 2-year cognitive changes in older adults at risk of cognitive decline. This longitudinal study comprised 5454 individuals (aged 55-75 years in men and 60-75 years in women) who exhibited overweight/obesity and metabolic syndrome. Data on dietary vitamin D intake was assessed using a validated 143-item food frequency questionnaire. Cognitive function was assessed through five composite scores derived from a comprehensive battery of eight neuropsychological tests, encompassing global cognitive function, general cognitive function, attention, executive function, and language domains. Multivariable-adjusted linear regression models were fitted to examine the association between energy-adjusted cumulative average dietary vitamin D intake over time and 2-year changes in cognitive function. After adjusting for multiple covariates, energy-adjusted cumulative average dietary vitamin D intake as a continuous variable was associated with greater 2-year improvements in global cognitive function (beta 1.18 x 10-2; 95% CI 0.19 x 10-2 to 2.17 x 10-2), executive function (beta 1.12 x 10-2; 95% CI 0.03 x 10-2 to 2.21 x 10-2), and language (beta 1.61 x 10-2; 95% CI 0.43 x 10-2 to 2.78 x 10-2). Additionally, the higher cumulative average dietary vitamin D intake quartile was associated with an increase in global cognitive function (beta 7.10 x 10-2; 95% CI 0.59 x 10-2 to 13.6 x 10-2), language (beta 7.07 x 10-2; 95% CI - 0.52 x 10-2 to 14.7 x 10-2), and a lower decline in attention (beta 9.58 x 10-2; 95% CI 1.60 x 10-2 to 17.5 x 10-2). A higher dietary vitamin D intake was associated with modest favorable changes in cognitive function and a reduced cognitive decline over a 2-year period. These findings highlight the need for further research to explore the potential benefits of boosting dietary vitamin D intake for cognitive health in older adults.

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