Dietary vitamin D intake and 2-year changes in cognitive function in older adults with overweight or obesity and metabolic syndrome

The protective role of dietary vitamin D intake on cognitive function is of interest, but evidence remains inconsistent. We aimed to evaluate the association between dietary vitamin D intake and 2-year cognitive changes in older adults at risk of cognitive decline. This longitudinal study comprised...

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Detalhes bibliográficos
Autores: Vázquez-Lorente, Héctor, Ni, Jiaqi, Paz-Graniel, Indira, Toledo, Estefanía, Corella, Dolores, Castañer, Olga, Martínez, J Alfredo, Alonso-Gómez, Ángel M, Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J, Lapetra, José, Serra-Majem, Lluís, Bouzalmate-Hajjaj, Amira, Tur, Josep A, Pérez, Rafael M Micó, Fanlo, Marta, Delgado-Rodríguez, Miguel, Bustelo, Ana Barabash, Vidal, Josep, Vázquez, Clotilde, Daimiel, Lidia, Ros, Emili, Fernández-Aranda, Fernando, Rognoni, Teresa, Babio, Nancy, Asensio, Eva M, Pérez-Vega, Karla-Alejandra, Garcia-Rios, Antonio, Compañ-Gabucio, Laura, Cueto-Galán, Raquel, Zulet, M Angeles, Nafría, Mar, Casas, Rosa, Cano-Ibáñez, Naomi, Tojal-Sierra, Luis, Gómez-Pérez, Ana María, Goñi, Nuria, Sorli, José V, Zomeño, María Dolores, Arenas-Larriva, Antonio P, Jiménez-Sellés, Pedro, Basterra-Gortari, Javier, Fitó, Montserrat, Salas-Salvadó, Jordi
Formato: artículo
Fecha de publicación:2025
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/25051
Acesso em linha:https://hdl.handle.net/20.500.13003/25051
Access Level:acceso abierto
Palavra-chave:Aging
Cognition
Cognitive decline
Cognitive function
Older people
Vitamin D
Descrição
Resumo:The protective role of dietary vitamin D intake on cognitive function is of interest, but evidence remains inconsistent. We aimed to evaluate the association between dietary vitamin D intake and 2-year cognitive changes in older adults at risk of cognitive decline. This longitudinal study comprised 5454 individuals (aged 55-75 years in men and 60-75 years in women) who exhibited overweight/obesity and metabolic syndrome. Data on dietary vitamin D intake was assessed using a validated 143-item food frequency questionnaire. Cognitive function was assessed through five composite scores derived from a comprehensive battery of eight neuropsychological tests, encompassing global cognitive function, general cognitive function, attention, executive function, and language domains. Multivariable-adjusted linear regression models were fitted to examine the association between energy-adjusted cumulative average dietary vitamin D intake over time and 2-year changes in cognitive function. After adjusting for multiple covariates, energy-adjusted cumulative average dietary vitamin D intake as a continuous variable was associated with greater 2-year improvements in global cognitive function (β 1.18 × 10-2; 95% CI 0.19 × 10-2 to 2.17 × 10-2), executive function (β 1.12 × 10-2; 95% CI 0.03 × 10-2 to 2.21 × 10-2), and language (β 1.61 × 10-2; 95% CI 0.43 × 10-2 to 2.78 × 10-2). Additionally, the higher cumulative average dietary vitamin D intake quartile was associated with an increase in global cognitive function (β 7.10 × 10-2; 95% CI 0.59 × 10-2 to 13.6 × 10-2), language (β 7.07 × 10-2; 95% CI - 0.52 × 10-2 to 14.7 × 10-2), and a lower decline in attention (β 9.58 × 10-2; 95% CI 1.60 × 10-2 to 17.5 × 10-2). A higher dietary vitamin D intake was associated with modest favorable changes in cognitive function and a reduced cognitive decline over a 2-year period. These findings highlight the need for further research to explore the potential benefits of boosting dietary vitamin D intake for cognitive health in older adults.

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