Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C−C Bond Scission

Herein, we describe the development of a copper-catalyzed C(sp3)-amination of proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the intermediacy of open-shell species arising from homolytic C−C bond-cleavage driven by aromatization. The protocol is characterized by i...

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Detalles Bibliográficos
Autores: Xin-Yang, Lv, Roman, Abrams, Martin, Ruben
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2072/535770
Acceso en línea:http://hdl.handle.net/2072/535770
https://doi.org/10.1002/anie.202217386
Access Level:acceso abierto
Palabra clave:Quimica
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spelling Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C−C Bond ScissionXin-Yang, LvRoman, AbramsMartin, RubenQuimica00Herein, we describe the development of a copper-catalyzed C(sp3)-amination of proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the intermediacy of open-shell species arising from homolytic C−C bond-cleavage driven by aromatization. The protocol is characterized by its operational simplicity and generality, including chemical diversification of advanced intermediates.Wiley-VCH2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6 p.application/pdfhttp://hdl.handle.net/2072/535770https://doi.org/10.1002/anie.202217386RECERCAT (Dipòsit de la Recerca de Catalunya)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFEDER/MCI PID2021-123801NB-I00China Scholarship Council (CSC)European Research Council (ERC) under European Union's Horizon 2020 research and innovation program (grant agreement No 883756)Creative Commons. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)info:eu-repo/semantics/openAccessoai:recercat.cat:2072/5357702026-05-29T05:05:01Z
dc.title.none.fl_str_mv Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C−C Bond Scission
title Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C−C Bond Scission
spellingShingle Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C−C Bond Scission
Xin-Yang, Lv
Quimica
00
title_short Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C−C Bond Scission
title_full Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C−C Bond Scission
title_fullStr Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C−C Bond Scission
title_full_unstemmed Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C−C Bond Scission
title_sort Copper-Catalyzed C(sp3)-Amination of Ketone-Derived Dihydroquinazolinones by Aromatization-Driven C−C Bond Scission
dc.creator.none.fl_str_mv Xin-Yang, Lv
Roman, Abrams
Martin, Ruben
author Xin-Yang, Lv
author_facet Xin-Yang, Lv
Roman, Abrams
Martin, Ruben
author_role author
author2 Roman, Abrams
Martin, Ruben
author2_role author
author
dc.subject.none.fl_str_mv Quimica
00
topic Quimica
00
description Herein, we describe the development of a copper-catalyzed C(sp3)-amination of proaromatic dihydroquinazolinones derived from ketones. The reaction is enabled by the intermediacy of open-shell species arising from homolytic C−C bond-cleavage driven by aromatization. The protocol is characterized by its operational simplicity and generality, including chemical diversification of advanced intermediates.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/2072/535770
https://doi.org/10.1002/anie.202217386
url http://hdl.handle.net/2072/535770
https://doi.org/10.1002/anie.202217386
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv FEDER/MCI PID2021-123801NB-I00
China Scholarship Council (CSC)
European Research Council (ERC) under European Union's Horizon 2020 research and innovation program (grant agreement No 883756)
dc.rights.none.fl_str_mv Creative Commons. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Creative Commons. Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 6 p.
application/pdf
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv RECERCAT (Dipòsit de la Recerca de Catalunya)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.228081

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