Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis

Barral, Aldina Maria Prado. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.

Detalles Bibliográficos
Autores: Carvalho, Edgar Marcelino de, Barral, Aldina Maria Prado, Costa, Jackson Mauricio Lopes, Bittencourt, Achilea Candida Lisboa, Marsden, Philip
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1994
País:Brasil
Institución:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/22838
Acceso en línea:https://arca.fiocruz.br/handle/icict/22838
Access Level:acceso abierto
Palabra clave:Leishmaniose
Leishmaniose cutânea
Leishmaniose cutânea disseminada
Leishmaniose tegumentar
Imunologia em leishmaniose
Leishmaniasis
Cutaneous leishmaniasis
Disseminated cutaneous leishmaniasis
Tegumentary leishmaniasis
Immunology in leishmaniasis
id BR_ef2699c8159b1f0b7c702745be89906f
oai_identifier_str oai:arca.fiocruz.br:icict/22838
network_acronym_str BR
network_name_str Brasil
repository_id_str
dc.title.none.fl_str_mv Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
title Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
spellingShingle Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
Carvalho, Edgar Marcelino de
Leishmaniose
Leishmaniose cutânea
Leishmaniose cutânea disseminada
Leishmaniose tegumentar
Imunologia em leishmaniose
Leishmaniasis
Cutaneous leishmaniasis
Disseminated cutaneous leishmaniasis
Tegumentary leishmaniasis
Immunology in leishmaniasis
title_short Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
title_full Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
title_fullStr Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
title_full_unstemmed Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
title_sort Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
dc.creator.none.fl_str_mv Carvalho, Edgar Marcelino de
Barral, Aldina Maria Prado
Costa, Jackson Mauricio Lopes
Bittencourt, Achilea Candida Lisboa
Marsden, Philip
author Carvalho, Edgar Marcelino de
author_facet Carvalho, Edgar Marcelino de
Barral, Aldina Maria Prado
Costa, Jackson Mauricio Lopes
Bittencourt, Achilea Candida Lisboa
Marsden, Philip
author_role author
author2 Barral, Aldina Maria Prado
Costa, Jackson Mauricio Lopes
Bittencourt, Achilea Candida Lisboa
Marsden, Philip
author2_role author
author
author
author
dc.subject.other.none.fl_str_mv Leishmaniose
Leishmaniose cutânea
Leishmaniose cutânea disseminada
Leishmaniose tegumentar
Imunologia em leishmaniose
topic Leishmaniose
Leishmaniose cutânea
Leishmaniose cutânea disseminada
Leishmaniose tegumentar
Imunologia em leishmaniose
Leishmaniasis
Cutaneous leishmaniasis
Disseminated cutaneous leishmaniasis
Tegumentary leishmaniasis
Immunology in leishmaniasis
dc.subject.en.none.fl_str_mv Leishmaniasis
Cutaneous leishmaniasis
Disseminated cutaneous leishmaniasis
Tegumentary leishmaniasis
Immunology in leishmaniasis
description Barral, Aldina Maria Prado. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 1994
dc.date.issued.fl_str_mv 1994
dc.date.accessioned.fl_str_mv 2017-10-17T12:24:38Z
dc.date.available.fl_str_mv 2017-10-17T12:24:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CARVALHO, E. M. et al. Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis. Acta Tropica, v. 56, p. 315-325, 1994.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/22838
dc.identifier.issn.none.fl_str_mv 0001-706X
identifier_str_mv CARVALHO, E. M. et al. Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis. Acta Tropica, v. 56, p. 315-325, 1994.
0001-706X
url https://arca.fiocruz.br/handle/icict/22838
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://arca.fiocruz.br/bitstreams/d2a3e6c7-634e-482d-bdc5-8b62059a8500/download
https://arca.fiocruz.br/bitstreams/241b5137-94d7-4706-ad84-abf2bd9e824e/download
https://arca.fiocruz.br/bitstreams/3a056a62-b100-4d65-a174-61a63b974492/download
https://arca.fiocruz.br/bitstreams/755b6e6f-1e1b-4c96-8b9d-8ef88ae83b7e/download
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
6711d34110b8e9e39bf8f36a3346a72a
041db9d0ea712bc8ee1f6b9261c3ec4f
6d83a6b400decfa6af4b2ca88a1b3700
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1853674280265449472
spelling 2017-10-17T12:24:38Z2017-10-17T12:24:38Z1994CARVALHO, E. M. et al. Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis. Acta Tropica, v. 56, p. 315-325, 1994.0001-706Xhttps://arca.fiocruz.br/handle/icict/22838Barral, Aldina Maria Prado. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Grant AI30639 from the National Institutes of Health and UNDP World Bank/WHO Special Program for Research and Training in Tropical Diseases and CNPq.Hospital Universitdrio Professor Edgard Santos. Departamento de Patologia. Service de Imunologia. Salvador, BA, BrasilHospital Universitdrio Professor Edgard Santos. Departamento de Patologia. Service de Imunologia. Salvador, BA, BrasilUniversidade Federal do Maranhão. São Luís, MA, BrasilHospital Universitdrio Professor Edgard Santos. Departamento de Patologia. Service de Imunologia. Salvador, BA, BrasilUniversidade de Brasilia. Brasília, DF, BrasilThe ciinico-pathological and immunological findings in eight patients from Bahia, Brazil with disseminated cutaneous leishmaniasis are described. This condition differs from anergic diffuse cutaneous leishmaniasis (DCL) and from classical American cutaneous leishmaniasis (ACL). The number of lesions in these patients ranged from 75 to 800 and were characterized by papules and an acneiform type of lesion with a few ulcers rather than nodules that are the main characteristic of DCL. On the other hand the high incidence of mucosal disease (38%) in patients with disseminated cutaneous leishmaniasis make the prevalence of mucosal involvement in this condition higher than that observed in ACL. L. amazonensis (five cases) and L. braziliensis (two cases) were the causal agents in the patients where the infecting agent was characterized. Antibody titers in disseminated cutaneous leishmaniasis were higher than those observed in ACL and patients with the highest antibody titers had mucosal envolvement. Abnormalities in cellular immunity that are not observed in ACL such as decrease in CD4 + cells and absence of T cell response to leishmania antigen were observed in several patients with disseminated cutaneous leishmaniasis but restoration of these abnormalities occurred after treatment. In spite of the great number of lesions, the therapeutic response was good in six patients with disappearance of the lesions in a period shorter than that observed in ACL. In the two patients that presented therapeutic failure the causal agent was L. amazonensis. In such patients there was a predominance of ulcerated lesions, and a high titer of antibody was detectedengElsevierLeishmanioseLeishmaniose cutâneaLeishmaniose cutânea disseminadaLeishmaniose tegumentarImunologia em leishmanioseLeishmaniasisCutaneous leishmaniasisDisseminated cutaneous leishmaniasisTegumentary leishmaniasisImmunology in leishmaniasisClinical and immunopathological aspects of disseminated cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZCarvalho, Edgar Marcelino deBarral, Aldina Maria PradoCosta, Jackson Mauricio LopesBittencourt, Achilea Candida LisboaMarsden, PhilipLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://arca.fiocruz.br/bitstreams/d2a3e6c7-634e-482d-bdc5-8b62059a8500/download5a560609d32a3863062d77ff32785d58MD51falseAnonymousREADORIGINALCarvalho EM Clinical and immunopathological....pdfCarvalho EM Clinical and immunopathological....pdfapplication/pdf852510https://arca.fiocruz.br/bitstreams/241b5137-94d7-4706-ad84-abf2bd9e824e/download6711d34110b8e9e39bf8f36a3346a72aMD52trueAnonymousREADTEXTCarvalho EM Clinical and immunopathological....pdf.txtCarvalho EM Clinical and immunopathological....pdf.txtExtracted texttext/plain27322https://arca.fiocruz.br/bitstreams/3a056a62-b100-4d65-a174-61a63b974492/download041db9d0ea712bc8ee1f6b9261c3ec4fMD57falseAnonymousREADTHUMBNAILCarvalho EM Clinical and immunopathological....pdf.jpgCarvalho EM Clinical and immunopathological....pdf.jpgGenerated Thumbnailimage/jpeg35088https://arca.fiocruz.br/bitstreams/755b6e6f-1e1b-4c96-8b9d-8ef88ae83b7e/download6d83a6b400decfa6af4b2ca88a1b3700MD58falseAnonymousREADicict/228382025-12-10 14:28:20.588open.accessoai:arca.fiocruz.br:icict/22838https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-10T17:28:20Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)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
score 15,301629

Similares en LA Referencia