Estudo histológico e imunoistoquímico do sistema nervoso central de cães naturalmente infectados por Leishmania (Leishmania) chagasi
The present study aimed to characterize the histopathological alterations and to detect, by immunohistochemistry, the presence of amastigote forms of Leishmania in CNS tissue of dogs with and without neurological clinical signs of the disease. Two groups of animals were used: the first was composed...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2007 |
| País: | Brasil |
| Institución: | Universidade Estadual Paulista (UNESP) |
| Repositorio: | Repositório Institucional da UNESP |
| Idioma: | portugués |
| OAI Identifier: | oai:repositorio.unesp.br:11449/70191 |
| Acceso en línea: | http://www.revistas.usp.br/bjvras/article/view/26653 http://hdl.handle.net/11449/70191 |
| Access Level: | acceso abierto |
| Palabra clave: | Central nervous system Dogs Histopathology Immunohistochemistry Leishmania chagasi Animalia Canis familiaris Leishmania donovani chagasi |
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Estudo histológico e imunoistoquímico do sistema nervoso central de cães naturalmente infectados por Leishmania (Leishmania) chagasiHistological and immunohistochemical study of the central nervous system of dogs naturally infected by Leishmania (Leishmania) chagasiCentral nervous systemDogsHistopathologyImmunohistochemistryLeishmania chagasiAnimaliaCanis familiarisLeishmania donovani chagasiThe present study aimed to characterize the histopathological alterations and to detect, by immunohistochemistry, the presence of amastigote forms of Leishmania in CNS tissue of dogs with and without neurological clinical signs of the disease. Two groups of animals were used: the first was composed of 18 dogs with visceral leishmaniasis without clinical evidence of neurological involvement, and the second, composed of 21 dogs with visceral leishmaniasis and neurological symptoms. The most frequent histopathological alterations found in the CNS of dogs of both groups were neuronal degeneration with neuronophagia, gliosis, leptomeningitis, vascular congestion, presence of perivascular lymphoplasmacytic infiltrate and areas of focal microhemorrhage. Antigen labeling for whole forms of Leishmania amastigotes was not observed in any fragment of the CNS of the dogs of either groups; however, most of them presented labeling of blood vessels walls, which suggests the presence of circulating parasite antigens.Faculdade de Ciências Agrárias e Vaterinárias Universidade Estadual Paulista, Jaboticabal - SPDepartamento de Patologia Escola de Medicin Universidade de São Paulo, São Paulo - SPDepartamento de Clínica Cirurgia e Reprodução Animal Universidade Estadual Paulista, Araçatuba - SPFaculdade de Ciências Agrárias e Vaterinárias Universidade Estadual Paulista, Jaboticabal - SPDepartamento de Clínica Cirurgia e Reprodução Animal Universidade Estadual Paulista, Araçatuba - SPUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)2014-05-27T11:22:44Z2014-05-27T11:22:44Z2007-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5-11application/pdfhttp://www.revistas.usp.br/bjvras/article/view/26653Brazilian Journal of Veterinary Research and Animal Science, v. 44, n. 1, p. 5-11, 2007.1413-95961678-4456http://hdl.handle.net/11449/701912-s2.0-673492562142-s2.0-67349256214.pdf18179466710900100810837598202634Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporBrazilian Journal of Veterinary Research and Animal Science0,2250,225info:eu-repo/semantics/openAccessIkeda, Fabiana Augusta [UNESP]Laurenti, Márcia DalastraCorbett, Carlos EduardoFeitosa, Mary Marcondes [UNESP]Machado, Gisela Fabrino [UNESP]Perri, Silvia Helena Venturoli [UNESP]2025-06-07T05:02:53Zoai:repositorio.unesp.br:11449/70191Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-06-07T05:02:53Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
Estudo histológico e imunoistoquímico do sistema nervoso central de cães naturalmente infectados por Leishmania (Leishmania) chagasi Histological and immunohistochemical study of the central nervous system of dogs naturally infected by Leishmania (Leishmania) chagasi |
| title |
Estudo histológico e imunoistoquímico do sistema nervoso central de cães naturalmente infectados por Leishmania (Leishmania) chagasi |
| spellingShingle |
Estudo histológico e imunoistoquímico do sistema nervoso central de cães naturalmente infectados por Leishmania (Leishmania) chagasi Ikeda, Fabiana Augusta [UNESP] Central nervous system Dogs Histopathology Immunohistochemistry Leishmania chagasi Animalia Canis familiaris Leishmania donovani chagasi |
| title_short |
Estudo histológico e imunoistoquímico do sistema nervoso central de cães naturalmente infectados por Leishmania (Leishmania) chagasi |
| title_full |
Estudo histológico e imunoistoquímico do sistema nervoso central de cães naturalmente infectados por Leishmania (Leishmania) chagasi |
| title_fullStr |
Estudo histológico e imunoistoquímico do sistema nervoso central de cães naturalmente infectados por Leishmania (Leishmania) chagasi |
| title_full_unstemmed |
Estudo histológico e imunoistoquímico do sistema nervoso central de cães naturalmente infectados por Leishmania (Leishmania) chagasi |
| title_sort |
Estudo histológico e imunoistoquímico do sistema nervoso central de cães naturalmente infectados por Leishmania (Leishmania) chagasi |
| dc.creator.none.fl_str_mv |
Ikeda, Fabiana Augusta [UNESP] Laurenti, Márcia Dalastra Corbett, Carlos Eduardo Feitosa, Mary Marcondes [UNESP] Machado, Gisela Fabrino [UNESP] Perri, Silvia Helena Venturoli [UNESP] |
| author |
Ikeda, Fabiana Augusta [UNESP] |
| author_facet |
Ikeda, Fabiana Augusta [UNESP] Laurenti, Márcia Dalastra Corbett, Carlos Eduardo Feitosa, Mary Marcondes [UNESP] Machado, Gisela Fabrino [UNESP] Perri, Silvia Helena Venturoli [UNESP] |
| author_role |
author |
| author2 |
Laurenti, Márcia Dalastra Corbett, Carlos Eduardo Feitosa, Mary Marcondes [UNESP] Machado, Gisela Fabrino [UNESP] Perri, Silvia Helena Venturoli [UNESP] |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
| dc.subject.por.fl_str_mv |
Central nervous system Dogs Histopathology Immunohistochemistry Leishmania chagasi Animalia Canis familiaris Leishmania donovani chagasi |
| topic |
Central nervous system Dogs Histopathology Immunohistochemistry Leishmania chagasi Animalia Canis familiaris Leishmania donovani chagasi |
| description |
The present study aimed to characterize the histopathological alterations and to detect, by immunohistochemistry, the presence of amastigote forms of Leishmania in CNS tissue of dogs with and without neurological clinical signs of the disease. Two groups of animals were used: the first was composed of 18 dogs with visceral leishmaniasis without clinical evidence of neurological involvement, and the second, composed of 21 dogs with visceral leishmaniasis and neurological symptoms. The most frequent histopathological alterations found in the CNS of dogs of both groups were neuronal degeneration with neuronophagia, gliosis, leptomeningitis, vascular congestion, presence of perivascular lymphoplasmacytic infiltrate and areas of focal microhemorrhage. Antigen labeling for whole forms of Leishmania amastigotes was not observed in any fragment of the CNS of the dogs of either groups; however, most of them presented labeling of blood vessels walls, which suggests the presence of circulating parasite antigens. |
| publishDate |
2007 |
| dc.date.none.fl_str_mv |
2007-12-01 2014-05-27T11:22:44Z 2014-05-27T11:22:44Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://www.revistas.usp.br/bjvras/article/view/26653 Brazilian Journal of Veterinary Research and Animal Science, v. 44, n. 1, p. 5-11, 2007. 1413-9596 1678-4456 http://hdl.handle.net/11449/70191 2-s2.0-67349256214 2-s2.0-67349256214.pdf 1817946671090010 0810837598202634 |
| url |
http://www.revistas.usp.br/bjvras/article/view/26653 http://hdl.handle.net/11449/70191 |
| identifier_str_mv |
Brazilian Journal of Veterinary Research and Animal Science, v. 44, n. 1, p. 5-11, 2007. 1413-9596 1678-4456 2-s2.0-67349256214 2-s2.0-67349256214.pdf 1817946671090010 0810837598202634 |
| dc.language.iso.fl_str_mv |
por |
| language |
por |
| dc.relation.none.fl_str_mv |
Brazilian Journal of Veterinary Research and Animal Science 0,225 0,225 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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5-11 application/pdf |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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repositoriounesp@unesp.br |
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1853671573633892352 |
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15,301629 |