Multilayer microparticles for programmed sequential release of phenolic compounds from Eugenia stipitata: Stability and bioavailability

A co-delivery system based on multilayer microparticles was developed and characterized for the sequential release of phenolic compounds (PCs) using different encapsulation processes (spray drying: SD and drying-chilling spray: SDC) and wall materials to improve the stability and bioavailability of...

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Detalles Bibliográficos
Autores: Queiroz de Oliveira, Williara, Angélica Neri Numa, Iramaia, Alvim, Izabela D., Azeredo, Henriette M.C., Santos, Leticia B. [UNESP], Borsoi, Felipe T., de Araújo, Fábio F., Sawaya, Alexandra C.H.F., do Nascimento, Gustavo C., Clerici, Maria Teresa P.S., do Sacramento, Célio K., Maria Pastore, Glaucia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Brasil
Institución:Universidade Estadual Paulista (UNESP)
Repositorio:Repositório Institucional da UNESP
Idioma:inglés
OAI Identifier:oai:repositorio.unesp.br:11449/306127
Acceso en línea:http://dx.doi.org/10.1016/j.foodchem.2024.138579
https://hdl.handle.net/11449/306127
Access Level:acceso abierto
Palabra clave:Araçá-boi
Cará-roxo
Co-encapsulation
In vitro digestion
Spray chilling
Spray drying
Descripción
Sumario:A co-delivery system based on multilayer microparticles was developed and characterized for the sequential release of phenolic compounds (PCs) using different encapsulation processes (spray drying: SD and drying-chilling spray: SDC) and wall materials to improve the stability and bioavailability of PCs. Samples were characterized in terms of process yield (PY%), phenolic retention efficiency (PRE%), chemical structure and crystallinity (NMR, FTIR, DXR), thermal stability (DSC and FT-IR), anti-radical capacity (ORAC and ABTS) and in vitro digestion. PRE% of samples by SD were higher (p < 0.05) than SDC due to the formation of PCs from CRF (cará-roxo flour). NMR, FTIR, DXR confirmed the presence of key components and interactions for the formation of the advanced co-delivery system. The SDC particles showed crystalline regions by XRD and were stable at ∼47 °C. All samples showed good release of PC in the intestinal phase, and antiradical capacity that reached 23.66 µmol TE g−1.

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