Multilayer microparticles for programmed sequential release of phenolic compounds from Eugenia stipitata: Stability and bioavailability

A co-delivery system based on multilayer microparticles was developed and characterized for the sequential release of phenolic compounds (PCs) using different encapsulation processes (spray drying: SD and dryingchilling spray: SDC) and wall materials to improve the stability and bioavailability of P...

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Detalhes bibliográficos
Autores: Oliveira, Williara Queiroz de, Numa, Iramaia Angélica Neri, Alvim, Izabela D., Azeredo, Henriette M. C., Santos, Leticia B., Borsoi, Felipe T., Araújo, Fábio F. de, Sawaya, Alexandra C.H.F., Nascimento, Gustavo C. do, Clerici, Maria Teresa P.S., Sacramento, Célio K. do, Pastore, Glaucia Maria
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:Brasil
Recursos:Instituto de Tecnologia de Alimentos (ITAL)
Repositorio:Repositório do Instituto de Tecnologia de Alimentos
Idioma:inglés
OAI Identifier:oai:http://repositorio.ital.sp.gov.br:123456789/834
Acesso em linha:http://repositorio.ital.sp.gov.br/jspui/handle/123456789/834
Access Level:acceso abierto
Palavra-chave:Araçá-boi
Cara-roxo
Co-encapsulation
In vitro digestion
Spray drying
Spray chilling
Descrição
Resumo:A co-delivery system based on multilayer microparticles was developed and characterized for the sequential release of phenolic compounds (PCs) using different encapsulation processes (spray drying: SD and dryingchilling spray: SDC) and wall materials to improve the stability and bioavailability of PCs. Samples were characterized in terms of process yield (PY%), phenolic retention efficiency (PRE%), chemical structure and crystallinity (NMR, FTIR, DXR), thermal stability (DSC and FT-IR), anti-radical capacity (ORAC and ABTS) and in vitro digestion. PRE% of samples by SD were higher (p < 0.05) than SDC due to the formation of PCs from CRF (car´a-roxo flour). NMR, FTIR, DXR confirmed the presence of key components and interactions for the formation of the advanced co-delivery system. The SDC particles showed crystalline regions by XRD and were stable at ~47 ◦C. All samples showed good release of PC in the intestinal phase, and antiradical capacity that reached 23.66 µmol TE g− 1.

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