A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs

This was a cross-sectional study which analyzed the prevalence and the clinical and immunological spectrum of canine Leishmania (L.) infantum chagasi infection in a cohort of 320 mongrel dogs living in an endemic area of American visceral leishmaniasis in the Amazonian Brazil by using, mainly, the i...

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Authors: Silveira, Fernando Tobias, Carneiro, Liliane Almeida, Ramos, Patrícia Karla Santos, Chagas, Eugênia J, Lima, Luciana Vieira do Rêgo, Campos, Marliane Batista, Laurenti, Márcia Dalastra, Gomes, Claudia Maria de Castro, Corbett, Carlos Eduardo Pereira
Format: article
Status:Published version
Publication Date:2012
Country:Brasil
Institution:Instituto Evandro Chagas (IEC)
Repository:Repositório Digital do Instituto Evandro Chagas (Patuá)
Language:English
OAI Identifier:oai:patua.iec.gov.br:iec/868
Online Access:https://patua.iec.gov.br/handle/iec/868
Access Level:Open access
Keyword:Leishmania infantum / parasitologia
Leishmaniose Visceral / transmissão
Estudos Transversais
Saúde Pública
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dc.title.pt_BR.fl_str_mv A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs
title A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs
spellingShingle A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs
Silveira, Fernando Tobias
Leishmania infantum / parasitologia
Leishmaniose Visceral / transmissão
Estudos Transversais
Saúde Pública
title_short A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs
title_full A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs
title_fullStr A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs
title_full_unstemmed A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs
title_sort A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs
dc.creator.none.fl_str_mv Silveira, Fernando Tobias
Carneiro, Liliane Almeida
Ramos, Patrícia Karla Santos
Chagas, Eugênia J
Lima, Luciana Vieira do Rêgo
Campos, Marliane Batista
Laurenti, Márcia Dalastra
Gomes, Claudia Maria de Castro
Corbett, Carlos Eduardo Pereira
author Silveira, Fernando Tobias
author_facet Silveira, Fernando Tobias
Carneiro, Liliane Almeida
Ramos, Patrícia Karla Santos
Chagas, Eugênia J
Lima, Luciana Vieira do Rêgo
Campos, Marliane Batista
Laurenti, Márcia Dalastra
Gomes, Claudia Maria de Castro
Corbett, Carlos Eduardo Pereira
author_role author
author2 Carneiro, Liliane Almeida
Ramos, Patrícia Karla Santos
Chagas, Eugênia J
Lima, Luciana Vieira do Rêgo
Campos, Marliane Batista
Laurenti, Márcia Dalastra
Gomes, Claudia Maria de Castro
Corbett, Carlos Eduardo Pereira
author2_role author
author
author
author
author
author
author
author
dc.subject.decsPrimary.pt_BR.fl_str_mv Leishmania infantum / parasitologia
Leishmaniose Visceral / transmissão
Estudos Transversais
Saúde Pública
topic Leishmania infantum / parasitologia
Leishmaniose Visceral / transmissão
Estudos Transversais
Saúde Pública
description This was a cross-sectional study which analyzed the prevalence and the clinical and immunological spectrum of canine Leishmania (L.) infantum chagasi infection in a cohort of 320 mongrel dogs living in an endemic area of American visceral leishmaniasis in the Amazonian Brazil by using, mainly, the indirect fluorescence antibody test (IFAT-IgG) and the delayed-type hypersensitivity (DTH), and the parasite research by the popliteal lymph node aspiration. The IFAT and DTH reactivity recognized three different immune response profiles: (1) IFAT((+))/DTH((-)) (107 dogs), (2) IFAT((-))/DTH((+)) (18 dogs), and (3) IFAT((+))/DTH((+)) (13 dogs), providing an overall prevalence of infection of 43 per cent (138/320). Thus, the specific prevalence of IFAT( (+) )/DTH( (-) ) 33.4 per cent (107/320) was higher than those of IFAT( (-) )/DTH( (+) ) 5.6 per cent (18/320) and IFAT( (+) )/DTH( (+) ) 4.0 per cent (13/320). Moreover, the frequency of these profiles among 138 infected dogs showed that the IFAT( (+) )/DTH( (-) ) rate of 77.5 per cent (107/138) was also higher than those of 13.0 per cent (18/138) of IFAT( (-) )/DTH( (+) ) and 9.5 per cent (13/138) of IFAT( (+) )/DTH( (+) ) rates. The frequency of asymptomatic dogs (76 per cent-105) was higher than those of symptomatic (16.6 per cent-23) and oligosymptomatic ones (7.4 per cent-10). A total of 16 (11.6 per cent) L. (L.) i. chagasi isolates were obtained from infected dogs, all from the IFAT( (+) ) /DTH( (-) ) profile: 41 per cent (9/22) from symptomatic, 33.3 per cent (3/9) from oligosymptomatic, and 5.2 per cent (4/76) from asymptomatic dogs. These findings strongly suggested that despite the higher frequency of asymptomatic dogs (76 per cent-105), the majority (72.4 per cent-76) was characterized by the IFAT( (+) ) /DTH( (-) ) profile with a doubtful immunogenetic resistance against infection.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2016-01-26T11:37:00Z
dc.date.available.fl_str_mv 2016-01-26T11:37:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVEIRA, Fernando Tobias et al. A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs. Parasitology Research, v. 111, p. 1513-1522, 2012.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/868
dc.identifier.doi.-.fl_str_mv 10.1007/s00436-012-2989-4
identifier_str_mv SILVEIRA, Fernando Tobias et al. A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs. Parasitology Research, v. 111, p. 1513-1522, 2012.
10.1007/s00436-012-2989-4
url https://patua.iec.gov.br/handle/iec/868
dc.language.iso.fl_str_mv eng
language eng
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eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Springer International
publisher.none.fl_str_mv Springer International
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instacron_str IEC
institution IEC
reponame_str Repositório Digital do Instituto Evandro Chagas (Patuá)
collection Repositório Digital do Instituto Evandro Chagas (Patuá)
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spelling 2016-01-26T11:37:00Z2016-01-26T11:37:00Z2012SILVEIRA, Fernando Tobias et al. A cross-sectional study on canine Leishmania (L) infantum chagasi infection in Amazonian Brazil ratifies a higher prevalence of specific IgG-antibody response than delayed-type hypersensitivity in symptomatic and asymptomatic dogs. Parasitology Research, v. 111, p. 1513-1522, 2012.https://patua.iec.gov.br/handle/iec/86810.1007/s00436-012-2989-4This was a cross-sectional study which analyzed the prevalence and the clinical and immunological spectrum of canine Leishmania (L.) infantum chagasi infection in a cohort of 320 mongrel dogs living in an endemic area of American visceral leishmaniasis in the Amazonian Brazil by using, mainly, the indirect fluorescence antibody test (IFAT-IgG) and the delayed-type hypersensitivity (DTH), and the parasite research by the popliteal lymph node aspiration. The IFAT and DTH reactivity recognized three different immune response profiles: (1) IFAT((+))/DTH((-)) (107 dogs), (2) IFAT((-))/DTH((+)) (18 dogs), and (3) IFAT((+))/DTH((+)) (13 dogs), providing an overall prevalence of infection of 43 per cent (138/320). Thus, the specific prevalence of IFAT( (+) )/DTH( (-) ) 33.4 per cent (107/320) was higher than those of IFAT( (-) )/DTH( (+) ) 5.6 per cent (18/320) and IFAT( (+) )/DTH( (+) ) 4.0 per cent (13/320). Moreover, the frequency of these profiles among 138 infected dogs showed that the IFAT( (+) )/DTH( (-) ) rate of 77.5 per cent (107/138) was also higher than those of 13.0 per cent (18/138) of IFAT( (-) )/DTH( (+) ) and 9.5 per cent (13/138) of IFAT( (+) )/DTH( (+) ) rates. The frequency of asymptomatic dogs (76 per cent-105) was higher than those of symptomatic (16.6 per cent-23) and oligosymptomatic ones (7.4 per cent-10). A total of 16 (11.6 per cent) L. (L.) i. chagasi isolates were obtained from infected dogs, all from the IFAT( (+) ) /DTH( (-) ) profile: 41 per cent (9/22) from symptomatic, 33.3 per cent (3/9) from oligosymptomatic, and 5.2 per cent (4/76) from asymptomatic dogs. These findings strongly suggested that despite the higher frequency of asymptomatic dogs (76 per cent-105), the majority (72.4 per cent-76) was characterized by the IFAT( (+) ) /DTH( (-) ) profile with a doubtful immunogenetic resistance against infection.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Federal University of Pará. Tropical Medicine Institute. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Public Health Department. Health Care Secretary of Barcarena. Barcarena, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Medical School of São Paulo University. Pathology Department. São Paulo, SP, Brazil.Medical School of São Paulo University. Pathology Department. São Paulo, SP, Brazil.Medical School of São Paulo University. Pathology Department. 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