Libidibia ferrea loaded in bacterial nanocellulose: evaluation of antimicrobial activity and wound care / Libidibia ferrea loaded in bacterial nanocellulose: evaluation of antimicrobial activity and wound care

The effects of Bacterial Nanocellulose (BNC) loaded with Libidibia ferrea (Lf) hydroalcoholic extract were investigated on the healing process of burn in diabetic and non-diabetic animals. In vivo assay was performed with 36 male rats, with streptozotocin-induced diabetes and burns induced by contac...

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Detalles Bibliográficos
Autores: Jozala, Angela F., Santos, Julia R., Santos, Gabriela R. dos, Viroel, Fabia J. M. Viroel, Pickler, Thaisa B., Santos, Carolina Alves dos, Rebelo, Marcia A., Chaud, Marco V., Hataka, Alessandre, Grotto, Denise, Gerenutti, Marli, Nesiyama, Thaís Naomi Gonçalves
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Institución:Instituto Superior de Educação Vera Cruz (VeraCruz)
Repositorio:Revista Veras
Idioma:inglés
OAI Identifier:oai:ojs2.ojs.brazilianjournals.com.br:article/6732
Acceso en línea:https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/6732
Access Level:acceso abierto
Palabra clave:Bacterial Nanocellulose
Libidibia férrea
Wound Healing
Antimicrobial Activity.
Descripción
Sumario:The effects of Bacterial Nanocellulose (BNC) loaded with Libidibia ferrea (Lf) hydroalcoholic extract were investigated on the healing process of burn in diabetic and non-diabetic animals. In vivo assay was performed with 36 male rats, with streptozotocin-induced diabetes and burns induced by contact. Animals were divided into Nd-BNC (Non-diabetic + Bacterial nanocellulose membranes); Nd-BNC-Lf (Non-diabetic + Bacterial nanocellulose membranes + Libidibia ferrea); D-BNC (Diabetic + Bacterial nanocellulose membranes); D-BNC-Lf (Diabetic + Bacterial nanocellulose membranes + Libidibia ferrea). Wounds were evaluated for 28 days histologically. Lf extract and BNC-Lf extract showed antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli. The severe degree of infection, granulation and inflammation observed after 14 days in diabetic rats (exposed or not to Lf extract), disappeared after 21 days. On the 28th day, there was no histological difference among the groups. BNC-Lf extract demonstrated to have antimicrobial activity, however as an wound dressing, both BNC or BNC-Lf extract were effective in the healing of second-degree burn wounds.

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