Immune risk profile of elderly women with breast cancer: the first 37 cases

AIMS: To evaluate the immune risk profile of elderly women with breast cancer and to assess whether this can be a reliable predictor to determine types of treatment and oncologic follow-up. METHODS: We assessed the CD4+/CD8+ ratio in peripheral blood cell, as well as serology for cytomegalovirus, of...

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Autores: Vollbrecht, Betina, Zerwes, Felipe Pereira, Viegas, Janaina, Willers, Thiago, Ornagh, Ana Paula, Bonorino, Cristina, Frasson, Antonio Luiz
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Brasil
Recursos:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
Repositorio:Scientia Medica (Porto Alegre. Online)
Idioma:portugués
OAI Identifier:oai:ojs.revistaseletronicas.pucrs.br:article/16613
Acesso em linha:https://revistaseletronicas.pucrs.br/scientiamedica/article/view/16613
Access Level:acceso abierto
Palavra-chave:CD4-POSITIVE T-LYMPHOCYTES
CD8-POSITIVE T-LYMPHOCYTES
CD4-CD8 RATIO
BREAST CANCER/immunology
GERIATRICS.
LINFÓCITOS T CD4-POSITIVOS
LINFÓCITOS T CD8-POSITIVOS
RELAÇÃO CD4-CD8
CÂNCER DE MAMA/imunologia
GERIATRIA.
id BR_48a53ce3b858ad965df19413dac0c8ea
oai_identifier_str oai:ojs.revistaseletronicas.pucrs.br:article/16613
network_acronym_str BR
network_name_str Brasil
repository_id_str
dc.title.none.fl_str_mv Immune risk profile of elderly women with breast cancer: the first 37 cases
Perfil de risco imunológico de idosas com câncer de mama: os primeiros 37 casos
title Immune risk profile of elderly women with breast cancer: the first 37 cases
spellingShingle Immune risk profile of elderly women with breast cancer: the first 37 cases
Vollbrecht, Betina
CD4-POSITIVE T-LYMPHOCYTES
CD8-POSITIVE T-LYMPHOCYTES
CD4-CD8 RATIO
BREAST CANCER/immunology
GERIATRICS.
LINFÓCITOS T CD4-POSITIVOS
LINFÓCITOS T CD8-POSITIVOS
RELAÇÃO CD4-CD8
CÂNCER DE MAMA/imunologia
GERIATRIA.
title_short Immune risk profile of elderly women with breast cancer: the first 37 cases
title_full Immune risk profile of elderly women with breast cancer: the first 37 cases
title_fullStr Immune risk profile of elderly women with breast cancer: the first 37 cases
title_full_unstemmed Immune risk profile of elderly women with breast cancer: the first 37 cases
title_sort Immune risk profile of elderly women with breast cancer: the first 37 cases
dc.creator.none.fl_str_mv Vollbrecht, Betina
Zerwes, Felipe Pereira
Viegas, Janaina
Willers, Thiago
Ornagh, Ana Paula
Bonorino, Cristina
Frasson, Antonio Luiz
author Vollbrecht, Betina
author_facet Vollbrecht, Betina
Zerwes, Felipe Pereira
Viegas, Janaina
Willers, Thiago
Ornagh, Ana Paula
Bonorino, Cristina
Frasson, Antonio Luiz
author_role author
author2 Zerwes, Felipe Pereira
Viegas, Janaina
Willers, Thiago
Ornagh, Ana Paula
Bonorino, Cristina
Frasson, Antonio Luiz
author2_role author
author
author
author
author
author
dc.subject.por.fl_str_mv CD4-POSITIVE T-LYMPHOCYTES
CD8-POSITIVE T-LYMPHOCYTES
CD4-CD8 RATIO
BREAST CANCER/immunology
GERIATRICS.
LINFÓCITOS T CD4-POSITIVOS
LINFÓCITOS T CD8-POSITIVOS
RELAÇÃO CD4-CD8
CÂNCER DE MAMA/imunologia
GERIATRIA.
topic CD4-POSITIVE T-LYMPHOCYTES
CD8-POSITIVE T-LYMPHOCYTES
CD4-CD8 RATIO
BREAST CANCER/immunology
GERIATRICS.
LINFÓCITOS T CD4-POSITIVOS
LINFÓCITOS T CD8-POSITIVOS
RELAÇÃO CD4-CD8
CÂNCER DE MAMA/imunologia
GERIATRIA.
description AIMS: To evaluate the immune risk profile of elderly women with breast cancer and to assess whether this can be a reliable predictor to determine types of treatment and oncologic follow-up. METHODS: We assessed the CD4+/CD8+ ratio in peripheral blood cell, as well as serology for cytomegalovirus, of 37 women who were aged 60 years or more at the time they were diagnosed with breast cancer/. They all had surgical treatment at the Breast Center from Pontificia Universidade Catolica do Rio Grande do Sul. Those with positive serology for HIV, or immuno-suppressed due to organ transplant, as well as those who had neoadjuvant chemotherapy. Data was analyzed according to axillary involvement, tumor size, tumor immunohistochemical profile and occurrence of adverse events (axillary relapse, local relapse and/or metastases) RESULTS: The mean value of CD4+/CD8+ ratio was 1.72 (min. 1.1, max. 2.32) and cytomegalovirus serology was positive in all subjects. Comparing the groups, patients with positive axillary metastases (n=10) had a CD4+/CD8+ ratio greater than in those with negative axillary metastases (p=0.04). No statistically significant difference was detected regarding the size and immunohistochemical profile of the tumor. Two adverse events occurred at a mean follow-up of 14 months (one axillary relapse and one bone metastasis), when an increase in the CD4+/CD8+ ratio was observed. CONCLUSIONS: The CD4+/CD8+ ratio appear to increase in cases of breast cancer with worst prognosis. As far as was possible to search, these are the first data on CD4+ and CD8+ peripheral blood of elderly women with breast cancer. A longer follow-up will determine the value of these cells as a prognostic and/or predictive marker.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/16613
10.15448/1980-6108.2014.3.16613
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/16613
identifier_str_mv 10.15448/1980-6108.2014.3.16613
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/16613/11770
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 24 No. 3 (2014); 224-228
Scientia Medica; v. 24 n. 3 (2014); 224-228
1980-6108
1806-5562
10.15448/1980-6108.2014.3
reponame:Scientia Medica (Porto Alegre. Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Scientia Medica (Porto Alegre. Online)
collection Scientia Medica (Porto Alegre. Online)
repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
_version_ 1853665119710478336
spelling Immune risk profile of elderly women with breast cancer: the first 37 casesPerfil de risco imunológico de idosas com câncer de mama: os primeiros 37 casosCD4-POSITIVE T-LYMPHOCYTESCD8-POSITIVE T-LYMPHOCYTESCD4-CD8 RATIOBREAST CANCER/immunologyGERIATRICS.LINFÓCITOS T CD4-POSITIVOSLINFÓCITOS T CD8-POSITIVOSRELAÇÃO CD4-CD8CÂNCER DE MAMA/imunologiaGERIATRIA.AIMS: To evaluate the immune risk profile of elderly women with breast cancer and to assess whether this can be a reliable predictor to determine types of treatment and oncologic follow-up. METHODS: We assessed the CD4+/CD8+ ratio in peripheral blood cell, as well as serology for cytomegalovirus, of 37 women who were aged 60 years or more at the time they were diagnosed with breast cancer/. They all had surgical treatment at the Breast Center from Pontificia Universidade Catolica do Rio Grande do Sul. Those with positive serology for HIV, or immuno-suppressed due to organ transplant, as well as those who had neoadjuvant chemotherapy. Data was analyzed according to axillary involvement, tumor size, tumor immunohistochemical profile and occurrence of adverse events (axillary relapse, local relapse and/or metastases) RESULTS: The mean value of CD4+/CD8+ ratio was 1.72 (min. 1.1, max. 2.32) and cytomegalovirus serology was positive in all subjects. Comparing the groups, patients with positive axillary metastases (n=10) had a CD4+/CD8+ ratio greater than in those with negative axillary metastases (p=0.04). No statistically significant difference was detected regarding the size and immunohistochemical profile of the tumor. Two adverse events occurred at a mean follow-up of 14 months (one axillary relapse and one bone metastasis), when an increase in the CD4+/CD8+ ratio was observed. CONCLUSIONS: The CD4+/CD8+ ratio appear to increase in cases of breast cancer with worst prognosis. As far as was possible to search, these are the first data on CD4+ and CD8+ peripheral blood of elderly women with breast cancer. A longer follow-up will determine the value of these cells as a prognostic and/or predictive marker.OBJETIVOS: Avaliar o perfil imunológico de risco em idosas com câncer de mama e testar se este pode ser um fator preditivo confiável para determinar tipos de tratamento e seguimento oncológico. MÉTODOS: Foram pesquisadas a relação das células T CD4+/CD8+ e a sorologia para citomegalovírus no sangue periférico de mulheres com 60 anos ou mais de idade no momento do diagnóstico da neoplasia mamária, que realizaram tratamento cirúrgico no Centro de Mama da Pontifícia Universidade Católica do Rio Grande do Sul pelo Sistema Único de Saúde. Foram excluídas da pesquisa pacientes com sorologia positiva para HIV, com imunossupressão após transplante de órgãos e as que realizaram quimioterapia neoadjuvante. Os dados foram comparados em grupos conforme o comprometimento axilar, o tamanho tumoral, o perfil imunohistoquímico do tumor e a ocorrência de eventos adversos (recidiva axilar, recidiva local do tumor e/ou metástases). Nos casos de eventos adversos, foi realizada uma nova contagem de CD4+ e CD8+. RESULTADOS: Foram incluídas 37 pacientes, entre as quais 10 tiveram metástases axilares. As pacientes com axila positiva para metástases apresentaram uma relação CD4+/CD8+ maior que nos casos de axila negativa para metástases (p=0,04). Não foi encontrada diferença estatisticamente significativa em relação ao tamanho e perfil imunohistoquímico do tumor. No seguimento médio de 14,3 meses, ocorreram dois eventos adversos (uma recidiva axilar e um caso de metástases ósseas), quando se observou um aumento na relação das células T pesquisadas. CONCLUSÕES: A relação das células T CD4+/CD8+ parece aumentar nos casos de câncer de mama de pior prognóstico. Tanto quanto foi possível pesquisar na literatura, estes são os primeiros dados sobre células T CD4+ e CD8+ no sangue periférico de mulheres idosas com câncer de mama. Um seguimento maior poderá determinar o valor destas células como fator prognóstico e/ou preditivo.Editora da PUCRS - ediPUCRS2014-08-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1661310.15448/1980-6108.2014.3.16613Scientia Medica; Vol. 24 No. 3 (2014); 224-228Scientia Medica; v. 24 n. 3 (2014); 224-2281980-61081806-556210.15448/1980-6108.2014.3reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/16613/11770info:eu-repo/semantics/openAccessVollbrecht, BetinaZerwes, Felipe PereiraViegas, JanainaWillers, ThiagoOrnagh, Ana PaulaBonorino, CristinaFrasson, Antonio Luiz2017-08-28T14:51:19Zoai:ojs.revistaseletronicas.pucrs.br:article/16613Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2017-08-28T14:51:19Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
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