Protective Effect of cashew gum (Anacardium occidentale L.) on 5-Fluorouracil-induced intestinal mucositis

Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Cashew gum (CG) has been reported as a potent anti-inflammatory agent. In the present study, we aimed to evaluate the e ect of CG extracted from the exudate of Ana...

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Detalhes bibliográficos
Autores: Miranda, João Antônio Leal de, Barreto, João Erivan Façanha, Martins, Dainesy Santos, Pimentel, Paulo Vitor de Souza, Costa, Deiziane Viana da Silva, Silva, Reyca Rodrigues e, Souza, Luan Kelves Miranda de, Lima, Camila Nayane de Carvalho, Rocha, Je erson Almeida, Freitas, Ana Paula Fragoso de, Silva, Durcilene Alves da, Scafuri, Ariel Gustavo, Leitão, Renata Ferreira de Carvalho, Brito, Gerly Anne de Castro, Medeiros, Jand Venes Rolim, Cerqueira, Gilberto Santos
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:Brasil
Recursos:Universidade Federal do Ceará (UFC)
Repositório:Repositório Institucional da Universidade Federal do Ceará (UFC)
Idioma:inglês
OAI Identifier:oai:repositorio.ufc.br:riufc/42104
Acesso em linha:http://www.repositorio.ufc.br/handle/riufc/42104
Access Level:Acceso aberto
Palavra-chave:Mucosite
Mucositis
Inflammation
Inflamação
Anacardium occidentale
Descrição
Resumo:Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Cashew gum (CG) has been reported as a potent anti-inflammatory agent. In the present study, we aimed to evaluate the e ect of CG extracted from the exudate of Anacardium occidentale L. on experimental intestinal mucositis induced by 5-FU. Swiss mice were randomly divided into seven groups: Saline, 5-FU, CG 30, CG 60, CG 90, Celecoxib (CLX), and CLX + CG 90 groups. The weight of mice was measured daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis), levels of malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH), and immunohistochemical analysis of interleukin 1 beta (IL-1 ) and cyclooxygenase-2 (COX-2). 5-FU induced intense weight loss and reduction in villus height compared to the saline group. CG 90 prevented 5-FU-induced histopathological changes and decreased oxidative stress through decrease ofMDAlevels and increase of GSH concentration. CG attenuated inflammatory process by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. Our findings suggest that CG at a concentration of 90 mg/kg reverses the e ects of 5-FU-induced intestinal mucositis.

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