Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)

Garcia, Armando da Costa; Júnior, Orivaldo Teixeira de Menezes; Mariano, Lissa Apolonia; Santiago, Letícia Corrêa; Araújo, Ângela Regina [UNESP]; Monfardini, Julia Dietsche [UNESP]; Simões, Rejane de Castro; de Oliveira, André Correa; Roque, Rosemary Aparecida; Tadei, Wanderli Pedro; Teles, Helder Lopes; de Oliveira, Camila Martins

Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)

Background: Aedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract of the endophytic fungus Phomopsis sp. against the larvae of Aedes aegypti. Meth...

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Detalhes bibliográficos
Autores:	Garcia, Armando da Costa, Júnior, Orivaldo Teixeira de Menezes, Mariano, Lissa Apolonia, Santiago, Letícia Corrêa, Araújo, Ângela Regina [UNESP], Monfardini, Julia Dietsche [UNESP], Simões, Rejane de Castro, de Oliveira, André Correa, Roque, Rosemary Aparecida, Tadei, Wanderli Pedro, Teles, Helder Lopes, de Oliveira, Camila Martins
Formato:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	Brasil
Recursos:	Universidade Estadual Paulista (UNESP)
Repositorio:	Repositório Institucional da UNESP
Idioma:	inglés
OAI Identifier:	oai:repositorio.unesp.br:11449/249316
Acesso em linha:	http://dx.doi.org/10.1590/0037-8682-0018-2022 http://hdl.handle.net/11449/249316
Access Level:	acceso abierto
Palavra-chave:	Biomonitored chemical Dengue Secondary metabolite

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network_acronym_str	BR
network_name_str	Brasil
repository_id_str
spelling	Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)Biomonitored chemicalDengueSecondary metaboliteBackground: Aedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract of the endophytic fungus Phomopsis sp. against the larvae of Aedes aegypti. Methods: Crude extract, fractions, and isolated substances were evaluated in in-vitro assays against third-stage larvae of Aedes aegypti. Results: We isolated 3-nitropropionic acid with an LC50 of 15.172 ppm and LC90 of 18.178 ppm after 24 hours of larval exposure. Conclusions: The results indicated that 3-nitropropionic acid exerted larvicidal activity.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal do Amazonas Instituto de Ciências Exatas e Tecnologia, AMUniversidade Estadual Paulista Júlio de Mesquita Filho, SPInstituto Nacional de Pesquisas da Amazônia, AMUniversidade Federal de Rondonópolis Instituto de Ciências Exatas e Naturais, MTUniversidade Estadual Paulista Júlio de Mesquita Filho, SPInstituto de Ciências Exatas e TecnologiaUniversidade Estadual Paulista (UNESP)Instituto Nacional de Pesquisas da AmazôniaInstituto de Ciências Exatas e Naturais2023-07-29T15:12:46Z2023-07-29T15:12:46Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/0037-8682-0018-2022Revista da Sociedade Brasileira de Medicina Tropical, v. 55.0037-8682http://hdl.handle.net/11449/24931610.1590/0037-8682-0018-20222-s2.0-85140856637Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista da Sociedade Brasileira de Medicina Tropicalinfo:eu-repo/semantics/openAccessGarcia, Armando da CostaJúnior, Orivaldo Teixeira de MenezesMariano, Lissa ApoloniaSantiago, Letícia CorrêaAraújo, Ângela Regina [UNESP]Monfardini, Julia Dietsche [UNESP]Simões, Rejane de Castrode Oliveira, André CorreaRoque, Rosemary AparecidaTadei, Wanderli PedroTeles, Helder Lopesde Oliveira, Camila Martins2025-05-28T07:59:57Zoai:repositorio.unesp.br:11449/249316Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-05-28T07:59:57Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv	Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)
title	Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)
spellingShingle	Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae) Garcia, Armando da Costa Biomonitored chemical Dengue Secondary metabolite
title_short	Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)
title_full	Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)
title_fullStr	Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)
title_full_unstemmed	Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)
title_sort	Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)
dc.creator.none.fl_str_mv	Garcia, Armando da Costa Júnior, Orivaldo Teixeira de Menezes Mariano, Lissa Apolonia Santiago, Letícia Corrêa Araújo, Ângela Regina [UNESP] Monfardini, Julia Dietsche [UNESP] Simões, Rejane de Castro de Oliveira, André Correa Roque, Rosemary Aparecida Tadei, Wanderli Pedro Teles, Helder Lopes de Oliveira, Camila Martins
author	Garcia, Armando da Costa
author_facet	Garcia, Armando da Costa Júnior, Orivaldo Teixeira de Menezes Mariano, Lissa Apolonia Santiago, Letícia Corrêa Araújo, Ângela Regina [UNESP] Monfardini, Julia Dietsche [UNESP] Simões, Rejane de Castro de Oliveira, André Correa Roque, Rosemary Aparecida Tadei, Wanderli Pedro Teles, Helder Lopes de Oliveira, Camila Martins
author_role	author
author2	Júnior, Orivaldo Teixeira de Menezes Mariano, Lissa Apolonia Santiago, Letícia Corrêa Araújo, Ângela Regina [UNESP] Monfardini, Julia Dietsche [UNESP] Simões, Rejane de Castro de Oliveira, André Correa Roque, Rosemary Aparecida Tadei, Wanderli Pedro Teles, Helder Lopes de Oliveira, Camila Martins
author2_role	author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Instituto de Ciências Exatas e Tecnologia Universidade Estadual Paulista (UNESP) Instituto Nacional de Pesquisas da Amazônia Instituto de Ciências Exatas e Naturais
dc.subject.por.fl_str_mv	Biomonitored chemical Dengue Secondary metabolite
topic	Biomonitored chemical Dengue Secondary metabolite
description	Background: Aedes aegypti is the primary vector of viruses, such as Zika, chikungunya, yellow fever, and dengue. In this context, a biomonitored chemical study was conducted to evaluate the activity of the crude extract of the endophytic fungus Phomopsis sp. against the larvae of Aedes aegypti. Methods: Crude extract, fractions, and isolated substances were evaluated in in-vitro assays against third-stage larvae of Aedes aegypti. Results: We isolated 3-nitropropionic acid with an LC50 of 15.172 ppm and LC90 of 18.178 ppm after 24 hours of larval exposure. Conclusions: The results indicated that 3-nitropropionic acid exerted larvicidal activity.
publishDate	2022
dc.date.none.fl_str_mv	2022-01-01 2023-07-29T15:12:46Z 2023-07-29T15:12:46Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.uri.fl_str_mv	http://dx.doi.org/10.1590/0037-8682-0018-2022 Revista da Sociedade Brasileira de Medicina Tropical, v. 55. 0037-8682 http://hdl.handle.net/11449/249316 10.1590/0037-8682-0018-2022 2-s2.0-85140856637
url	http://dx.doi.org/10.1590/0037-8682-0018-2022 http://hdl.handle.net/11449/249316
identifier_str_mv	Revista da Sociedade Brasileira de Medicina Tropical, v. 55. 0037-8682 10.1590/0037-8682-0018-2022 2-s2.0-85140856637
dc.language.iso.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	Revista da Sociedade Brasileira de Medicina Tropical
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP
instname_str	Universidade Estadual Paulista (UNESP)
instacron_str	UNESP
institution	UNESP
reponame_str	Repositório Institucional da UNESP
collection	Repositório Institucional da UNESP
repository.name.fl_str_mv	Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv	repositoriounesp@unesp.br
_version_	1853672375186358272
score	15,198674

Endophytic fungus Phomopsis sp. as a source of 3-nitropropionic acid with larvicidal activity against Aedes aegypti (Linnaeus 1762, Diptera: Culicidae)

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