HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing

HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, promotes miRNA biogenesis by stabilizing a complex between DCL1 and Mediator...

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Authors: Cambiagno, Damián Alejandro, Giudicatti, Axel Joel, Arce, Agustín Lucas, Gagliardi, Delfina, Li, Lei, Yuan, Wei, Lundberg, Derek S., Weigel, Detlef, Manavella, Pablo Andrés
Format: article
Status:Published version
Publication Date:2021
Country:Argentina
Institution:Consejo Nacional de Investigaciones Científicas y Técnicas
Repository:CONICET Digital (CONICET)
Language:English
OAI Identifier:oai:ri.conicet.gov.ar:11336/145316
Online Access:http://hdl.handle.net/11336/145316
Access Level:Open access
Keyword:GENE SILENCING
HASTY
MICRORNA
MIRNA BIOGENESIS
MIRNA NUCLEAR EXPORT
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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oai_identifier_str oai:ri.conicet.gov.ar:11336/145316
network_acronym_str AR
network_name_str Argentina
repository_id_str
spelling HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processingCambiagno, Damián AlejandroGiudicatti, Axel JoelArce, Agustín LucasGagliardi, DelfinaLi, LeiYuan, WeiLundberg, Derek S.Weigel, DetlefManavella, Pablo AndrésGENE SILENCINGHASTYMICRORNAMIRNA BIOGENESISMIRNA NUCLEAR EXPORThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, promotes miRNA biogenesis by stabilizing a complex between DCL1 and Mediator at MIRNA loci, thereby acting as a linker between pri-miRNA transcription and processing.Fil: Cambiagno, Damián Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; ArgentinaFil: Giudicatti, Axel Joel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; ArgentinaFil: Arce, Agustín Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; ArgentinaFil: Gagliardi, Delfina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; ArgentinaFil: Li, Lei. Institut Max Planck Fuer Gesellschaft. Institut Fur Entwicklungsbiolobie. Developmental Biology; AlemaniaFil: Yuan, Wei. Institut Max Planck Fuer Gesellschaft. Institut Fur Entwicklungsbiolobie. Developmental Biology; AlemaniaFil: Lundberg, Derek S.. Institut Max Planck Fuer Gesellschaft. Institut Fur Entwicklungsbiolobie. Developmental Biology; AlemaniaFil: Weigel, Detlef. Institut Max Planck Fuer Gesellschaft. Institut Fur Entwicklungsbiolobie. Developmental Biology; AlemaniaFil: Manavella, Pablo Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Agrobiotecnología del Litoral. Universidad Nacional del Litoral. Instituto de Agrobiotecnología del Litoral; ArgentinaOxford University Press2021-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/145316Cambiagno, Damián Alejandro; Giudicatti, Axel Joel; Arce, Agustín Lucas; Gagliardi, Delfina; Li, Lei; et al.; HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing; Oxford University Press; Molecular Plant; 14; 3; 3-2021; 426-4391674-2052CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1674205220304500info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molp.2020.12.019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2024-05-08T13:45:58Zoai:ri.conicet.gov.ar:11336/145316instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982024-05-08 13:45:58.562CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing
title HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing
spellingShingle HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing
Cambiagno, Damián Alejandro
GENE SILENCING
HASTY
MICRORNA
MIRNA BIOGENESIS
MIRNA NUCLEAR EXPORT
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing
title_full HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing
title_fullStr HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing
title_full_unstemmed HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing
title_sort HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing
dc.creator.none.fl_str_mv Cambiagno, Damián Alejandro
Giudicatti, Axel Joel
Arce, Agustín Lucas
Gagliardi, Delfina
Li, Lei
Yuan, Wei
Lundberg, Derek S.
Weigel, Detlef
Manavella, Pablo Andrés
author Cambiagno, Damián Alejandro
author_facet Cambiagno, Damián Alejandro
Giudicatti, Axel Joel
Arce, Agustín Lucas
Gagliardi, Delfina
Li, Lei
Yuan, Wei
Lundberg, Derek S.
Weigel, Detlef
Manavella, Pablo Andrés
author_role author
author2 Giudicatti, Axel Joel
Arce, Agustín Lucas
Gagliardi, Delfina
Li, Lei
Yuan, Wei
Lundberg, Derek S.
Weigel, Detlef
Manavella, Pablo Andrés
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv GENE SILENCING
HASTY
MICRORNA
MIRNA BIOGENESIS
MIRNA NUCLEAR EXPORT
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic GENE SILENCING
HASTY
MICRORNA
MIRNA BIOGENESIS
MIRNA NUCLEAR EXPORT
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, promotes miRNA biogenesis by stabilizing a complex between DCL1 and Mediator at MIRNA loci, thereby acting as a linker between pri-miRNA transcription and processing.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/145316
Cambiagno, Damián Alejandro; Giudicatti, Axel Joel; Arce, Agustín Lucas; Gagliardi, Delfina; Li, Lei; et al.; HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing; Oxford University Press; Molecular Plant; 14; 3; 3-2021; 426-439
1674-2052
CONICET Digital
CONICET
url http://hdl.handle.net/11336/145316
identifier_str_mv Cambiagno, Damián Alejandro; Giudicatti, Axel Joel; Arce, Agustín Lucas; Gagliardi, Delfina; Li, Lei; et al.; HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing; Oxford University Press; Molecular Plant; 14; 3; 3-2021; 426-439
1674-2052
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1674205220304500
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molp.2020.12.019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1799195199833899008
score 15.228081

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