HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing

HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, promotes miRNA biogenesis by stabilizing a complex between DCL1 and Mediator...

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Detalhes bibliográficos
Autores: Cambiagno, Damián Alejandro, Giudicatti, Axel Joel, Arce, Agustín Lucas, Gagliardi, Delfina, Li, Lei, Yuan, Wei, Lundberg, Derek S., Weigel, Detlef, Manavella, Pablo Andrés
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/145316
Acesso em linha:http://hdl.handle.net/11336/145316
Access Level:acceso abierto
Palavra-chave:GENE SILENCING
HASTY
MICRORNA
MIRNA BIOGENESIS
MIRNA NUCLEAR EXPORT
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
Descrição
Resumo:HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, promotes miRNA biogenesis by stabilizing a complex between DCL1 and Mediator at MIRNA loci, thereby acting as a linker between pri-miRNA transcription and processing.

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