Ultrastructure of STH cells in the pars distalis of the hypophysis of mice bearing transplanted hepatomas

An electron microscopic analysis was performed on the pars distalis of the hypophysis of mice bearing transplanted hepatomas. Normal mice served as controls. In animals bearing a fast growing as well as in those bearing a slow growing hepatoma, the STH cells presented changes indicating increased re...

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Detalhes bibliográficos
Autores: Badrán, Amado F., Nash, R. E., Echave Llanos, Julián Miguel
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:1971
País:Argentina
Recursos:Universidad Nacional de La Plata
Repositório:SEDICI (UNLP)
Idioma:inglês
OAI Identifier:oai:sedici.unlp.edu.ar:10915/140861
Acesso em linha:http://sedici.unlp.edu.ar/handle/10915/140861
Access Level:Acceso aberto
Palavra-chave:Medicina
Biología
Hypophysis
Mouse
Pars distalis
STH cells
Hepatomas
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spelling Ultrastructure of STH cells in the pars distalis of the hypophysis of mice bearing transplanted hepatomasBadrán, Amado F.Nash, R. E.Echave Llanos, Julián MiguelMedicinaBiologíaHypophysisMousePars distalisSTH cellsHepatomasAn electron microscopic analysis was performed on the pars distalis of the hypophysis of mice bearing transplanted hepatomas. Normal mice served as controls. In animals bearing a fast growing as well as in those bearing a slow growing hepatoma, the STH cells presented changes indicating increased release and synthesis of its secretory product. These changes can be summarized as follows: 1) Increased number of granuledepleted STH cells which were very irregular in size and shape. 2) Very irregular and sometimes bizarre nuclei. 3) Plasma membranes irregular and convoluted. 4) Increased quantity of endoplasmic reticulum which appeared sometimes dilated and contained material of varying electron density. 5) Abundant, irregular and frequently ramified mitochondria. 6) Hypertrophic Golgi system with increased number of microvesicles. 7) Increased number of large lysosomes of different type. 8) Increased number of fat droplets.Facultad de Ciencias Médicas1971info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdf525-531http://sedici.unlp.edu.ar/handle/10915/140861enginfo:eu-repo/semantics/altIdentifier/issn/0340-0336info:eu-repo/semantics/altIdentifier/doi/10.1007/bf00324618info:eu-repo/semantics/altIdentifier/pmid/4327630info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/Creative Commons Attribution 4.0 International (CC BY 4.0)reponame:SEDICI (UNLP)instname:Universidad Nacional de La Platainstacron:UNLP2024-05-08T13:10:32Zoai:sedici.unlp.edu.ar:10915/140861Institucionalhttp://sedici.unlp.edu.ar/Universidad públicaNo correspondehttp://sedici.unlp.edu.ar/oai/snrdalira@sedici.unlp.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:13292024-05-08 13:10:32.888SEDICI (UNLP) - Universidad Nacional de La Platafalse
dc.title.none.fl_str_mv Ultrastructure of STH cells in the pars distalis of the hypophysis of mice bearing transplanted hepatomas
title Ultrastructure of STH cells in the pars distalis of the hypophysis of mice bearing transplanted hepatomas
spellingShingle Ultrastructure of STH cells in the pars distalis of the hypophysis of mice bearing transplanted hepatomas
Badrán, Amado F.
Medicina
Biología
Hypophysis
Mouse
Pars distalis
STH cells
Hepatomas
title_short Ultrastructure of STH cells in the pars distalis of the hypophysis of mice bearing transplanted hepatomas
title_full Ultrastructure of STH cells in the pars distalis of the hypophysis of mice bearing transplanted hepatomas
title_fullStr Ultrastructure of STH cells in the pars distalis of the hypophysis of mice bearing transplanted hepatomas
title_full_unstemmed Ultrastructure of STH cells in the pars distalis of the hypophysis of mice bearing transplanted hepatomas
title_sort Ultrastructure of STH cells in the pars distalis of the hypophysis of mice bearing transplanted hepatomas
dc.creator.none.fl_str_mv Badrán, Amado F.
Nash, R. E.
Echave Llanos, Julián Miguel
author Badrán, Amado F.
author_facet Badrán, Amado F.
Nash, R. E.
Echave Llanos, Julián Miguel
author_role author
author2 Nash, R. E.
Echave Llanos, Julián Miguel
author2_role author
author
dc.subject.none.fl_str_mv Medicina
Biología
Hypophysis
Mouse
Pars distalis
STH cells
Hepatomas
topic Medicina
Biología
Hypophysis
Mouse
Pars distalis
STH cells
Hepatomas
description An electron microscopic analysis was performed on the pars distalis of the hypophysis of mice bearing transplanted hepatomas. Normal mice served as controls. In animals bearing a fast growing as well as in those bearing a slow growing hepatoma, the STH cells presented changes indicating increased release and synthesis of its secretory product. These changes can be summarized as follows: 1) Increased number of granuledepleted STH cells which were very irregular in size and shape. 2) Very irregular and sometimes bizarre nuclei. 3) Plasma membranes irregular and convoluted. 4) Increased quantity of endoplasmic reticulum which appeared sometimes dilated and contained material of varying electron density. 5) Abundant, irregular and frequently ramified mitochondria. 6) Hypertrophic Golgi system with increased number of microvesicles. 7) Increased number of large lysosomes of different type. 8) Increased number of fat droplets.
publishDate 1971
dc.date.none.fl_str_mv 1971
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Articulo
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://sedici.unlp.edu.ar/handle/10915/140861
url http://sedici.unlp.edu.ar/handle/10915/140861
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/issn/0340-0336
info:eu-repo/semantics/altIdentifier/doi/10.1007/bf00324618
info:eu-repo/semantics/altIdentifier/pmid/4327630
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
Creative Commons Attribution 4.0 International (CC BY 4.0)
dc.format.none.fl_str_mv application/pdf
525-531
dc.source.none.fl_str_mv reponame:SEDICI (UNLP)
instname:Universidad Nacional de La Plata
instacron:UNLP
instname_str Universidad Nacional de La Plata
instacron_str UNLP
institution UNLP
reponame_str SEDICI (UNLP)
collection SEDICI (UNLP)
repository.name.fl_str_mv SEDICI (UNLP) - Universidad Nacional de La Plata
repository.mail.fl_str_mv alira@sedici.unlp.edu.ar
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