LACK OF GENOTOXICITY OF SACCHARIN AND SODIUM SACCHARIN STUDIED IN THE DROSOPHILA WING SPOT AND SEX-LINKED RECESSIVE LETHAL TESTS
Two non-nutritive sweeteners, saccharin and sodiurn saccharin, were tested for their genotoxicity in the Drosophila wing spot assay and the sex-linked recessive lethal test. 72-hours and 48-hours-old lame, transheterozygous for the recessive wing cell markers mwh(multiple wing hairs) and fir'3(...
| Autores: | , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2012 |
| País: | México |
| Recursos: | UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO |
| Repositório: | Revista Internacional de Contaminación Ambiental |
| Idioma: | espanhol |
| OAI Identifier: | oai:ojs.pkp.sfu.ca:article/30502 |
| Acesso em linha: | https://www.revistascca.unam.mx/rica/index.php/rica/article/view/30502 |
| Access Level: | Acceso aberto |
| Palavra-chave: | genotoxicity Drosophila wing mosaic test sex-linked recessive lethal test saccharin sodium saccharin larval feeding |
| Resumo: | Two non-nutritive sweeteners, saccharin and sodiurn saccharin, were tested for their genotoxicity in the Drosophila wing spot assay and the sex-linked recessive lethal test. 72-hours and 48-hours-old lame, transheterozygous for the recessive wing cell markers mwh(multiple wing hairs) and fir'3(flare) from high bioactivation strains (ORR) of Drosophila melanogmterwere exposed to various concentrations of the test compounds for the rest of the larval life. The sex-linked recessive lethal test was performed following the standard technique using the Basc strain. Both compounds were non-genotoxic in the wing primordia and in the male germ line. |
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