Antiprotozoal activity of Betulinic acid derivatives

Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying...

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Detalhes bibliográficos
Autor: LUIS MANUEL PEÑA RODRIGUEZ
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:México
Recursos:Centro de Investigación Científica de Yucatán
Repositorio:Repositorio Institucional CICY
Idioma:inglés
OAI Identifier:oai:cicy.repositorioinstitucional.mx:1003/114
Acesso em linha:http://cicy.repositorioinstitucional.mx/jspui/handle/1003/114
Access Level:acceso abierto
Palavra-chave:info:eu-repo/classification/cti/6
Descrição
Resumo:Betulinic acid (1), isolated from the crude extract of the leaves of Pentalinon andrieuxii (Apocynaceae), together with betulinic acid acetate (2), betulonic acid (3), betulinic acid methyl ester (4), and betulin (5) were evaluated for their antiprotozoal activity. The results showed that modifying the C-3 position increases leishmanicidal activity while modification of the C-3 and C-28 positions decreases trypanocidal activity.