Retention of fatty acyl desaturase 1 (fads1) in elopomorpha and cyclostomata provides novel insights into the evolution of long-chain polyunsaturated fatty acid biosynthesis in vertebrates

[Background] Provision of long-chain polyunsaturated fatty acids (LC-PUFA) in vertebrates occurs through the diet or via endogenous production from C18 precursors through consecutive elongations and desaturations. It has been postulated that the abundance of LC-PUFA in the marine environment has rem...

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Bibliographic Details
Authors: Lopes-Marques, Mónica, Kabeya, Naoki, Qian, Yu, Ruivo, Raquel, Santos, Miguel M., Venkatesh, Byrappa, Tocher, Douglas R., Castro, L. Filipe C., Monroig, Óscar
Format: article
Status:Published version
Publication Date:2018
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/171299
Online Access:http://hdl.handle.net/10261/171299
Access Level:Open access
Keyword:Biosynthesis
Fatty acyl desaturase
Gene duplication
Gene loss
Long-chain polyunsaturated fatty acids
Description
Summary:[Background] Provision of long-chain polyunsaturated fatty acids (LC-PUFA) in vertebrates occurs through the diet or via endogenous production from C18 precursors through consecutive elongations and desaturations. It has been postulated that the abundance of LC-PUFA in the marine environment has remarkably modulated the gene complement and function of Fads in marine teleosts. In vertebrates two fatty acyl desaturases, namely Fads1 and Fads2, encode ∆5 and ∆6 desaturases, respectively. To fully clarify the evolutionary history of LC-PUFA biosynthesis in vertebrates, we investigated the gene repertoire and function of Fads from species placed at key evolutionary nodes.

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