Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza

Background. In most seasons, the influenza vaccine is effective in preventing influenza, but it is not clear whether it is equally effective in preventing mild and severe cases. We designed a case-control study to compare the effectiveness of the influenza vaccine in preventing outpatient, inpatient...

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Autores: Castilla, J, Godoy, P, Dominguez, A, Martinez-Baz, I, Astray, J, Martin, V, Delgado-Rodriguez, M, Baricot, M, Soldevila, N, Mayoral, JM, Quintana, JM, Galan, JC, Castro, A, Gonzalez-Candelas, F, Garin, O, Saez, M, Tamames, S, Pumarola, T, Bonfill X., López-Contreras J., Pomar V., Puig T., CIBERESP Cases Controls Influenza
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p9800
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9800
Access Level:acceso abierto
Palavra-chave:influenza virus
influenza vaccine
vaccine effectiveness
severe influenza
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spelling Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed InfluenzaCastilla, JGodoy, PDominguez, AMartinez-Baz, IAstray, JMartin, VDelgado-Rodriguez, MBaricot, MSoldevila, NMayoral, JMQuintana, JMGalan, JCCastro, AGonzalez-Candelas, FGarin, OSaez, MTamames, SPumarola, TBonfill X.López-Contreras J.Pomar V.Puig T.CIBERESP Cases Controls Influenzainfluenza virusinfluenza vaccinevaccine effectivenesssevere influenzaBackground. In most seasons, the influenza vaccine is effective in preventing influenza, but it is not clear whether it is equally effective in preventing mild and severe cases. We designed a case-control study to compare the effectiveness of the influenza vaccine in preventing outpatient, inpatient, and severe or fatal cases of laboratory-confirmed influenza. Methods. Hospitalized patients (n = 691) with laboratory-confirmed influenza in the 2010-2011 season recruited in 29 Spanish hospitals were individually matched by age, admission/visit date, and province with an outpatient with laboratory-confirmed influenza and an outpatient control. Severe cases were considered those patients admitted to intensive care units or who died in the hospital (n = 177). We compared the influenza vaccine status of controls and outpatient cases, inpatient cases, and severe cases using conditional logistic regression adjusted for potential confounding factors. Severe and nonsevere inpatient influenza cases were compared using unconditional logistic regression. Vaccine effectiveness was (1 - odds ratio) x 100. Results. Vaccine effectiveness was 75% (adjusted odds ratio [AOR], 0.25; 95% confidence interval [CI],.16-.39) in preventing influenza outpatient cases, 60% (AOR, 0.40; 95% CI,.25-.63) in preventing influenza-associated hospitalizations, and 89% (AOR, 0.11; 95% CI,.04-.37) in preventing severe cases. In inpatients, influenza vaccination was associated with a lower risk of severe influenza (AOR, 0.42; 95% CI,.22-.80). Conclusions. Influenza vaccination prevented influenza cases and hospitalizations and was associated with a better prognosis in inpatients with influenza. The combined effect of these 2 mechanisms would explain the high effectiveness of the vaccine in preventing severe cases due to influenza.OXFORD UNIV PRESS INC2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9800CLINICAL INFECTIOUS DISEASESISSN: 10584838ISSNe: 15376591reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p98002026-06-14T12:41:47Z
dc.title.none.fl_str_mv Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza
title Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza
spellingShingle Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza
Castilla, J
influenza virus
influenza vaccine
vaccine effectiveness
severe influenza
title_short Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza
title_full Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza
title_fullStr Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza
title_full_unstemmed Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza
title_sort Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza
dc.creator.none.fl_str_mv Castilla, J
Godoy, P
Dominguez, A
Martinez-Baz, I
Astray, J
Martin, V
Delgado-Rodriguez, M
Baricot, M
Soldevila, N
Mayoral, JM
Quintana, JM
Galan, JC
Castro, A
Gonzalez-Candelas, F
Garin, O
Saez, M
Tamames, S
Pumarola, T
Bonfill X.
López-Contreras J.
Pomar V.
Puig T.
CIBERESP Cases Controls Influenza
author Castilla, J
author_facet Castilla, J
Godoy, P
Dominguez, A
Martinez-Baz, I
Astray, J
Martin, V
Delgado-Rodriguez, M
Baricot, M
Soldevila, N
Mayoral, JM
Quintana, JM
Galan, JC
Castro, A
Gonzalez-Candelas, F
Garin, O
Saez, M
Tamames, S
Pumarola, T
Bonfill X.
López-Contreras J.
Pomar V.
Puig T.
CIBERESP Cases Controls Influenza
author_role author
author2 Godoy, P
Dominguez, A
Martinez-Baz, I
Astray, J
Martin, V
Delgado-Rodriguez, M
Baricot, M
Soldevila, N
Mayoral, JM
Quintana, JM
Galan, JC
Castro, A
Gonzalez-Candelas, F
Garin, O
Saez, M
Tamames, S
Pumarola, T
Bonfill X.
López-Contreras J.
Pomar V.
Puig T.
CIBERESP Cases Controls Influenza
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv influenza virus
influenza vaccine
vaccine effectiveness
severe influenza
topic influenza virus
influenza vaccine
vaccine effectiveness
severe influenza
description Background. In most seasons, the influenza vaccine is effective in preventing influenza, but it is not clear whether it is equally effective in preventing mild and severe cases. We designed a case-control study to compare the effectiveness of the influenza vaccine in preventing outpatient, inpatient, and severe or fatal cases of laboratory-confirmed influenza. Methods. Hospitalized patients (n = 691) with laboratory-confirmed influenza in the 2010-2011 season recruited in 29 Spanish hospitals were individually matched by age, admission/visit date, and province with an outpatient with laboratory-confirmed influenza and an outpatient control. Severe cases were considered those patients admitted to intensive care units or who died in the hospital (n = 177). We compared the influenza vaccine status of controls and outpatient cases, inpatient cases, and severe cases using conditional logistic regression adjusted for potential confounding factors. Severe and nonsevere inpatient influenza cases were compared using unconditional logistic regression. Vaccine effectiveness was (1 - odds ratio) x 100. Results. Vaccine effectiveness was 75% (adjusted odds ratio [AOR], 0.25; 95% confidence interval [CI],.16-.39) in preventing influenza outpatient cases, 60% (AOR, 0.40; 95% CI,.25-.63) in preventing influenza-associated hospitalizations, and 89% (AOR, 0.11; 95% CI,.04-.37) in preventing severe cases. In inpatients, influenza vaccination was associated with a lower risk of severe influenza (AOR, 0.42; 95% CI,.22-.80). Conclusions. Influenza vaccination prevented influenza cases and hospitalizations and was associated with a better prognosis in inpatients with influenza. The combined effect of these 2 mechanisms would explain the high effectiveness of the vaccine in preventing severe cases due to influenza.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9800
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9800
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OXFORD UNIV PRESS INC
publisher.none.fl_str_mv OXFORD UNIV PRESS INC
dc.source.none.fl_str_mv CLINICAL INFECTIOUS DISEASES
ISSN: 10584838
ISSNe: 15376591
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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