Biomarkers associated with sedentary behaviour in older adults

Objective Pathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults. Methods Electronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with o...

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Autores: Wirth, Katharina, Klenk, Jochen|||0000-0002-5987-447X, Brefka, Simone, Dallmeier, Dhayana|||0000-0003-3665-7023, Faehling, Kathrin, Roqué i Figuls, Marta|||0000-0003-0043-1364, Tully, Mark|||0000-0001-9710-4014, Giné-Garriga, Maria|||0000-0003-4449-3524, Caserotti, Paolo|||0000-0002-0476-5786, Salvà Casanovas, Antonio|||0000-0001-6328-3261, Rothenbacher, Dietrich|||0000-0002-3563-2791, Denkinger, Michael|||0000-0002-8097-060X, Stubbs, Brendon
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:257908
Acceso en línea:https://ddd.uab.cat/record/257908
https://dx.doi.org/urn:doi:10.1016/j.arr.2016.12.002
Access Level:acceso abierto
Palabra clave:Older adults
Sedentary behaviour
Biomarker
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spelling Biomarkers associated with sedentary behaviour in older adultsA systematic reviewWirth, KatharinaKlenk, Jochen|||0000-0002-5987-447XBrefka, SimoneDallmeier, Dhayana|||0000-0003-3665-7023Faehling, KathrinRoqué i Figuls, Marta|||0000-0003-0043-1364Tully, Mark|||0000-0001-9710-4014Giné-Garriga, Maria|||0000-0003-4449-3524Caserotti, Paolo|||0000-0002-0476-5786Salvà Casanovas, Antonio|||0000-0001-6328-3261Rothenbacher, Dietrich|||0000-0002-3563-2791Denkinger, Michael|||0000-0002-8097-060XStubbs, BrendonOlder adultsSedentary behaviourBiomarkerObjective Pathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults. Methods Electronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with objective or subjective measures of SB, sample size ≥50, mean age ≥60 years and accelerometer wear time ≥3 days. Methodological quality was appraised with the CASP tool. The protocol was pre-specified (PROSPERO CRD42015023731). Results 12701 abstracts were retrieved, 275 full text articles further explored, from which 249 were excluded. In the final sample (26 articles) a total of 63 biomarkers were detected. Most investigated markers were: body mass index (BMI, n = 15), waist circumference (WC, n = 15), blood pressure (n = 11), triglycerides (n = 12) and high density lipoprotein (HDL, n = 15). Some inflammation markers were identified such as interleukin-6, C-reactive protein or tumor necrosis factor alpha. There was a lack of renal, muscle or bone biomarkers. Randomized controlled trials found a positive correlation for SB with BMI, neck circumference, fat mass, HbA1C, cholesterol and insulin levels, cohort studies additionally for WC, leptin, C-peptide, ApoA1 and Low density lipoprotein and a negative correlation for HDL. Conclusion Most studied biomarkers associated with SB were of cardiovascular or metabolic origin. There is a suggestion of a negative impact of SB on biomarkers but still a paucity of high quality investigations exist. Longitudinal studies with objectively measured SB are needed to further elucidate the pathophysiological pathways and possible associations of unexplored biomarkers. 22017-01-0120172017-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/257908https://dx.doi.org/urn:doi:10.1016/j.arr.2016.12.002reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 634270open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2579082026-06-06T12:50:31Z
dc.title.none.fl_str_mv Biomarkers associated with sedentary behaviour in older adults
A systematic review
title Biomarkers associated with sedentary behaviour in older adults
spellingShingle Biomarkers associated with sedentary behaviour in older adults
Wirth, Katharina
Older adults
Sedentary behaviour
Biomarker
title_short Biomarkers associated with sedentary behaviour in older adults
title_full Biomarkers associated with sedentary behaviour in older adults
title_fullStr Biomarkers associated with sedentary behaviour in older adults
title_full_unstemmed Biomarkers associated with sedentary behaviour in older adults
title_sort Biomarkers associated with sedentary behaviour in older adults
dc.creator.none.fl_str_mv Wirth, Katharina
Klenk, Jochen|||0000-0002-5987-447X
Brefka, Simone
Dallmeier, Dhayana|||0000-0003-3665-7023
Faehling, Kathrin
Roqué i Figuls, Marta|||0000-0003-0043-1364
Tully, Mark|||0000-0001-9710-4014
Giné-Garriga, Maria|||0000-0003-4449-3524
Caserotti, Paolo|||0000-0002-0476-5786
Salvà Casanovas, Antonio|||0000-0001-6328-3261
Rothenbacher, Dietrich|||0000-0002-3563-2791
Denkinger, Michael|||0000-0002-8097-060X
Stubbs, Brendon
author Wirth, Katharina
author_facet Wirth, Katharina
Klenk, Jochen|||0000-0002-5987-447X
Brefka, Simone
Dallmeier, Dhayana|||0000-0003-3665-7023
Faehling, Kathrin
Roqué i Figuls, Marta|||0000-0003-0043-1364
Tully, Mark|||0000-0001-9710-4014
Giné-Garriga, Maria|||0000-0003-4449-3524
Caserotti, Paolo|||0000-0002-0476-5786
Salvà Casanovas, Antonio|||0000-0001-6328-3261
Rothenbacher, Dietrich|||0000-0002-3563-2791
Denkinger, Michael|||0000-0002-8097-060X
Stubbs, Brendon
author_role author
author2 Klenk, Jochen|||0000-0002-5987-447X
Brefka, Simone
Dallmeier, Dhayana|||0000-0003-3665-7023
Faehling, Kathrin
Roqué i Figuls, Marta|||0000-0003-0043-1364
Tully, Mark|||0000-0001-9710-4014
Giné-Garriga, Maria|||0000-0003-4449-3524
Caserotti, Paolo|||0000-0002-0476-5786
Salvà Casanovas, Antonio|||0000-0001-6328-3261
Rothenbacher, Dietrich|||0000-0002-3563-2791
Denkinger, Michael|||0000-0002-8097-060X
Stubbs, Brendon
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Older adults
Sedentary behaviour
Biomarker
topic Older adults
Sedentary behaviour
Biomarker
description Objective Pathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults. Methods Electronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with objective or subjective measures of SB, sample size ≥50, mean age ≥60 years and accelerometer wear time ≥3 days. Methodological quality was appraised with the CASP tool. The protocol was pre-specified (PROSPERO CRD42015023731). Results 12701 abstracts were retrieved, 275 full text articles further explored, from which 249 were excluded. In the final sample (26 articles) a total of 63 biomarkers were detected. Most investigated markers were: body mass index (BMI, n = 15), waist circumference (WC, n = 15), blood pressure (n = 11), triglycerides (n = 12) and high density lipoprotein (HDL, n = 15). Some inflammation markers were identified such as interleukin-6, C-reactive protein or tumor necrosis factor alpha. There was a lack of renal, muscle or bone biomarkers. Randomized controlled trials found a positive correlation for SB with BMI, neck circumference, fat mass, HbA1C, cholesterol and insulin levels, cohort studies additionally for WC, leptin, C-peptide, ApoA1 and Low density lipoprotein and a negative correlation for HDL. Conclusion Most studied biomarkers associated with SB were of cardiovascular or metabolic origin. There is a suggestion of a negative impact of SB on biomarkers but still a paucity of high quality investigations exist. Longitudinal studies with objectively measured SB are needed to further elucidate the pathophysiological pathways and possible associations of unexplored biomarkers.
publishDate 2017
dc.date.none.fl_str_mv 2
2017-01-01
2017
2017-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/257908
https://dx.doi.org/urn:doi:10.1016/j.arr.2016.12.002
url https://ddd.uab.cat/record/257908
https://dx.doi.org/urn:doi:10.1016/j.arr.2016.12.002
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 634270
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
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