CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia

Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN). We measured soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is shed from disease-associated microglia following cleavage of TREM2, in cerebrospinal fluid...

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Autores: van der Ende, Emma L.|||0000-0003-2570-8796, Morenas-Rodríguez, Estrella|||0000-0002-7591-6051, McMillan, Corey T.|||0000-0002-7581-6405, Grossman, Murray|||0000-0002-7447-6218, Irwin, David J.|||0000-0002-5599-5098, Sanchez-Valle, Raquel|||0000-0001-7750-896X, Graff, Caroline|||0000-0002-9949-2951, Vandenberghe, Rik|||0000-0001-6237-2502, Pijnenburg, Yolande|||0000-0003-2464-1905, Laforce, Robert Jr|||0000-0002-2031-490X, Le Ber, Isabelle|||0000-0002-2508-5181, Lleó, Alberto|||0000-0002-2568-5478, Haass, Christian|||0000-0002-4869-1627, Suárez-Calvet, Marc|||0000-0002-2993-569X, van Swieten, John Cornelis, Seelaar, Harro|||0000-0003-1989-7527
Tipo de documento: artigo
Data de publicação:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:271896
Acesso em linha:https://ddd.uab.cat/record/271896
https://dx.doi.org/urn:doi:10.1016/j.neurobiolaging.2021.02.024
Access Level:Acceso aberto
Palavra-chave:Frontotemporal dementia
Biomarker
Cerebrospinal fluid
Microglia
Strem2
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oai_identifier_str oai:ddd.uab.cat:271896
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network_name_str España
repository_id_str
spelling CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementiavan der Ende, Emma L.|||0000-0003-2570-8796Morenas-Rodríguez, Estrella|||0000-0002-7591-6051McMillan, Corey T.|||0000-0002-7581-6405Grossman, Murray|||0000-0002-7447-6218Irwin, David J.|||0000-0002-5599-5098Sanchez-Valle, Raquel|||0000-0001-7750-896XGraff, Caroline|||0000-0002-9949-2951Vandenberghe, Rik|||0000-0001-6237-2502Pijnenburg, Yolande|||0000-0003-2464-1905Laforce, Robert Jr|||0000-0002-2031-490XLe Ber, Isabelle|||0000-0002-2508-5181Lleó, Alberto|||0000-0002-2568-5478Haass, Christian|||0000-0002-4869-1627Suárez-Calvet, Marc|||0000-0002-2993-569Xvan Swieten, John CornelisSeelaar, Harro|||0000-0003-1989-7527Frontotemporal dementiaBiomarkerCerebrospinal fluidMicrogliaStrem2Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN). We measured soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is shed from disease-associated microglia following cleavage of TREM2, in cerebrospinal fluid of 34 presymptomatic and 35 symptomatic GRN mutation carriers, 6 presymptomatic and 32 symptomatic C9orf72 mutation carriers and 67 healthy noncarriers by ELISA. Although no group differences in sTREM2 levels were observed (GRN: symptomatic (median 5.2 ng/mL, interquartile range [3.9-9.2]) vs. presymptomatic (4.3 ng/mL [2.6-6.1]) vs. noncarriers (4.2 ng/mL [2.6-5.5]): p = 0.059; C9orf72: symptomatic (4.3 [2.9-7.0]) vs. presymptomatic (3.2 [2.2-4.2]) vs. noncarriers: p = 0.294), high levels were seen in a subset of GRN, but not C9orf72, mutation carriers, which might reflect differential TREM2-related microglial activation. Interestingly, 2 presymptomatic carriers with low sTREM2 levels developed symptoms after 1 year, whereas 2 with high levels became symptomatic after. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/271896https://dx.doi.org/urn:doi:10.1016/j.neurobiolaging.2021.02.024reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2718962026-06-06T12:50:31Z
dc.title.none.fl_str_mv CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
title CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
spellingShingle CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
van der Ende, Emma L.|||0000-0003-2570-8796
Frontotemporal dementia
Biomarker
Cerebrospinal fluid
Microglia
Strem2
title_short CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
title_full CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
title_fullStr CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
title_full_unstemmed CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
title_sort CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
dc.creator.none.fl_str_mv van der Ende, Emma L.|||0000-0003-2570-8796
Morenas-Rodríguez, Estrella|||0000-0002-7591-6051
McMillan, Corey T.|||0000-0002-7581-6405
Grossman, Murray|||0000-0002-7447-6218
Irwin, David J.|||0000-0002-5599-5098
Sanchez-Valle, Raquel|||0000-0001-7750-896X
Graff, Caroline|||0000-0002-9949-2951
Vandenberghe, Rik|||0000-0001-6237-2502
Pijnenburg, Yolande|||0000-0003-2464-1905
Laforce, Robert Jr|||0000-0002-2031-490X
Le Ber, Isabelle|||0000-0002-2508-5181
Lleó, Alberto|||0000-0002-2568-5478
Haass, Christian|||0000-0002-4869-1627
Suárez-Calvet, Marc|||0000-0002-2993-569X
van Swieten, John Cornelis
Seelaar, Harro|||0000-0003-1989-7527
author van der Ende, Emma L.|||0000-0003-2570-8796
author_facet van der Ende, Emma L.|||0000-0003-2570-8796
Morenas-Rodríguez, Estrella|||0000-0002-7591-6051
McMillan, Corey T.|||0000-0002-7581-6405
Grossman, Murray|||0000-0002-7447-6218
Irwin, David J.|||0000-0002-5599-5098
Sanchez-Valle, Raquel|||0000-0001-7750-896X
Graff, Caroline|||0000-0002-9949-2951
Vandenberghe, Rik|||0000-0001-6237-2502
Pijnenburg, Yolande|||0000-0003-2464-1905
Laforce, Robert Jr|||0000-0002-2031-490X
Le Ber, Isabelle|||0000-0002-2508-5181
Lleó, Alberto|||0000-0002-2568-5478
Haass, Christian|||0000-0002-4869-1627
Suárez-Calvet, Marc|||0000-0002-2993-569X
van Swieten, John Cornelis
Seelaar, Harro|||0000-0003-1989-7527
author_role author
author2 Morenas-Rodríguez, Estrella|||0000-0002-7591-6051
McMillan, Corey T.|||0000-0002-7581-6405
Grossman, Murray|||0000-0002-7447-6218
Irwin, David J.|||0000-0002-5599-5098
Sanchez-Valle, Raquel|||0000-0001-7750-896X
Graff, Caroline|||0000-0002-9949-2951
Vandenberghe, Rik|||0000-0001-6237-2502
Pijnenburg, Yolande|||0000-0003-2464-1905
Laforce, Robert Jr|||0000-0002-2031-490X
Le Ber, Isabelle|||0000-0002-2508-5181
Lleó, Alberto|||0000-0002-2568-5478
Haass, Christian|||0000-0002-4869-1627
Suárez-Calvet, Marc|||0000-0002-2993-569X
van Swieten, John Cornelis
Seelaar, Harro|||0000-0003-1989-7527
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Frontotemporal dementia
Biomarker
Cerebrospinal fluid
Microglia
Strem2
topic Frontotemporal dementia
Biomarker
Cerebrospinal fluid
Microglia
Strem2
description Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN). We measured soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is shed from disease-associated microglia following cleavage of TREM2, in cerebrospinal fluid of 34 presymptomatic and 35 symptomatic GRN mutation carriers, 6 presymptomatic and 32 symptomatic C9orf72 mutation carriers and 67 healthy noncarriers by ELISA. Although no group differences in sTREM2 levels were observed (GRN: symptomatic (median 5.2 ng/mL, interquartile range [3.9-9.2]) vs. presymptomatic (4.3 ng/mL [2.6-6.1]) vs. noncarriers (4.2 ng/mL [2.6-5.5]): p = 0.059; C9orf72: symptomatic (4.3 [2.9-7.0]) vs. presymptomatic (3.2 [2.2-4.2]) vs. noncarriers: p = 0.294), high levels were seen in a subset of GRN, but not C9orf72, mutation carriers, which might reflect differential TREM2-related microglial activation. Interestingly, 2 presymptomatic carriers with low sTREM2 levels developed symptoms after 1 year, whereas 2 with high levels became symptomatic after.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/271896
https://dx.doi.org/urn:doi:10.1016/j.neurobiolaging.2021.02.024
url https://ddd.uab.cat/record/271896
https://dx.doi.org/urn:doi:10.1016/j.neurobiolaging.2021.02.024
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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