Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17

Introduction: Seasonal influenza vaccination is widely recommended for people with risk factors, especially for people who are elderly. However, influenza vaccine effectiveness (IVE) varies year after year because of the variable antigenic composition of the circulating viruses and the vaccine compo...

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Autores: Mira-Iglesias, Ainara, Xavier Lopez-Labrador, F., Guglieri-Lopez, Beatriz, Tortajada-Girbes, Miguel, Baselga-Moreno, Victor, Cano, Laura, Mollar-Maseres, Juan, Carballido-Fernandez, Mario, Schwarz-Chavarri, German, Diez-Domingo, Javier, Puig-Barbera, Joan, Valencia Hosp Network Study
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p3039
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones3039
Access Level:acceso abierto
Palabra clave:*epidemiology
*hospitalisations
*influenza virus
*surveillance
*vaccine
*vaccine effectiveness
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spelling Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17Mira-Iglesias, AinaraXavier Lopez-Labrador, F.Guglieri-Lopez, BeatrizTortajada-Girbes, MiguelBaselga-Moreno, VictorCano, LauraMollar-Maseres, JuanCarballido-Fernandez, MarioSchwarz-Chavarri, GermanDiez-Domingo, JavierPuig-Barbera, JoanValencia Hosp Network Study*epidemiology*hospitalisations*influenza virus*surveillance*vaccine*vaccine effectivenessIntroduction: Seasonal influenza vaccination is widely recommended for people with risk factors, especially for people who are elderly. However, influenza vaccine effectiveness (IVE) varies year after year because of the variable antigenic composition of the circulating viruses and the vaccine composition. Methods: We summarise the results of IVE and the impact of previous vaccination among subjects 60 years of age and over in a multicentre prospective study in the Valencia Hospital Surveillance Network for the Study of Influenza and Respiratory Viruses Disease (VAHNSI) in Spain. We applied the test-negative design taking laboratory-confirmed influenza as outcome and vaccination status as exposure. Information about potential confounders was obtained from clinical registries or directly from patients. Results: Adjusted IVE was 19% (95% confidence interval (CI): -15 to 43). For patients vaccinated in the current season but not in the two previous seasons, effectiveness was 49% (95% CI: -20 to 78) and for patients vaccinated in the current and any of two previous seasons, effectiveness was 29% (95% CI: -3 to 52). For those patients not vaccinated in the current season but vaccinated in any of the two previous seasons, effectiveness was 53% (95% CI: 8 to 76). Conclusions: Our data show a low vaccine effectiveness for the 2016/17 influenza season.EUR CENTRE DIS PREVENTION & CONTROL2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones3039EurosurveillanceISSN: 1025496XISSNe: 15607917reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p30392026-06-12T10:20:37Z
dc.title.none.fl_str_mv Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17
title Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17
spellingShingle Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17
Mira-Iglesias, Ainara
*epidemiology
*hospitalisations
*influenza virus
*surveillance
*vaccine
*vaccine effectiveness
title_short Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17
title_full Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17
title_fullStr Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17
title_full_unstemmed Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17
title_sort Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016/17
dc.creator.none.fl_str_mv Mira-Iglesias, Ainara
Xavier Lopez-Labrador, F.
Guglieri-Lopez, Beatriz
Tortajada-Girbes, Miguel
Baselga-Moreno, Victor
Cano, Laura
Mollar-Maseres, Juan
Carballido-Fernandez, Mario
Schwarz-Chavarri, German
Diez-Domingo, Javier
Puig-Barbera, Joan
Valencia Hosp Network Study
author Mira-Iglesias, Ainara
author_facet Mira-Iglesias, Ainara
Xavier Lopez-Labrador, F.
Guglieri-Lopez, Beatriz
Tortajada-Girbes, Miguel
Baselga-Moreno, Victor
Cano, Laura
Mollar-Maseres, Juan
Carballido-Fernandez, Mario
Schwarz-Chavarri, German
Diez-Domingo, Javier
Puig-Barbera, Joan
Valencia Hosp Network Study
author_role author
author2 Xavier Lopez-Labrador, F.
Guglieri-Lopez, Beatriz
Tortajada-Girbes, Miguel
Baselga-Moreno, Victor
Cano, Laura
Mollar-Maseres, Juan
Carballido-Fernandez, Mario
Schwarz-Chavarri, German
Diez-Domingo, Javier
Puig-Barbera, Joan
Valencia Hosp Network Study
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv *epidemiology
*hospitalisations
*influenza virus
*surveillance
*vaccine
*vaccine effectiveness
topic *epidemiology
*hospitalisations
*influenza virus
*surveillance
*vaccine
*vaccine effectiveness
description Introduction: Seasonal influenza vaccination is widely recommended for people with risk factors, especially for people who are elderly. However, influenza vaccine effectiveness (IVE) varies year after year because of the variable antigenic composition of the circulating viruses and the vaccine composition. Methods: We summarise the results of IVE and the impact of previous vaccination among subjects 60 years of age and over in a multicentre prospective study in the Valencia Hospital Surveillance Network for the Study of Influenza and Respiratory Viruses Disease (VAHNSI) in Spain. We applied the test-negative design taking laboratory-confirmed influenza as outcome and vaccination status as exposure. Information about potential confounders was obtained from clinical registries or directly from patients. Results: Adjusted IVE was 19% (95% confidence interval (CI): -15 to 43). For patients vaccinated in the current season but not in the two previous seasons, effectiveness was 49% (95% CI: -20 to 78) and for patients vaccinated in the current and any of two previous seasons, effectiveness was 29% (95% CI: -3 to 52). For those patients not vaccinated in the current season but vaccinated in any of the two previous seasons, effectiveness was 53% (95% CI: 8 to 76). Conclusions: Our data show a low vaccine effectiveness for the 2016/17 influenza season.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones3039
url https://isabial.portalinvestigacion.com/publicaciones3039
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv EUR CENTRE DIS PREVENTION & CONTROL
publisher.none.fl_str_mv EUR CENTRE DIS PREVENTION & CONTROL
dc.source.none.fl_str_mv Eurosurveillance
ISSN: 1025496X
ISSNe: 15607917
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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