Altered nitrogen balance and decreased urea excretion in male rats fed cafeteria diet are related to arginine availability
Hyperlipidic diets limit glucose oxidation and favor amino acid preservation, hampering the elimination of excess dietary nitrogen and the catabolic utilization of amino acids.We analyzed whether reduced urea excretion was a consequence of higherNO; (nitrite,nitrate, and other derivatives) availabil...
| Autores: | , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/53473 |
| Acesso em linha: | https://hdl.handle.net/2445/53473 |
| Access Level: | acceso abierto |
| Palavra-chave: | Síndrome metabòlica Metabolisme Dieta Urea Nitrogen Aminoàcids Rates (Animals de laboratori) Metabolic syndrome Metabolism Diet Amino acids Rats as laboratory animals |
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Altered nitrogen balance and decreased urea excretion in male rats fed cafeteria diet are related to arginine availabilitySabater Martínez, DavidAgnelli, SilviaArriarán, SofíaFernández López, José AntonioRomero Romero, María del MarAlemany, Marià, 1946-Remesar Betlloch, XavierSíndrome metabòlicaMetabolismeDietaUreaNitrogenAminoàcidsRates (Animals de laboratori)Metabolic syndromeMetabolismDietAmino acidsRats as laboratory animalsHyperlipidic diets limit glucose oxidation and favor amino acid preservation, hampering the elimination of excess dietary nitrogen and the catabolic utilization of amino acids.We analyzed whether reduced urea excretion was a consequence of higherNO; (nitrite,nitrate, and other derivatives) availability caused by increased nitric oxide production in metabolic syndrome. Rats fed a cafeteria diet for 30 days had a higher intake and accumulation of amino acid nitrogen and lower urea excretion.There were no differences in plasma nitrate or nitrite. NO and creatinine excretion accounted for only a small part of total nitrogen excretion. Rats fed a cafeteria diet had higher plasma levels of glutamine, serine, threonine, glycine, and ornithinewhen comparedwith controls,whereas arginine was lower. Liver carbamoyl-phosphate synthetase I activity was higher in cafeteria diet-fed rats, but arginase I was lower. The high carbamoyl-phosphate synthetase activity and ornithine levels suggest activation of the urea cycle in cafeteria diet-fed rats, but low arginine levels point to a block in the urea cycle between ornithine and arginine, thereby preventing the elimination of excess nitrogen as urea. The ultimate consequence of this paradoxical block in the urea cycle seems to be the limitation of arginine production and/or availability.Hindawi Publishing Corporation2014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/53473Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1155/2014/959420BioMed Research International, 2014, vol. 2014http://dx.doi.org/10.1155/2014/959420cc-by (c) Sabater Martínez, David et al., 2014http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/534732026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Altered nitrogen balance and decreased urea excretion in male rats fed cafeteria diet are related to arginine availability |
| title |
Altered nitrogen balance and decreased urea excretion in male rats fed cafeteria diet are related to arginine availability |
| spellingShingle |
Altered nitrogen balance and decreased urea excretion in male rats fed cafeteria diet are related to arginine availability Sabater Martínez, David Síndrome metabòlica Metabolisme Dieta Urea Nitrogen Aminoàcids Rates (Animals de laboratori) Metabolic syndrome Metabolism Diet Amino acids Rats as laboratory animals |
| title_short |
Altered nitrogen balance and decreased urea excretion in male rats fed cafeteria diet are related to arginine availability |
| title_full |
Altered nitrogen balance and decreased urea excretion in male rats fed cafeteria diet are related to arginine availability |
| title_fullStr |
Altered nitrogen balance and decreased urea excretion in male rats fed cafeteria diet are related to arginine availability |
| title_full_unstemmed |
Altered nitrogen balance and decreased urea excretion in male rats fed cafeteria diet are related to arginine availability |
| title_sort |
Altered nitrogen balance and decreased urea excretion in male rats fed cafeteria diet are related to arginine availability |
| dc.creator.none.fl_str_mv |
Sabater Martínez, David Agnelli, Silvia Arriarán, Sofía Fernández López, José Antonio Romero Romero, María del Mar Alemany, Marià, 1946- Remesar Betlloch, Xavier |
| author |
Sabater Martínez, David |
| author_facet |
Sabater Martínez, David Agnelli, Silvia Arriarán, Sofía Fernández López, José Antonio Romero Romero, María del Mar Alemany, Marià, 1946- Remesar Betlloch, Xavier |
| author_role |
author |
| author2 |
Agnelli, Silvia Arriarán, Sofía Fernández López, José Antonio Romero Romero, María del Mar Alemany, Marià, 1946- Remesar Betlloch, Xavier |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Síndrome metabòlica Metabolisme Dieta Urea Nitrogen Aminoàcids Rates (Animals de laboratori) Metabolic syndrome Metabolism Diet Amino acids Rats as laboratory animals |
| topic |
Síndrome metabòlica Metabolisme Dieta Urea Nitrogen Aminoàcids Rates (Animals de laboratori) Metabolic syndrome Metabolism Diet Amino acids Rats as laboratory animals |
| description |
Hyperlipidic diets limit glucose oxidation and favor amino acid preservation, hampering the elimination of excess dietary nitrogen and the catabolic utilization of amino acids.We analyzed whether reduced urea excretion was a consequence of higherNO; (nitrite,nitrate, and other derivatives) availability caused by increased nitric oxide production in metabolic syndrome. Rats fed a cafeteria diet for 30 days had a higher intake and accumulation of amino acid nitrogen and lower urea excretion.There were no differences in plasma nitrate or nitrite. NO and creatinine excretion accounted for only a small part of total nitrogen excretion. Rats fed a cafeteria diet had higher plasma levels of glutamine, serine, threonine, glycine, and ornithinewhen comparedwith controls,whereas arginine was lower. Liver carbamoyl-phosphate synthetase I activity was higher in cafeteria diet-fed rats, but arginase I was lower. The high carbamoyl-phosphate synthetase activity and ornithine levels suggest activation of the urea cycle in cafeteria diet-fed rats, but low arginine levels point to a block in the urea cycle between ornithine and arginine, thereby preventing the elimination of excess nitrogen as urea. The ultimate consequence of this paradoxical block in the urea cycle seems to be the limitation of arginine production and/or availability. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2014 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/53473 |
| url |
https://hdl.handle.net/2445/53473 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: http://dx.doi.org/10.1155/2014/959420 BioMed Research International, 2014, vol. 2014 http://dx.doi.org/10.1155/2014/959420 |
| dc.rights.none.fl_str_mv |
cc-by (c) Sabater Martínez, David et al., 2014 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc-by (c) Sabater Martínez, David et al., 2014 http://creativecommons.org/licenses/by/3.0/es |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
| publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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1869425104866246656 |
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15,198674 |