Mutant prevention window for the less evolvable first-step mutant
Mutation rate for 2-DOS aminoglycoside resistance in the K88E strain (triangles, darker colors) compared with the ancestral strain (circles, lighter colors) across a gradient of lethal concentrations of amikacin (AMK, green), gentamicin (GEN, orange), kanamycin (KAN, blue), and tobramycin (TOB, pink...
| Autores: | , , , |
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| Tipo de recurso: | conjunto de datos |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:dnet:digitalcsic_::1c34f5808f897c1c5d480c6c467393f5 |
| Acceso en línea: | http://hdl.handle.net/10261/426203 |
| Access Level: | acceso abierto |
| Palabra clave: | Systems involving single Smaller effect sizes Promote evolutionary robustness Genotypes deviate markedly Genome sequencing reveals Electron transport chain Combat multidrug resistance Investigate whether common biophysics genetics microbiology biotechnology evolutionary biology ecology infectious diseases Biochemistry |
| Sumario: | Mutation rate for 2-DOS aminoglycoside resistance in the K88E strain (triangles, darker colors) compared with the ancestral strain (circles, lighter colors) across a gradient of lethal concentrations of amikacin (AMK, green), gentamicin (GEN, orange), kanamycin (KAN, blue), and tobramycin (TOB, pink). Antibiotic susceptibilities are shown as fold increases relative to the Minimal Inhibitory Concentration (MIC) of the ancestral strain. Values represent the mutation rate ± 95% confidence interval from three replicates. |
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