Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study

Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropometric, biochemical,...

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Autores: Escobedo-Monge, Marlene Fabiola, Barrado, Enrique, Parodi-Román, Joaquín, Escobedo Monge, María Antonieta, Torres-Hinojal, María, Marugán Miguelsanz, José Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Burgos (UBU)
Repositorio:Repositorio Institucional de la Universidad de Burgos (RIUBU)
OAI Identifier:oai:riubu.ubu.es:10259/11462
Acceso en línea:https://hdl.handle.net/10259/11462
Access Level:acceso abierto
Palabra clave:Hypocupremia
Hypercupremia
Inflammatory response
Risk of zinc deficiency
Serum zinc/copper ratio
Cobre-Metabolismo
Niños-Nutrición
Copper-Metabolism
Children-Nutrition
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spelling Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional StudyEscobedo-Monge, Marlene FabiolaBarrado, EnriqueParodi-Román, JoaquínEscobedo Monge, María AntonietaTorres-Hinojal, MaríaMarugán Miguelsanz, José ManuelHypocupremiaHypercupremiaInflammatory responseRisk of zinc deficiencySerum zinc/copper ratioCobre-MetabolismoNiños-NutriciónCopper-MetabolismChildren-NutritionCopper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropometric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaningfully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population.MDPI202620262021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/10259/11462reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)instname:Universidad de Burgos (UBU)InglésNutrients. 2021, V. 13, n. 10, 3578https://doi.org/10.3390/nu13103578Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riubu.ubu.es:10259/114622026-05-28T07:56:11Z
dc.title.none.fl_str_mv Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study
title Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study
spellingShingle Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study
Escobedo-Monge, Marlene Fabiola
Hypocupremia
Hypercupremia
Inflammatory response
Risk of zinc deficiency
Serum zinc/copper ratio
Cobre-Metabolismo
Niños-Nutrición
Copper-Metabolism
Children-Nutrition
title_short Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study
title_full Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study
title_fullStr Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study
title_full_unstemmed Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study
title_sort Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study
dc.creator.none.fl_str_mv Escobedo-Monge, Marlene Fabiola
Barrado, Enrique
Parodi-Román, Joaquín
Escobedo Monge, María Antonieta
Torres-Hinojal, María
Marugán Miguelsanz, José Manuel
author Escobedo-Monge, Marlene Fabiola
author_facet Escobedo-Monge, Marlene Fabiola
Barrado, Enrique
Parodi-Román, Joaquín
Escobedo Monge, María Antonieta
Torres-Hinojal, María
Marugán Miguelsanz, José Manuel
author_role author
author2 Barrado, Enrique
Parodi-Román, Joaquín
Escobedo Monge, María Antonieta
Torres-Hinojal, María
Marugán Miguelsanz, José Manuel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hypocupremia
Hypercupremia
Inflammatory response
Risk of zinc deficiency
Serum zinc/copper ratio
Cobre-Metabolismo
Niños-Nutrición
Copper-Metabolism
Children-Nutrition
topic Hypocupremia
Hypercupremia
Inflammatory response
Risk of zinc deficiency
Serum zinc/copper ratio
Cobre-Metabolismo
Niños-Nutrición
Copper-Metabolism
Children-Nutrition
description Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropometric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaningfully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population.
publishDate 2021
dc.date.none.fl_str_mv 2021
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10259/11462
url https://hdl.handle.net/10259/11462
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nutrients. 2021, V. 13, n. 10, 3578
https://doi.org/10.3390/nu13103578
dc.rights.none.fl_str_mv Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositorio Institucional de la Universidad de Burgos (RIUBU)
instname:Universidad de Burgos (UBU)
instname_str Universidad de Burgos (UBU)
reponame_str Repositorio Institucional de la Universidad de Burgos (RIUBU)
collection Repositorio Institucional de la Universidad de Burgos (RIUBU)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812455

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