Models of metaplasticity: a review of concepts
Part of hippocampal and cortical plasticity is characterized by synaptic modifications that depend on the joint activity of the pre- and post-synaptic neurons. To which extent those changes are determined by the exact timing and the average firing rates is still a matter of debate; this may vary fro...
| Autores: | , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/69444 |
| Acceso en línea: | http://hdl.handle.net/10230/69444 http://dx.doi.org/10.3389/fncom.2015.00138 |
| Access Level: | acceso abierto |
| Palabra clave: | Synaptic plasticity Metaplasticity Hebbian learning Homeostasis STDP |
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Models of metaplasticity: a review of conceptsYger, PierreGilson, MatthieuSynaptic plasticityMetaplasticityHebbian learningHomeostasisSTDPPart of hippocampal and cortical plasticity is characterized by synaptic modifications that depend on the joint activity of the pre- and post-synaptic neurons. To which extent those changes are determined by the exact timing and the average firing rates is still a matter of debate; this may vary from brain area to brain area, as well as across neuron types. However, it has been robustly observed both in vitro and in vivo that plasticity itself slowly adapts as a function of the dynamical context, a phenomena commonly referred to as metaplasticity. An alternative concept considers the regulation of groups of synapses with an objective at the neuronal level, for example, maintaining a given average firing rate. In that case, the change in the strength of a particular synapse of the group (e.g., due to Hebbian learning) affects others' strengths, which has been coined as heterosynaptic plasticity. Classically, Hebbian synaptic plasticity is paired in neuron network models with such mechanisms in order to stabilize the activity and/or the weight structure. Here, we present an oriented review that brings together various concepts from heterosynaptic plasticity to metaplasticity, and show how they interact with Hebbian-type learning. We focus on approaches that are nowadays used to incorporate those mechanisms to state-of-the-art models of spiking plasticity inspired by experimental observations in the hippocampus and cortex. Making the point that metaplasticity is an ubiquitous mechanism acting on top of classical Hebbian learning and promoting the stability of neural function over multiple timescales, we stress the need for incorporating it as a key element in the framework of plasticity models. Bridging theoretical and experimental results suggests a more functional role for metaplasticity mechanisms than simply stabilizing neural activity.Frontiers202520252015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/69444http://dx.doi.org/10.3389/fncom.2015.00138reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésFrontiers in Computational Neuroscience. 2015 Nov 10;9:20146© 2015 Yger and Gilson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/694442026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Models of metaplasticity: a review of concepts |
| title |
Models of metaplasticity: a review of concepts |
| spellingShingle |
Models of metaplasticity: a review of concepts Yger, Pierre Synaptic plasticity Metaplasticity Hebbian learning Homeostasis STDP |
| title_short |
Models of metaplasticity: a review of concepts |
| title_full |
Models of metaplasticity: a review of concepts |
| title_fullStr |
Models of metaplasticity: a review of concepts |
| title_full_unstemmed |
Models of metaplasticity: a review of concepts |
| title_sort |
Models of metaplasticity: a review of concepts |
| dc.creator.none.fl_str_mv |
Yger, Pierre Gilson, Matthieu |
| author |
Yger, Pierre |
| author_facet |
Yger, Pierre Gilson, Matthieu |
| author_role |
author |
| author2 |
Gilson, Matthieu |
| author2_role |
author |
| dc.subject.none.fl_str_mv |
Synaptic plasticity Metaplasticity Hebbian learning Homeostasis STDP |
| topic |
Synaptic plasticity Metaplasticity Hebbian learning Homeostasis STDP |
| description |
Part of hippocampal and cortical plasticity is characterized by synaptic modifications that depend on the joint activity of the pre- and post-synaptic neurons. To which extent those changes are determined by the exact timing and the average firing rates is still a matter of debate; this may vary from brain area to brain area, as well as across neuron types. However, it has been robustly observed both in vitro and in vivo that plasticity itself slowly adapts as a function of the dynamical context, a phenomena commonly referred to as metaplasticity. An alternative concept considers the regulation of groups of synapses with an objective at the neuronal level, for example, maintaining a given average firing rate. In that case, the change in the strength of a particular synapse of the group (e.g., due to Hebbian learning) affects others' strengths, which has been coined as heterosynaptic plasticity. Classically, Hebbian synaptic plasticity is paired in neuron network models with such mechanisms in order to stabilize the activity and/or the weight structure. Here, we present an oriented review that brings together various concepts from heterosynaptic plasticity to metaplasticity, and show how they interact with Hebbian-type learning. We focus on approaches that are nowadays used to incorporate those mechanisms to state-of-the-art models of spiking plasticity inspired by experimental observations in the hippocampus and cortex. Making the point that metaplasticity is an ubiquitous mechanism acting on top of classical Hebbian learning and promoting the stability of neural function over multiple timescales, we stress the need for incorporating it as a key element in the framework of plasticity models. Bridging theoretical and experimental results suggests a more functional role for metaplasticity mechanisms than simply stabilizing neural activity. |
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2015 |
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2015 2025 2025 |
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http://hdl.handle.net/10230/69444 http://dx.doi.org/10.3389/fncom.2015.00138 |
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http://hdl.handle.net/10230/69444 http://dx.doi.org/10.3389/fncom.2015.00138 |
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Inglés |
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Inglés |
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Frontiers in Computational Neuroscience. 2015 Nov 10;9:20146 |
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http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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