Genomic and functional conservation of lncRNAs: lessons from flies

Over the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically, and often lowly, expressed in certain tissues, cell types and biological contexts. Although lncRNAs participate in the...

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Detalhes bibliográficos
Autores: Camilleri Robles, Carlos, Amador, Raziel, Klein, Cecilia C., Guigó Serra, Roderic, Corominas Guiu, Montserrat, Ruiz-Romero, Marina
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/52677
Acesso em linha:http://hdl.handle.net/10230/52677
http://dx.doi.org/10.1007/s00335-021-09939-4
Access Level:acceso abierto
Palavra-chave:Comparative genomics
Conservation
Development
Drosophila melanogaster
Flies
LncRNAs
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spelling Genomic and functional conservation of lncRNAs: lessons from fliesCamilleri Robles, CarlosAmador, RazielKlein, Cecilia C.Guigó Serra, RodericCorominas Guiu, MontserratRuiz-Romero, MarinaComparative genomicsConservationDevelopmentDrosophila melanogasterFliesLncRNAsOver the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically, and often lowly, expressed in certain tissues, cell types and biological contexts. Although lncRNAs participate in the regulation of a wide variety of biological processes, including development and disease, most of their functions and mechanisms of action remain unknown. Poor conservation of the DNA sequences encoding for these transcripts makes the identification of lncRNAs orthologues among different species very challenging, especially between evolutionarily distant species such as flies and humans or mice. However, the functions of lncRNAs are unexpectedly preserved among different species supporting the idea that conservation occurs beyond DNA sequences and reinforcing the potential of characterising lncRNAs in animal models. In this review, we describe the features and roles of lncRNAs in the fruit fly Drosophila melanogaster, focusing on genomic and functional comparisons with human and mouse lncRNAs. We also discuss the current state of advances and limitations in the study of lncRNA conservation and future perspectives.This project was funded by Grants: BFU2015-67623-P and PGC2018-099763-B100, 2017SGR1455 from AGAUR (Generalitat de Catalunya) and a Grant from the Institució Catalana de Recerca i Estudis Avançats (via an ICREA Academia award) to M.C.; as well as support from the European Community under the FP7 programme (ERC-2011-AdG-294653-RNA-MAPS), 2U41 HG007234-05G from NIH/NHGRI (USA) and the Grant PGC2018-094017-B-I00 from the Spanish Ministerio de Ciencia, Innovación y Universidades to R.G.. C.C.-R. holds a predoctoral FPI contract from the Spanish Government (Ministerio de Ciencia e Innovación). R.A. is a predoctoral fellow of CONACYT, the “Becas al Extranjero” Program of Mexico.Springer202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/52677http://dx.doi.org/10.1007/s00335-021-09939-4reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésMamm Genome. 2022;33(2):328-42info:eu-repo/grantAgreement/EC/FP7/294653info:eu-repo/grantAgreement/ES/1PE/BFU2015-67623-Pinfo:eu-repo/grantAgreement/ES/2PE/PGC2018-099763-B100© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/526772026-06-12T07:21:37Z
dc.title.none.fl_str_mv Genomic and functional conservation of lncRNAs: lessons from flies
title Genomic and functional conservation of lncRNAs: lessons from flies
spellingShingle Genomic and functional conservation of lncRNAs: lessons from flies
Camilleri Robles, Carlos
Comparative genomics
Conservation
Development
Drosophila melanogaster
Flies
LncRNAs
title_short Genomic and functional conservation of lncRNAs: lessons from flies
title_full Genomic and functional conservation of lncRNAs: lessons from flies
title_fullStr Genomic and functional conservation of lncRNAs: lessons from flies
title_full_unstemmed Genomic and functional conservation of lncRNAs: lessons from flies
title_sort Genomic and functional conservation of lncRNAs: lessons from flies
dc.creator.none.fl_str_mv Camilleri Robles, Carlos
Amador, Raziel
Klein, Cecilia C.
Guigó Serra, Roderic
Corominas Guiu, Montserrat
Ruiz-Romero, Marina
author Camilleri Robles, Carlos
author_facet Camilleri Robles, Carlos
Amador, Raziel
Klein, Cecilia C.
Guigó Serra, Roderic
Corominas Guiu, Montserrat
Ruiz-Romero, Marina
author_role author
author2 Amador, Raziel
Klein, Cecilia C.
Guigó Serra, Roderic
Corominas Guiu, Montserrat
Ruiz-Romero, Marina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Comparative genomics
Conservation
Development
Drosophila melanogaster
Flies
LncRNAs
topic Comparative genomics
Conservation
Development
Drosophila melanogaster
Flies
LncRNAs
description Over the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically, and often lowly, expressed in certain tissues, cell types and biological contexts. Although lncRNAs participate in the regulation of a wide variety of biological processes, including development and disease, most of their functions and mechanisms of action remain unknown. Poor conservation of the DNA sequences encoding for these transcripts makes the identification of lncRNAs orthologues among different species very challenging, especially between evolutionarily distant species such as flies and humans or mice. However, the functions of lncRNAs are unexpectedly preserved among different species supporting the idea that conservation occurs beyond DNA sequences and reinforcing the potential of characterising lncRNAs in animal models. In this review, we describe the features and roles of lncRNAs in the fruit fly Drosophila melanogaster, focusing on genomic and functional comparisons with human and mouse lncRNAs. We also discuss the current state of advances and limitations in the study of lncRNA conservation and future perspectives.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/52677
http://dx.doi.org/10.1007/s00335-021-09939-4
url http://hdl.handle.net/10230/52677
http://dx.doi.org/10.1007/s00335-021-09939-4
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Mamm Genome. 2022;33(2):328-42
info:eu-repo/grantAgreement/EC/FP7/294653
info:eu-repo/grantAgreement/ES/1PE/BFU2015-67623-P
info:eu-repo/grantAgreement/ES/2PE/PGC2018-099763-B100
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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