A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial

The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benef...

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Autores: Farràs Mañé, Marta, Arranz, Sara, Carrión, Sílvia, Subirana Cachinero, Isaac, Muñoz-Aguayo, D., Blanchart, Gemma, Kool, Marjon, Solà, Rosa, Motilva, Maria-José, Escolà-Gil, Joan Carles, Rubió, Laura, Fernández-Castillejo, Sara, Pedret, Anna, Estruch, Ramón, Covas Planells, Maria Isabel, Fitó Colomer, Montserrat, Hernáez, Álvaro, Castañer, Olga
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/43896
Acceso en línea:http://hdl.handle.net/10230/43896
http://dx.doi.org/10.3390/nu11081732
Access Level:acceso abierto
Palabra clave:HDL cholesterol
Cholesterol efflux
Functional virgin olive oil
Olive oil phenolic compounds
Thyme phenolic compounds
Transcriptomics
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spelling A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trialFarràs Mañé, MartaArranz, SaraCarrión, SílviaSubirana Cachinero, IsaacMuñoz-Aguayo, D.Blanchart, GemmaKool, MarjonSolà, RosaMotilva, Maria-JoséEscolà-Gil, Joan CarlesRubió, LauraFernández-Castillejo, SaraPedret, AnnaEstruch, RamónCovas Planells, Maria IsabelFitó Colomer, MontserratHernáez, ÁlvaroCastañer, OlgaHDL cholesterolCholesterol effluxFunctional virgin olive oilOlive oil phenolic compoundsThyme phenolic compoundsTranscriptomicsThe consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benefits are not fully understood. Our aim was to determine whether these functional VOOs could enhance the expression of cholesterol efflux-related genes. In a randomized, double-blind, crossover, controlled trial, 22 hypercholesterolemic subjects ingested for three weeks 25 mL/day of: (1) a functional VOO enriched with olive oil PCs (500 mg/kg); (2) a functional VOO enriched with olive oil (250 mg/kg) and thyme PCs (250 mg/kg; FVOOT), and; (3) a natural VOO (olive oil PCs: 80 mg/kg, control intervention). We assessed whether these interventions improved the expression of cholesterol efflux-related genes in peripheral blood mononuclear cells by quantitative reverse-transcription polymerase chain reactions. The FVOOT intervention upregulated the expression of CYP27A1 (P = 0.041 and P = 0.053, versus baseline and the control intervention, respectively), CAV1 (P = 0.070, versus the control intervention), and LXRβ, RXRα, and PPARβ/δ (P = 0.005, P = 0.005, and P = 0.038, respectively, relative to the baseline). The consumption of a functional VOO enriched with olive oil and thyme PCs enhanced the expression of key cholesterol efflux regulators, such as CYP27A1 and nuclear receptor-related genes.This research was funded by: the Spanish Ministry of Economy and Competitiveness (AGL2009-13517-C03-01, AGL2012-40144-C03-01), the Instituto de Salud Carlos III (CB06/03/0028, CB07/08/0016, CD17/00122, CD17/00233, and JR17/00022), FEDER funds (CB06/03), and the Agència de Gestió d’Ajuts Universitaris i de Recerca (2014-SGR-240, 2017-SGR-522).MDPI202020202019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/43896http://dx.doi.org/10.3390/nu11081732reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/ES/3PN/AGL2009-13517-C03-01info:eu-repo/grantAgreement/ES/3PN/AGL2012-40144-C03-01Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/438962026-05-29T05:05:01Z
dc.title.none.fl_str_mv A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial
title A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial
spellingShingle A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial
Farràs Mañé, Marta
HDL cholesterol
Cholesterol efflux
Functional virgin olive oil
Olive oil phenolic compounds
Thyme phenolic compounds
Transcriptomics
title_short A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial
title_full A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial
title_fullStr A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial
title_full_unstemmed A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial
title_sort A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial
dc.creator.none.fl_str_mv Farràs Mañé, Marta
Arranz, Sara
Carrión, Sílvia
Subirana Cachinero, Isaac
Muñoz-Aguayo, D.
Blanchart, Gemma
Kool, Marjon
Solà, Rosa
Motilva, Maria-José
Escolà-Gil, Joan Carles
Rubió, Laura
Fernández-Castillejo, Sara
Pedret, Anna
Estruch, Ramón
Covas Planells, Maria Isabel
Fitó Colomer, Montserrat
Hernáez, Álvaro
Castañer, Olga
author Farràs Mañé, Marta
author_facet Farràs Mañé, Marta
Arranz, Sara
Carrión, Sílvia
Subirana Cachinero, Isaac
Muñoz-Aguayo, D.
Blanchart, Gemma
Kool, Marjon
Solà, Rosa
Motilva, Maria-José
Escolà-Gil, Joan Carles
Rubió, Laura
Fernández-Castillejo, Sara
Pedret, Anna
Estruch, Ramón
Covas Planells, Maria Isabel
Fitó Colomer, Montserrat
Hernáez, Álvaro
Castañer, Olga
author_role author
author2 Arranz, Sara
Carrión, Sílvia
Subirana Cachinero, Isaac
Muñoz-Aguayo, D.
Blanchart, Gemma
Kool, Marjon
Solà, Rosa
Motilva, Maria-José
Escolà-Gil, Joan Carles
Rubió, Laura
Fernández-Castillejo, Sara
Pedret, Anna
Estruch, Ramón
Covas Planells, Maria Isabel
Fitó Colomer, Montserrat
Hernáez, Álvaro
Castañer, Olga
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HDL cholesterol
Cholesterol efflux
Functional virgin olive oil
Olive oil phenolic compounds
Thyme phenolic compounds
Transcriptomics
topic HDL cholesterol
Cholesterol efflux
Functional virgin olive oil
Olive oil phenolic compounds
Thyme phenolic compounds
Transcriptomics
description The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) also improves HDL functions, but the gene expression changes behind these benefits are not fully understood. Our aim was to determine whether these functional VOOs could enhance the expression of cholesterol efflux-related genes. In a randomized, double-blind, crossover, controlled trial, 22 hypercholesterolemic subjects ingested for three weeks 25 mL/day of: (1) a functional VOO enriched with olive oil PCs (500 mg/kg); (2) a functional VOO enriched with olive oil (250 mg/kg) and thyme PCs (250 mg/kg; FVOOT), and; (3) a natural VOO (olive oil PCs: 80 mg/kg, control intervention). We assessed whether these interventions improved the expression of cholesterol efflux-related genes in peripheral blood mononuclear cells by quantitative reverse-transcription polymerase chain reactions. The FVOOT intervention upregulated the expression of CYP27A1 (P = 0.041 and P = 0.053, versus baseline and the control intervention, respectively), CAV1 (P = 0.070, versus the control intervention), and LXRβ, RXRα, and PPARβ/δ (P = 0.005, P = 0.005, and P = 0.038, respectively, relative to the baseline). The consumption of a functional VOO enriched with olive oil and thyme PCs enhanced the expression of key cholesterol efflux regulators, such as CYP27A1 and nuclear receptor-related genes.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/43896
http://dx.doi.org/10.3390/nu11081732
url http://hdl.handle.net/10230/43896
http://dx.doi.org/10.3390/nu11081732
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/ES/3PN/AGL2009-13517-C03-01
info:eu-repo/grantAgreement/ES/3PN/AGL2012-40144-C03-01
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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