Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease

In Alzheimer’s disease (AD), transgenic mouse models have established links between abnormalities in the retina and those in the brain. APPNL-F/NL-F is a murine, humanized AD model that replicates several pathological features observed in patients with AD. Research has focused on obtaining quantitat...

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Autores: Sánchez-Puebla Fernández, Lidia, Hoz Montañana, María Rosa De, García Martín, Elena Salobrar, Arias Vázquez, Alberto, González Jiménez, María, Ramírez Sebastián, Ana Isabel, Fernández Albarral, José, Matamoros Felipe, José Antonio, Elvira Hurtado, Lorena, Saido, Takaomi C, Saito, Takashi, Nieto Vaquero, Carmen, Cuartero Desviat, María Isabel, Moro Sánchez, María Ángeles, Salazar Corral, Juan José, López Cuenca, Inés, Ramírez Sebastián, José Manuel
Tipo de documento: artigo
Data de publicação:2024
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositório:Docta Complutense
Idioma:inglês
OAI Identifier:oai:docta.ucm.es:20.500.14352/109284
Acesso em linha:https://hdl.handle.net/20.500.14352/109284
Access Level:Acceso aberto
Palavra-chave:611.843
616.894-053.9
Alzheimer’s disease
APPNL/F-NF/L
C57BL/6J
OCT-SD
Retinal layer
Optica (Medicina)
Óptica y optometría
32 Ciencias Médicas
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spelling Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s DiseaseSánchez-Puebla Fernández, LidiaHoz Montañana, María Rosa DeGarcía Martín, Elena SalobrarArias Vázquez, AlbertoGonzález Jiménez, MaríaRamírez Sebastián, Ana IsabelFernández Albarral, JoséMatamoros Felipe, José AntonioElvira Hurtado, LorenaSaido, Takaomi CSaito, TakashiNieto Vaquero, CarmenCuartero Desviat, María IsabelMoro Sánchez, María ÁngelesSalazar Corral, Juan JoséLópez Cuenca, InésRamírez Sebastián, José Manuel611.843616.894-053.9Alzheimer’s diseaseAPPNL/F-NF/LC57BL/6JOCT-SDRetinal layerOptica (Medicina)Óptica y optometría32 Ciencias MédicasIn Alzheimer’s disease (AD), transgenic mouse models have established links between abnormalities in the retina and those in the brain. APPNL-F/NL-F is a murine, humanized AD model that replicates several pathological features observed in patients with AD. Research has focused on obtaining quantitative parameters from optical coherence tomography (OCT) in AD. The aim of this study was to analyze, in a transversal case-control study using manual retinal segmentation via SD-OCT, the changes occurring in the retinal layers of the APPNL/F-NF/L AD model in comparison to C57BL/6J mice (WT) at 6, 9, 12, 15, 17, and 20 months of age. The analysis focused on retinal thickness in RNFL-GCL, IPL, INL, OPL, and ONL based on the Early Treatment Diabetic Retinopathy Study (ETDRS) sectors. Both APPNL-F/NL-F-model and WT animals exhibited thickness changes at the time points studied. While WT showed significant changes in INL, OPL, and ONL, the AD model showed changes in all retinal layers analyzed. The APPNL-F/NL-F displayed significant thickness variations in the analyzed layers except for the IPL compared to related WT. These thickness changes closely resembled those found in humans during preclinical stages, as well as during mild and moderate AD stages, making this AD model behave more similarly to the disease in humans.MDPIUniversidad Complutense de Madrid20242024-07-2720242024-07-27journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/109284reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)InglésengMinisterio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 Research Network RETIBRAIN RED2018-102499-Topen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1092842026-06-02T12:44:21Z
dc.title.none.fl_str_mv Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease
title Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease
spellingShingle Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease
Sánchez-Puebla Fernández, Lidia
611.843
616.894-053.9
Alzheimer’s disease
APPNL/F-NF/L
C57BL/6J
OCT-SD
Retinal layer
Optica (Medicina)
Óptica y optometría
32 Ciencias Médicas
title_short Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease
title_full Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease
title_fullStr Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease
title_full_unstemmed Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease
title_sort Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer’s Disease
dc.creator.none.fl_str_mv Sánchez-Puebla Fernández, Lidia
Hoz Montañana, María Rosa De
García Martín, Elena Salobrar
Arias Vázquez, Alberto
González Jiménez, María
Ramírez Sebastián, Ana Isabel
Fernández Albarral, José
Matamoros Felipe, José Antonio
Elvira Hurtado, Lorena
Saido, Takaomi C
Saito, Takashi
Nieto Vaquero, Carmen
Cuartero Desviat, María Isabel
Moro Sánchez, María Ángeles
Salazar Corral, Juan José
López Cuenca, Inés
Ramírez Sebastián, José Manuel
author Sánchez-Puebla Fernández, Lidia
author_facet Sánchez-Puebla Fernández, Lidia
Hoz Montañana, María Rosa De
García Martín, Elena Salobrar
Arias Vázquez, Alberto
González Jiménez, María
Ramírez Sebastián, Ana Isabel
Fernández Albarral, José
Matamoros Felipe, José Antonio
Elvira Hurtado, Lorena
Saido, Takaomi C
Saito, Takashi
Nieto Vaquero, Carmen
Cuartero Desviat, María Isabel
Moro Sánchez, María Ángeles
Salazar Corral, Juan José
López Cuenca, Inés
Ramírez Sebastián, José Manuel
author_role author
author2 Hoz Montañana, María Rosa De
García Martín, Elena Salobrar
Arias Vázquez, Alberto
González Jiménez, María
Ramírez Sebastián, Ana Isabel
Fernández Albarral, José
Matamoros Felipe, José Antonio
Elvira Hurtado, Lorena
Saido, Takaomi C
Saito, Takashi
Nieto Vaquero, Carmen
Cuartero Desviat, María Isabel
Moro Sánchez, María Ángeles
Salazar Corral, Juan José
López Cuenca, Inés
Ramírez Sebastián, José Manuel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 611.843
616.894-053.9
Alzheimer’s disease
APPNL/F-NF/L
C57BL/6J
OCT-SD
Retinal layer
Optica (Medicina)
Óptica y optometría
32 Ciencias Médicas
topic 611.843
616.894-053.9
Alzheimer’s disease
APPNL/F-NF/L
C57BL/6J
OCT-SD
Retinal layer
Optica (Medicina)
Óptica y optometría
32 Ciencias Médicas
description In Alzheimer’s disease (AD), transgenic mouse models have established links between abnormalities in the retina and those in the brain. APPNL-F/NL-F is a murine, humanized AD model that replicates several pathological features observed in patients with AD. Research has focused on obtaining quantitative parameters from optical coherence tomography (OCT) in AD. The aim of this study was to analyze, in a transversal case-control study using manual retinal segmentation via SD-OCT, the changes occurring in the retinal layers of the APPNL/F-NF/L AD model in comparison to C57BL/6J mice (WT) at 6, 9, 12, 15, 17, and 20 months of age. The analysis focused on retinal thickness in RNFL-GCL, IPL, INL, OPL, and ONL based on the Early Treatment Diabetic Retinopathy Study (ETDRS) sectors. Both APPNL-F/NL-F-model and WT animals exhibited thickness changes at the time points studied. While WT showed significant changes in INL, OPL, and ONL, the AD model showed changes in all retinal layers analyzed. The APPNL-F/NL-F displayed significant thickness variations in the analyzed layers except for the IPL compared to related WT. These thickness changes closely resembled those found in humans during preclinical stages, as well as during mild and moderate AD stages, making this AD model behave more similarly to the disease in humans.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-07-27
2024
2024-07-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/109284
url https://hdl.handle.net/20.500.14352/109284
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 Research Network RETIBRAIN RED2018-102499-T
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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