FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their co-expression may predict FGFR-targeted therapy efficacy

[Background] Fibroblast growth factor receptor (FGFR)1 and FGFR4 have been associated with tumorigenesis in a variety of tumour types. As a therapeutic approach, their inhibition has been attempted in different types of malignancies, including lung cancer, and was initially focused on FGFR1-amplifie...

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Bibliographic Details
Authors: Quintanal-Villalonga, Álvaro, Ferrer, Irene, Guruceaga, Elizabeth, Cirauqui, Cristina, Marrugal, Ángela, Ojeda, Laura, García, Santiago, Zugazagoitia, Jon, Muñoz-Galván, Sandra, López-Ríos, Fernando, Montuenga, Luis, Vicent, Silvestre, Molina-Pinelo, Sonia, Carnero, Amancio, Paz-Ares, Luis
Format: article
Status:Published version
Publication Date:2020
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/235811
Online Access:http://hdl.handle.net/10261/235811
Access Level:Open access
Keyword:FGFR1
FGFR4
N-cadherin
Predictive biomarker
FGFR inhibitors
Description
Summary:[Background] Fibroblast growth factor receptor (FGFR)1 and FGFR4 have been associated with tumorigenesis in a variety of tumour types. As a therapeutic approach, their inhibition has been attempted in different types of malignancies, including lung cancer, and was initially focused on FGFR1-amplified tumours, though with limited success.

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