Role of sirtuins in ischemia-reperfusion injury

Ischemia-reperfusion injury (IRI) remains an unresolved and complicated situation in clinical practice, especially in the case of organ transplantation. Several factors contribute to its complexity; the depletion of energy during ischemia and the induction of oxidative stress during reperfusion init...

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Autores: Pantazi, Eirini, Zaouali, Mohamed A., Bejaoui, Mohamed, Folch-Puy, Emma, Abdennebi, Hassen B., Roselló-Catafau, Joan
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/114174
Acesso em linha:http://hdl.handle.net/10261/114174
Access Level:acceso abierto
Palavra-chave:Sirtuin 1
Sirtuin 3
Ischemia-reperfusion injury
Oxidative stress
Apoptosis
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spelling Role of sirtuins in ischemia-reperfusion injuryPantazi, EiriniZaouali, Mohamed A.Bejaoui, MohamedFolch-Puy, EmmaAbdennebi, Hassen B.Roselló-Catafau, JoanSirtuin 1Sirtuin 3Ischemia-reperfusion injuryOxidative stressApoptosisIschemia-reperfusion injury (IRI) remains an unresolved and complicated situation in clinical practice, especially in the case of organ transplantation. Several factors contribute to its complexity; the depletion of energy during ischemia and the induction of oxidative stress during reperfusion initiate a cascade of pathways that lead to cell death and finally to severe organ injury. Recently, the sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylases has gained increasing attention from researchers, due to their involvement in the modulation of a wide variety of cellular functions. There are seven mammalian sirtuins and, among them, the nuclear/cytoplasmic sirtuin 1 (SIRT1) and the mitochondrial sirtuin 3 (SIRT3) are ubiquitously expressed in many tissue types. Sirtuins are known to play major roles in protecting against cellular stress and in controlling metabolic pathways, which are key processes during IRI. In this review, we mainly focus on SIRT1 and SIRT3 and examine their role in modulating pathways against energy depletion during ischemia and their involvement in oxidative stress, apoptosis, microcirculatory stress and inflammation during reperfusion. We present evidence of the beneficial effects of sirtuins against IRI and emphasize the importance of developing new strategies by enhancing their action. © 2013 Baishideng Publishing Group Co., Limited. All rights reservedSupported by AGAUR, No. 2012FI_B00382, Generalitat de Catalunya, Barcelona, Spain, to Pantazi E; CSIC for the development program to Bejaoui M, No. I-COOP0005; The Fondo de Investigaciones Sanitarias, No. FIS PI12/00519Peer reviewedBaishideng Publishing GroupConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201520152013info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/114174reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3748/wjg.v19.i43.7594Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1141742026-05-22T06:33:51Z
dc.title.none.fl_str_mv Role of sirtuins in ischemia-reperfusion injury
title Role of sirtuins in ischemia-reperfusion injury
spellingShingle Role of sirtuins in ischemia-reperfusion injury
Pantazi, Eirini
Sirtuin 1
Sirtuin 3
Ischemia-reperfusion injury
Oxidative stress
Apoptosis
title_short Role of sirtuins in ischemia-reperfusion injury
title_full Role of sirtuins in ischemia-reperfusion injury
title_fullStr Role of sirtuins in ischemia-reperfusion injury
title_full_unstemmed Role of sirtuins in ischemia-reperfusion injury
title_sort Role of sirtuins in ischemia-reperfusion injury
dc.creator.none.fl_str_mv Pantazi, Eirini
Zaouali, Mohamed A.
Bejaoui, Mohamed
Folch-Puy, Emma
Abdennebi, Hassen B.
Roselló-Catafau, Joan
author Pantazi, Eirini
author_facet Pantazi, Eirini
Zaouali, Mohamed A.
Bejaoui, Mohamed
Folch-Puy, Emma
Abdennebi, Hassen B.
Roselló-Catafau, Joan
author_role author
author2 Zaouali, Mohamed A.
Bejaoui, Mohamed
Folch-Puy, Emma
Abdennebi, Hassen B.
Roselló-Catafau, Joan
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Sirtuin 1
Sirtuin 3
Ischemia-reperfusion injury
Oxidative stress
Apoptosis
topic Sirtuin 1
Sirtuin 3
Ischemia-reperfusion injury
Oxidative stress
Apoptosis
description Ischemia-reperfusion injury (IRI) remains an unresolved and complicated situation in clinical practice, especially in the case of organ transplantation. Several factors contribute to its complexity; the depletion of energy during ischemia and the induction of oxidative stress during reperfusion initiate a cascade of pathways that lead to cell death and finally to severe organ injury. Recently, the sirtuin family of nicotinamide adenine dinucleotide-dependent deacetylases has gained increasing attention from researchers, due to their involvement in the modulation of a wide variety of cellular functions. There are seven mammalian sirtuins and, among them, the nuclear/cytoplasmic sirtuin 1 (SIRT1) and the mitochondrial sirtuin 3 (SIRT3) are ubiquitously expressed in many tissue types. Sirtuins are known to play major roles in protecting against cellular stress and in controlling metabolic pathways, which are key processes during IRI. In this review, we mainly focus on SIRT1 and SIRT3 and examine their role in modulating pathways against energy depletion during ischemia and their involvement in oxidative stress, apoptosis, microcirculatory stress and inflammation during reperfusion. We present evidence of the beneficial effects of sirtuins against IRI and emphasize the importance of developing new strategies by enhancing their action. © 2013 Baishideng Publishing Group Co., Limited. All rights reserved
publishDate 2013
dc.date.none.fl_str_mv 2013
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/114174
url http://hdl.handle.net/10261/114174
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3748/wjg.v19.i43.7594
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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