Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional Risk

Background: A nationwide, prospective, multicenter, cohort study (the Disease-Related caloric-protein malnutrition EChOgraphy (DRECO) study) was designed to assess the usefulness of ultrasound of the rectus femoris for detecting sarcopenia in hospitalized patients at risk of malnutrition and to defi...

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Autores: Roman, DD, Almeida, JMG, Guerrero, DB, Rolo, GG, Martín, A, Martín, DP, García-Delgado, Y, Guirado-Peláez, P, Palmas, F, Pérez, CT, Olivares, MG, Jiménez, MM, Lesmes, IB, Teomiro, CMA, Baena, JMG, Romero, LAC, Prior-Sánchez, I, García-Luna, PP, Pacheco, MG, Martínez-Olmos, MA, Alabadí, B, Alcántara-Aragon, V, Milla, SP, Folgueras, TM, García, AM, Molina-Baena, B, Barragán, HR, Gómez, PRD, Fernández, MR, Portilla, AJ, López-Gómez, JJ, Martín, NP, Madrid, NM, Eguinoa, AZ, Fernández, CP, Guerrero, MJT, Aguado, MR, Gimeno, CV, Martínez, ADH, Rodríguez, MN, Hernández, NCI, Medina, MD, Navarro, IG, López, FJV, Fernández-Pombo, A, Olveira, G
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p18526
Acesso em linha:https://incliva.portalinvestigacion.com/publicaciones/18526
Access Level:acceso abierto
Palavra-chave:sarcopenia
nutritional ultrasound
ultrasound cut-off values
rectus femoris
malnutrition
nutritional risk
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spelling Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional RiskRoman, DDAlmeida, JMGGuerrero, DBRolo, GGMartín, AMartín, DPGarcía-Delgado, YGuirado-Peláez, PPalmas, FPérez, CTOlivares, MGJiménez, MMLesmes, IBTeomiro, CMABaena, JMGRomero, LACPrior-Sánchez, IGarcía-Luna, PPPacheco, MGMartínez-Olmos, MAAlabadí, BAlcántara-Aragon, VMilla, SPFolgueras, TMGarcía, AMMolina-Baena, BBarragán, HRGómez, PRDFernández, MRPortilla, AJLópez-Gómez, JJMartín, NPMadrid, NMEguinoa, AZFernández, CPGuerrero, MJTAguado, MRGimeno, CVMartínez, ADHRodríguez, MNHernández, NCIMedina, MDNavarro, IGLópez, FJVFernández-Pombo, AOlveira, Gsarcopenianutritional ultrasoundultrasound cut-off valuesrectus femorismalnutritionnutritional riskBackground: A nationwide, prospective, multicenter, cohort study (the Disease-Related caloric-protein malnutrition EChOgraphy (DRECO) study) was designed to assess the usefulness of ultrasound of the rectus femoris for detecting sarcopenia in hospitalized patients at risk of malnutrition and to define cut-off values of ultrasound measures. Methods: Patients at risk of malnutrition according to the Malnutrition Universal Screening Tool (MUST) underwent handgrip dynamometry, bioelectrical impedance analysis (BIA), a Timed Up and Go (TUG) test, and rectus femoris ultrasound studies. European Working Group on Sarcopenia in Older People (EWGSOP2) criteria were used to define categories of sarcopenia (at risk, probable, confirmed, severe). Receiver operating characteristic (ROC) and area under the curve (AUC) analyses were used to determine the optimal diagnostic sensitivity, specificity, and predictive values of cut-off points of the ultrasound measures for the detection of risk of sarcopenia and probable, confirmed, and severe sarcopenia. Results: A total of 1000 subjects were included and 991 of them (58.9% men, mean age 58.5 years) were evaluated. Risk of sarcopenia was detected in 9.6% patients, probable sarcopenia in 14%, confirmed sarcopenia in 9.7%, and severe sarcopenia in 3.9%, with significant differences in the distribution of groups between men and women (p < 0.0001). The cross-sectional area (CSA) of the rectus femoris showed a significantly positive correlation with body cell mass of BIA and handgrip strength, and a significant negative correlation with TUG. Cut-off values were similar within each category of sarcopenia, ranging between 2.40 cm(2) and 3.66 cm(2) for CSA, 32.57 mm and 40.21 mm for the X-axis, and 7.85 mm and 10.4 mm for the Y-axis. In general, these cut-off values showed high sensitivities, particularly for the categories of confirmed and severe sarcopenia, with male patients also showing better sensitivities than women. Conclusions: Sarcopenia in hospitalized patients at risk of malnutrition was high. Cut-off values for the better sensitivities and specificities of ultrasound measures of the rectus femoris are established. The use of ultrasound of the rectus femoris could be used for the prediction of sarcopenia and be useful to integrate nutritional study into real clinical practice.MDPI2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/18526NutrientsISSN: 20726643reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p185262026-06-07T16:35:31Z
dc.title.none.fl_str_mv Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional Risk
title Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional Risk
spellingShingle Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional Risk
Roman, DD
sarcopenia
nutritional ultrasound
ultrasound cut-off values
rectus femoris
malnutrition
nutritional risk
title_short Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional Risk
title_full Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional Risk
title_fullStr Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional Risk
title_full_unstemmed Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional Risk
title_sort Ultrasound Cut-Off Values for Rectus Femoris for Detecting Sarcopenia in Patients with Nutritional Risk
dc.creator.none.fl_str_mv Roman, DD
Almeida, JMG
Guerrero, DB
Rolo, GG
Martín, A
Martín, DP
García-Delgado, Y
Guirado-Peláez, P
Palmas, F
Pérez, CT
Olivares, MG
Jiménez, MM
Lesmes, IB
Teomiro, CMA
Baena, JMG
Romero, LAC
Prior-Sánchez, I
García-Luna, PP
Pacheco, MG
Martínez-Olmos, MA
Alabadí, B
Alcántara-Aragon, V
Milla, SP
Folgueras, TM
García, AM
Molina-Baena, B
Barragán, HR
Gómez, PRD
Fernández, MR
Portilla, AJ
López-Gómez, JJ
Martín, NP
Madrid, NM
Eguinoa, AZ
Fernández, CP
Guerrero, MJT
Aguado, MR
Gimeno, CV
Martínez, ADH
Rodríguez, MN
Hernández, NCI
Medina, MD
Navarro, IG
López, FJV
Fernández-Pombo, A
Olveira, G
author Roman, DD
author_facet Roman, DD
Almeida, JMG
Guerrero, DB
Rolo, GG
Martín, A
Martín, DP
García-Delgado, Y
Guirado-Peláez, P
Palmas, F
Pérez, CT
Olivares, MG
Jiménez, MM
Lesmes, IB
Teomiro, CMA
Baena, JMG
Romero, LAC
Prior-Sánchez, I
García-Luna, PP
Pacheco, MG
Martínez-Olmos, MA
Alabadí, B
Alcántara-Aragon, V
Milla, SP
Folgueras, TM
García, AM
Molina-Baena, B
Barragán, HR
Gómez, PRD
Fernández, MR
Portilla, AJ
López-Gómez, JJ
Martín, NP
Madrid, NM
Eguinoa, AZ
Fernández, CP
Guerrero, MJT
Aguado, MR
Gimeno, CV
Martínez, ADH
Rodríguez, MN
Hernández, NCI
Medina, MD
Navarro, IG
López, FJV
Fernández-Pombo, A
Olveira, G
author_role author
author2 Almeida, JMG
Guerrero, DB
Rolo, GG
Martín, A
Martín, DP
García-Delgado, Y
Guirado-Peláez, P
Palmas, F
Pérez, CT
Olivares, MG
Jiménez, MM
Lesmes, IB
Teomiro, CMA
Baena, JMG
Romero, LAC
Prior-Sánchez, I
García-Luna, PP
Pacheco, MG
Martínez-Olmos, MA
Alabadí, B
Alcántara-Aragon, V
Milla, SP
Folgueras, TM
García, AM
Molina-Baena, B
Barragán, HR
Gómez, PRD
Fernández, MR
Portilla, AJ
López-Gómez, JJ
Martín, NP
Madrid, NM
Eguinoa, AZ
Fernández, CP
Guerrero, MJT
Aguado, MR
Gimeno, CV
Martínez, ADH
Rodríguez, MN
Hernández, NCI
Medina, MD
Navarro, IG
López, FJV
Fernández-Pombo, A
Olveira, G
author2_role author
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author
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author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
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author
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author
dc.subject.none.fl_str_mv sarcopenia
nutritional ultrasound
ultrasound cut-off values
rectus femoris
malnutrition
nutritional risk
topic sarcopenia
nutritional ultrasound
ultrasound cut-off values
rectus femoris
malnutrition
nutritional risk
description Background: A nationwide, prospective, multicenter, cohort study (the Disease-Related caloric-protein malnutrition EChOgraphy (DRECO) study) was designed to assess the usefulness of ultrasound of the rectus femoris for detecting sarcopenia in hospitalized patients at risk of malnutrition and to define cut-off values of ultrasound measures. Methods: Patients at risk of malnutrition according to the Malnutrition Universal Screening Tool (MUST) underwent handgrip dynamometry, bioelectrical impedance analysis (BIA), a Timed Up and Go (TUG) test, and rectus femoris ultrasound studies. European Working Group on Sarcopenia in Older People (EWGSOP2) criteria were used to define categories of sarcopenia (at risk, probable, confirmed, severe). Receiver operating characteristic (ROC) and area under the curve (AUC) analyses were used to determine the optimal diagnostic sensitivity, specificity, and predictive values of cut-off points of the ultrasound measures for the detection of risk of sarcopenia and probable, confirmed, and severe sarcopenia. Results: A total of 1000 subjects were included and 991 of them (58.9% men, mean age 58.5 years) were evaluated. Risk of sarcopenia was detected in 9.6% patients, probable sarcopenia in 14%, confirmed sarcopenia in 9.7%, and severe sarcopenia in 3.9%, with significant differences in the distribution of groups between men and women (p < 0.0001). The cross-sectional area (CSA) of the rectus femoris showed a significantly positive correlation with body cell mass of BIA and handgrip strength, and a significant negative correlation with TUG. Cut-off values were similar within each category of sarcopenia, ranging between 2.40 cm(2) and 3.66 cm(2) for CSA, 32.57 mm and 40.21 mm for the X-axis, and 7.85 mm and 10.4 mm for the Y-axis. In general, these cut-off values showed high sensitivities, particularly for the categories of confirmed and severe sarcopenia, with male patients also showing better sensitivities than women. Conclusions: Sarcopenia in hospitalized patients at risk of malnutrition was high. Cut-off values for the better sensitivities and specificities of ultrasound measures of the rectus femoris are established. The use of ultrasound of the rectus femoris could be used for the prediction of sarcopenia and be useful to integrate nutritional study into real clinical practice.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/18526
url https://incliva.portalinvestigacion.com/publicaciones/18526
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Nutrients
ISSN: 20726643
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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