Lactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota

Probiotics have shown potential for their use in early life. This study aimed to investigate whether the administration of Lactobacillus fermentum CECT5716 during pregnancy and lactation periods impacts maternal and offspring plasma lipid profile, immune system and microbiota. Rats were supplemented...

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Detalles Bibliográficos
Autores: Azagra Boronat, Ignasi, Tres Oliver, Alba, Massot Cladera, Malen, Franch i Masferrer, Àngels, Castell, Margarida, Guardiola Ibarz, Francesc, Pérez-Cano, Francisco J., Rodríguez Lagunas, María José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/160177
Acceso en línea:https://hdl.handle.net/2445/160177
Access Level:acceso abierto
Palabra clave:Embaràs
Probiòtics
Alletament
Rosegadors
Àcids grassos
Microbiota
Pregnancy
Probiotics
Breastfeeding
Rodents
Fatty acids
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spelling Lactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and MicrobiotaAzagra Boronat, IgnasiTres Oliver, AlbaMassot Cladera, MalenFranch i Masferrer, ÀngelsCastell, MargaridaGuardiola Ibarz, FrancescPérez-Cano, Francisco J.Rodríguez Lagunas, María JoséEmbaràsProbiòticsAlletamentRosegadorsÀcids grassosMicrobiotaPregnancyProbioticsBreastfeedingRodentsFatty acidsMicrobiotaProbiotics have shown potential for their use in early life. This study aimed to investigate whether the administration of Lactobacillus fermentum CECT5716 during pregnancy and lactation periods impacts maternal and offspring plasma lipid profile, immune system and microbiota. Rats were supplemented with the probiotic during gestation and two weeks of lactation. After supplementation, although the microbiota composition was not affected, the probiotic strain was detected in all cecal contents of dams and in some of their pups. Dams showed reduced proportion of T cytotoxic cells in the mesenteric lymph nodes, modulation of intestinal cytokines (IL-10 and IL-12) and changes in plasma fatty acids (20:0, 22:0, 20:5 n-3, and 18:3 n-6). Pups showed changes in immunoglobulins (intestinal IgA and plasmatic IgG2a and IgG2c) and fatty acid profile (17:0, 22:0, and 18:2 n-6). Overall, Lactobacillus fermentum CECT5716 supplementation contributed to beneficially modulating the immune system of the mother and its offspring.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/160177Articles publicats en revistes (Bioquímica i Fisiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/cells9030575Cells, 2020, vol. 9, num. 3, p. 575https://doi.org/10.3390/cells9030575cc-by (c) Azagra Boronat, Ignasi et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1601772026-05-27T06:46:51Z
dc.title.none.fl_str_mv Lactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota
title Lactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota
spellingShingle Lactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota
Azagra Boronat, Ignasi
Embaràs
Probiòtics
Alletament
Rosegadors
Àcids grassos
Microbiota
Pregnancy
Probiotics
Breastfeeding
Rodents
Fatty acids
Microbiota
title_short Lactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota
title_full Lactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota
title_fullStr Lactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota
title_full_unstemmed Lactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota
title_sort Lactobacillus fermentum CECT5716 Supplementation in Rats During Pregnancy and Lactation Impacts Maternal and Offspring Lipid Profile, Immune System and Microbiota
dc.creator.none.fl_str_mv Azagra Boronat, Ignasi
Tres Oliver, Alba
Massot Cladera, Malen
Franch i Masferrer, Àngels
Castell, Margarida
Guardiola Ibarz, Francesc
Pérez-Cano, Francisco J.
Rodríguez Lagunas, María José
author Azagra Boronat, Ignasi
author_facet Azagra Boronat, Ignasi
Tres Oliver, Alba
Massot Cladera, Malen
Franch i Masferrer, Àngels
Castell, Margarida
Guardiola Ibarz, Francesc
Pérez-Cano, Francisco J.
Rodríguez Lagunas, María José
author_role author
author2 Tres Oliver, Alba
Massot Cladera, Malen
Franch i Masferrer, Àngels
Castell, Margarida
Guardiola Ibarz, Francesc
Pérez-Cano, Francisco J.
Rodríguez Lagunas, María José
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Embaràs
Probiòtics
Alletament
Rosegadors
Àcids grassos
Microbiota
Pregnancy
Probiotics
Breastfeeding
Rodents
Fatty acids
Microbiota
topic Embaràs
Probiòtics
Alletament
Rosegadors
Àcids grassos
Microbiota
Pregnancy
Probiotics
Breastfeeding
Rodents
Fatty acids
Microbiota
description Probiotics have shown potential for their use in early life. This study aimed to investigate whether the administration of Lactobacillus fermentum CECT5716 during pregnancy and lactation periods impacts maternal and offspring plasma lipid profile, immune system and microbiota. Rats were supplemented with the probiotic during gestation and two weeks of lactation. After supplementation, although the microbiota composition was not affected, the probiotic strain was detected in all cecal contents of dams and in some of their pups. Dams showed reduced proportion of T cytotoxic cells in the mesenteric lymph nodes, modulation of intestinal cytokines (IL-10 and IL-12) and changes in plasma fatty acids (20:0, 22:0, 20:5 n-3, and 18:3 n-6). Pups showed changes in immunoglobulins (intestinal IgA and plasmatic IgG2a and IgG2c) and fatty acid profile (17:0, 22:0, and 18:2 n-6). Overall, Lactobacillus fermentum CECT5716 supplementation contributed to beneficially modulating the immune system of the mother and its offspring.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/160177
url https://hdl.handle.net/2445/160177
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cells9030575
Cells, 2020, vol. 9, num. 3, p. 575
https://doi.org/10.3390/cells9030575
dc.rights.none.fl_str_mv cc-by (c) Azagra Boronat, Ignasi et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Azagra Boronat, Ignasi et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Fisiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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