The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are c...

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Autores: Lupu, Diana, Andersson, Patrik, Bornehag, Carl-Gustaf, Demeneix, Barbara, Fritsche, Ellen, Gennings, Chris, Lichtensteiger, Walter, Leist, Marcel, Leonards, Pim E. G., Ponsonby, Anne-Louise, Scholze, Martin, Testa, Giuseppe, Fernández-Tresguerres Hernández, Jesús Ángel, Westerink, Remco H. S., Zalc, Bernard, Rüegg, Joëlle
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/8198
Acceso en línea:https://hdl.handle.net/20.500.14352/8198
Access Level:acceso abierto
Palabra clave:endocrine-disrupting chemicals
developmental neurotoxicity
chemical testing
adverse outcome pathways
Endocrinología
Fisiología
3205.02 Endocrinología
2411 Fisiología Humana
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oai_identifier_str oai:docta.ucm.es:20.500.14352/8198
network_acronym_str ES
network_name_str España
repository_id_str
spelling The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental NeurotoxicityLupu, DianaAndersson, PatrikBornehag, Carl-GustafDemeneix, BarbaraFritsche, EllenGennings, ChrisLichtensteiger, WalterLeist, MarcelLeonards, Pim E. G.Ponsonby, Anne-LouiseScholze, MartinTesta, GiuseppeFernández-Tresguerres Hernández, Jesús ÁngelWesterink, Remco H. S.Zalc, BernardRüegg, Joëlleendocrine-disrupting chemicalsdevelopmental neurotoxicitychemical testingadverse outcome pathwaysEndocrinologíaFisiología3205.02 Endocrinología2411 Fisiología HumanaUbiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.MDPIUniversidad Complutense de Madrid20202020-06-0120202020-06-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/8198reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/81982026-06-02T12:44:21Z
dc.title.none.fl_str_mv The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
title The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
spellingShingle The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
Lupu, Diana
endocrine-disrupting chemicals
developmental neurotoxicity
chemical testing
adverse outcome pathways
Endocrinología
Fisiología
3205.02 Endocrinología
2411 Fisiología Humana
title_short The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
title_full The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
title_fullStr The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
title_full_unstemmed The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
title_sort The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity
dc.creator.none.fl_str_mv Lupu, Diana
Andersson, Patrik
Bornehag, Carl-Gustaf
Demeneix, Barbara
Fritsche, Ellen
Gennings, Chris
Lichtensteiger, Walter
Leist, Marcel
Leonards, Pim E. G.
Ponsonby, Anne-Louise
Scholze, Martin
Testa, Giuseppe
Fernández-Tresguerres Hernández, Jesús Ángel
Westerink, Remco H. S.
Zalc, Bernard
Rüegg, Joëlle
author Lupu, Diana
author_facet Lupu, Diana
Andersson, Patrik
Bornehag, Carl-Gustaf
Demeneix, Barbara
Fritsche, Ellen
Gennings, Chris
Lichtensteiger, Walter
Leist, Marcel
Leonards, Pim E. G.
Ponsonby, Anne-Louise
Scholze, Martin
Testa, Giuseppe
Fernández-Tresguerres Hernández, Jesús Ángel
Westerink, Remco H. S.
Zalc, Bernard
Rüegg, Joëlle
author_role author
author2 Andersson, Patrik
Bornehag, Carl-Gustaf
Demeneix, Barbara
Fritsche, Ellen
Gennings, Chris
Lichtensteiger, Walter
Leist, Marcel
Leonards, Pim E. G.
Ponsonby, Anne-Louise
Scholze, Martin
Testa, Giuseppe
Fernández-Tresguerres Hernández, Jesús Ángel
Westerink, Remco H. S.
Zalc, Bernard
Rüegg, Joëlle
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv endocrine-disrupting chemicals
developmental neurotoxicity
chemical testing
adverse outcome pathways
Endocrinología
Fisiología
3205.02 Endocrinología
2411 Fisiología Humana
topic endocrine-disrupting chemicals
developmental neurotoxicity
chemical testing
adverse outcome pathways
Endocrinología
Fisiología
3205.02 Endocrinología
2411 Fisiología Humana
description Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-06-01
2020
2020-06-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/8198
url https://hdl.handle.net/20.500.14352/8198
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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