Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome

Ribosomes and protein synthesis have been reported to be altered in the cerebral cortex at advanced stages of Alzheimer's disease (AD). Modifications in the hippocampus with disease progression have not been assessed. Sixty-seven cases including middle-aged (MA) and AD stages I-VI were analyzed...

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Autores: Hernández Ortega, Karina, Garcia Esparcia, Paula, Gil, Laura, Lucas, José J., Ferrer, Isidro (Ferrer Abizanda)
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/166403
Acceso en línea:https://hdl.handle.net/2445/166403
Access Level:acceso abierto
Palabra clave:Malaltia d'Alzheimer
Síntesi proteica
RNA
Histones
Alzheimer's disease
Protein synthesis
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spelling Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosomeHernández Ortega, KarinaGarcia Esparcia, PaulaGil, LauraLucas, José J.Ferrer, Isidro (Ferrer Abizanda)Malaltia d'AlzheimerSíntesi proteicaRNAHistonesAlzheimer's diseaseProtein synthesisRNAHistonesRibosomes and protein synthesis have been reported to be altered in the cerebral cortex at advanced stages of Alzheimer's disease (AD). Modifications in the hippocampus with disease progression have not been assessed. Sixty-seven cases including middle-aged (MA) and AD stages I-VI were analyzed. Nucleolar chaperones nucleolin, nucleophosmin and nucleoplasmin 3, and upstream binding transcription factor RNA polymerase I gene (UBTF) mRNAs are abnormally regulated and their protein levels reduced in AD. Histone modifications dimethylated histone H3K9 (H3K9me2) and acetylated histone H3K12 (H3K12ac) are decreased in CA1. Nuclear tau declines in CA1 and dentate gyrus (DG), and practically disappears in neurons with neurofibrillary tangles. Subunit 28 ribosomal RNA (28S rRNA) expression is altered in CA1 and DG in AD. Several genes encoding ribosomal proteins are abnormally regulated and protein levels of translation initiation factors eIF2 a, eIF3h and eIF5, and elongation factor eEF2, are altered in the CA1 region in AD. These findings show alterations in the protein synthesis machinery in AD involving the nucleolus, nucleus and ribosomes in the hippocampus in AD some of them starting at first stages (I-II) preceding neuron loss. These changes may lie behind reduced numbers of dendritic branches and reduced synapses of CA1 and DG neurons which cause hippocampal atrophyWiley2020202020162020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion13 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/166403Articles publicats en revistes (Patologia i Terapèutica Experimental)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1111/bpa.12335Brain Pathology, 2016, vol. 26, num. 5, p. 593-605https://doi.org/10.1111/bpa.12335(c) International Society of Neuropathology, 2016info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1664032026-05-29T05:05:01Z
dc.title.none.fl_str_mv Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome
title Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome
spellingShingle Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome
Hernández Ortega, Karina
Malaltia d'Alzheimer
Síntesi proteica
RNA
Histones
Alzheimer's disease
Protein synthesis
RNA
Histones
title_short Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome
title_full Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome
title_fullStr Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome
title_full_unstemmed Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome
title_sort Altered machinery of protein synthesis in Alzheimer's: from the nucleolus to the ribosome
dc.creator.none.fl_str_mv Hernández Ortega, Karina
Garcia Esparcia, Paula
Gil, Laura
Lucas, José J.
Ferrer, Isidro (Ferrer Abizanda)
author Hernández Ortega, Karina
author_facet Hernández Ortega, Karina
Garcia Esparcia, Paula
Gil, Laura
Lucas, José J.
Ferrer, Isidro (Ferrer Abizanda)
author_role author
author2 Garcia Esparcia, Paula
Gil, Laura
Lucas, José J.
Ferrer, Isidro (Ferrer Abizanda)
author2_role author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Síntesi proteica
RNA
Histones
Alzheimer's disease
Protein synthesis
RNA
Histones
topic Malaltia d'Alzheimer
Síntesi proteica
RNA
Histones
Alzheimer's disease
Protein synthesis
RNA
Histones
description Ribosomes and protein synthesis have been reported to be altered in the cerebral cortex at advanced stages of Alzheimer's disease (AD). Modifications in the hippocampus with disease progression have not been assessed. Sixty-seven cases including middle-aged (MA) and AD stages I-VI were analyzed. Nucleolar chaperones nucleolin, nucleophosmin and nucleoplasmin 3, and upstream binding transcription factor RNA polymerase I gene (UBTF) mRNAs are abnormally regulated and their protein levels reduced in AD. Histone modifications dimethylated histone H3K9 (H3K9me2) and acetylated histone H3K12 (H3K12ac) are decreased in CA1. Nuclear tau declines in CA1 and dentate gyrus (DG), and practically disappears in neurons with neurofibrillary tangles. Subunit 28 ribosomal RNA (28S rRNA) expression is altered in CA1 and DG in AD. Several genes encoding ribosomal proteins are abnormally regulated and protein levels of translation initiation factors eIF2 a, eIF3h and eIF5, and elongation factor eEF2, are altered in the CA1 region in AD. These findings show alterations in the protein synthesis machinery in AD involving the nucleolus, nucleus and ribosomes in the hippocampus in AD some of them starting at first stages (I-II) preceding neuron loss. These changes may lie behind reduced numbers of dendritic branches and reduced synapses of CA1 and DG neurons which cause hippocampal atrophy
publishDate 2016
dc.date.none.fl_str_mv 2016
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/166403
url https://hdl.handle.net/2445/166403
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1111/bpa.12335
Brain Pathology, 2016, vol. 26, num. 5, p. 593-605
https://doi.org/10.1111/bpa.12335
dc.rights.none.fl_str_mv (c) International Society of Neuropathology, 2016
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) International Society of Neuropathology, 2016
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Patologia i Terapèutica Experimental)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.223283

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