Supramolecular chemical biology: designed receptors and dynamic chemical systems

Supramolecular chemistry focuses on the study of species joined by non-covalent interactions, and therefore on dynamic and relatively ill-defined structures. Despite being a well-developed field, it has to face important challenges when dealing with the selective recognition of biomolecules in highl...

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Detalles Bibliográficos
Autor: Alfonso, Ignacio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/366761
Acceso en línea:http://hdl.handle.net/10261/366761
https://api.elsevier.com/content/abstract/scopus_id/85201111450
Access Level:acceso abierto
Palabra clave:Supramolecular chemistry
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling Supramolecular chemical biology: designed receptors and dynamic chemical systemsAlfonso, IgnacioSupramolecular chemistryhttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesSupramolecular chemistry focuses on the study of species joined by non-covalent interactions, and therefore on dynamic and relatively ill-defined structures. Despite being a well-developed field, it has to face important challenges when dealing with the selective recognition of biomolecules in highly competitive biomimetic media. However, supramolecular interactions reside at the core of chemical biology systems, since many processes in nature are governed by weak, non-covalent, strongly dynamic contacts. Therefore, there is a natural connection between these two research fields, which are not frequently related or share interests. In this feature article, I will highlight our most recent results in the molecular recognition of biologically relevant species, following different conceptual approaches from the most conventional design of elaborated receptors to the less popular dynamic combinatorial chemistry methodology. Selected illustrative examples from other groups will be also included. The discussion has been focused mainly on systems with potential biomedical applications.I wish to thank all the past and current members of the group, especially those who have contributed to the development of this chemistry and appear as co-authors in the corresponding cited references from our group. Far from being an exhaustive revision of the literature in this emerging field, I apologize beforehand to those authors who can feel excluded from the references cited in this Feature Article. Financial support from the Spanish Research Agency within the Spanish Ministry of Science, Innovation and Universities (PID2021-128411NB-I00, MCIU/AEI/10.13039/501100011033, and FEDER/EU) is gratefully acknowledged.Peer reviewedRoyal Society of Chemistry (UK)Ministerio de Ciencia y Tecnología (España)0000-0003-0678-0362Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/366761https://api.elsevier.com/content/abstract/scopus_id/85201111450reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MCIU/AEI/10.13039Chemical communications (Cambridge, England)DOI https://doi.org/10.1039/D4CC03163FSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3667612026-05-22T06:33:51Z
dc.title.none.fl_str_mv Supramolecular chemical biology: designed receptors and dynamic chemical systems
title Supramolecular chemical biology: designed receptors and dynamic chemical systems
spellingShingle Supramolecular chemical biology: designed receptors and dynamic chemical systems
Alfonso, Ignacio
Supramolecular chemistry
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Supramolecular chemical biology: designed receptors and dynamic chemical systems
title_full Supramolecular chemical biology: designed receptors and dynamic chemical systems
title_fullStr Supramolecular chemical biology: designed receptors and dynamic chemical systems
title_full_unstemmed Supramolecular chemical biology: designed receptors and dynamic chemical systems
title_sort Supramolecular chemical biology: designed receptors and dynamic chemical systems
dc.creator.none.fl_str_mv Alfonso, Ignacio
author Alfonso, Ignacio
author_facet Alfonso, Ignacio
author_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia y Tecnología (España)
0000-0003-0678-0362
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Supramolecular chemistry
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Supramolecular chemistry
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description Supramolecular chemistry focuses on the study of species joined by non-covalent interactions, and therefore on dynamic and relatively ill-defined structures. Despite being a well-developed field, it has to face important challenges when dealing with the selective recognition of biomolecules in highly competitive biomimetic media. However, supramolecular interactions reside at the core of chemical biology systems, since many processes in nature are governed by weak, non-covalent, strongly dynamic contacts. Therefore, there is a natural connection between these two research fields, which are not frequently related or share interests. In this feature article, I will highlight our most recent results in the molecular recognition of biologically relevant species, following different conceptual approaches from the most conventional design of elaborated receptors to the less popular dynamic combinatorial chemistry methodology. Selected illustrative examples from other groups will be also included. The discussion has been focused mainly on systems with potential biomedical applications.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/366761
https://api.elsevier.com/content/abstract/scopus_id/85201111450
url http://hdl.handle.net/10261/366761
https://api.elsevier.com/content/abstract/scopus_id/85201111450
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MCIU/AEI/10.13039
Chemical communications (Cambridge, England)
DOI https://doi.org/10.1039/D4CC03163F
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Royal Society of Chemistry (UK)
publisher.none.fl_str_mv Royal Society of Chemistry (UK)
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