Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection

Silica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties. Moreover, the mesoporous nature of these materials makes them sui...

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Autores: Polo, Lorena, Gómez Cerezo, María Natividad, Vivancos, Jose Luis, Sancenón, Félix, Arcos Navarrete, Daniel, Vallet Regí, María Dulce Nombre, Martínez Máñez, Ramón
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:español
OAI Identifier:oai:docta.ucm.es:20.500.14352/17583
Acceso en línea:https://hdl.handle.net/20.500.14352/17583
Access Level:acceso abierto
Palabra clave:66
546
615.46
Biomaterials Controlled release Gated mesoporous bioactive glasses
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3312 Tecnología de Materiales
2303 Química Inorgánica
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spelling Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infectionPolo, LorenaGómez Cerezo, María NatividadVivancos, Jose LuisSancenón, FélixArcos Navarrete, DanielVallet Regí, María Dulce NombreMartínez Máñez, Ramón66546615.46Biomaterials Controlled release Gated mesoporous bioactive glassesMaterialesQuímica inorgánica (Química)3312 Tecnología de Materiales2303 Química InorgánicaSilica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties. Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. In this work, we have developed innovative nanodevices based on the implementation of adenosine triphosphate (ATP) and e-poly-l-lysine molecular gates using a mesoporous bioglass as an inorganic support. The systems have been previously proved to work properly with a fluorescence probe and subsequently with an antibiotic(levofloxacin) and an antitumoral drug(doxorubicin). The bioactivity of the prepared materials has also been tested, giving promising results. Finally, in vitro cell culture studies have been carried out; demonstrating that this gated devices can provide useful approaches for bone cancer and bone infection treatments. Statement of Significance Molecular-gated materials have recently been drawing attention due to their applications in fields as biomedicine and molecular recognition. For the first time as we are aware, we report herein a new enzymatic responsive molecular-gated device consisting in a mesoporous bioactive glass support implemented with two different molecular gates. Both controlled drug delivery properties and apatite-like phase formation ability of the device have been demonstrated, getting promising results. This approach opens up the possibility of developing new stimuli-responsive tailored biomaterials for bone cancer and infection treatments as well as regenerative bone grafts.ElsevierUniversidad Complutense de Madrid20162016-12-0820162016-12-08journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/17583reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Españolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/175832026-06-02T12:44:21Z
dc.title.none.fl_str_mv Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
title Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
spellingShingle Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
Polo, Lorena
66
546
615.46
Biomaterials Controlled release Gated mesoporous bioactive glasses
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
title_short Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
title_full Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
title_fullStr Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
title_full_unstemmed Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
title_sort Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
dc.creator.none.fl_str_mv Polo, Lorena
Gómez Cerezo, María Natividad
Vivancos, Jose Luis
Sancenón, Félix
Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
Martínez Máñez, Ramón
author Polo, Lorena
author_facet Polo, Lorena
Gómez Cerezo, María Natividad
Vivancos, Jose Luis
Sancenón, Félix
Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
Martínez Máñez, Ramón
author_role author
author2 Gómez Cerezo, María Natividad
Vivancos, Jose Luis
Sancenón, Félix
Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
Martínez Máñez, Ramón
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 66
546
615.46
Biomaterials Controlled release Gated mesoporous bioactive glasses
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
topic 66
546
615.46
Biomaterials Controlled release Gated mesoporous bioactive glasses
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
description Silica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties. Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. In this work, we have developed innovative nanodevices based on the implementation of adenosine triphosphate (ATP) and e-poly-l-lysine molecular gates using a mesoporous bioglass as an inorganic support. The systems have been previously proved to work properly with a fluorescence probe and subsequently with an antibiotic(levofloxacin) and an antitumoral drug(doxorubicin). The bioactivity of the prepared materials has also been tested, giving promising results. Finally, in vitro cell culture studies have been carried out; demonstrating that this gated devices can provide useful approaches for bone cancer and bone infection treatments. Statement of Significance Molecular-gated materials have recently been drawing attention due to their applications in fields as biomedicine and molecular recognition. For the first time as we are aware, we report herein a new enzymatic responsive molecular-gated device consisting in a mesoporous bioactive glass support implemented with two different molecular gates. Both controlled drug delivery properties and apatite-like phase formation ability of the device have been demonstrated, getting promising results. This approach opens up the possibility of developing new stimuli-responsive tailored biomaterials for bone cancer and infection treatments as well as regenerative bone grafts.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-12-08
2016
2016-12-08
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/17583
url https://hdl.handle.net/20.500.14352/17583
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,228081

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