Comprehensive Observational Study in a Large Cohort of Asthma Patients after Adding LAMA to ICS/LABA

Adding LAMA to LABA/ICS is recommended to improve control in patients with persistent asthma. This observational, retrospective, before-and-after study considered patients diagnosed with asthma who started LABA/ICS + LAMA treatment (triple therapy, TT) between 1 January 2017 and 31 December 2018 and...

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Autores: Plaza, Vicente|||0000-0003-2567-5496, Domínguez-Ortega, Javier|||0000-0002-5397-2327, González-Segura Alsina, Diego, Lo Re, Daniele|||0000-0002-6068-5975, Sicras-Mainar, Antoni
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:296653
Acesso em linha:https://ddd.uab.cat/record/296653
https://dx.doi.org/urn:doi:10.3390/ph16111609
Access Level:acceso abierto
Palavra-chave:Asthma
Costs
Dual therapy
Exacerbations
Long-acting muscarinic antagonists
Triple therapy
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spelling Comprehensive Observational Study in a Large Cohort of Asthma Patients after Adding LAMA to ICS/LABAPlaza, Vicente|||0000-0003-2567-5496Domínguez-Ortega, Javier|||0000-0002-5397-2327González-Segura Alsina, DiegoLo Re, Daniele|||0000-0002-6068-5975Sicras-Mainar, AntoniAsthmaCostsDual therapyExacerbationsLong-acting muscarinic antagonistsTriple therapyAdding LAMA to LABA/ICS is recommended to improve control in patients with persistent asthma. This observational, retrospective, before-and-after study considered patients diagnosed with asthma who started LABA/ICS + LAMA treatment (triple therapy, TT) between 1 January 2017 and 31 December 2018 and had been treated with LABA/ICS (dual therapy, DT) in the year before. Changes in lung function and exacerbation rates, healthcare resource utilization, and healthcare and non-healthcare costs (€2019) were estimated in patients with asthma in clinical practices in Spain. Data from computerized medical records from seven Spanish regions were collected ±1 year of LAMA addition. 4740 patients (64.1 years old [SD: 16.3]) were included. TT reduced the incidence of exacerbations by 16.7% (p < 0.044) and the number of patients with exacerbations by 8.5% (p < 0.001) compared to previous DT. The rate of patients with severe exacerbations requiring systemic corticosteroids and their hospitalization rates significantly decreased by 22.5% and 29.5%. TT significantly improved FEV, FVC, and FEV/FVC, saving €571/patient for society. Younger patients with asthma (18-44 years old) and patients with severe asthma (FEV < 60%) performed better upon the initiation of TT. TT reduced asthma exacerbations, improved lung function and reduced healthcare costs vs. DT, particularly in patients requiring systemic corticosteroids to treat severe exacerbations.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/296653https://dx.doi.org/urn:doi:10.3390/ph16111609reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2966532026-06-06T12:50:31Z
dc.title.none.fl_str_mv Comprehensive Observational Study in a Large Cohort of Asthma Patients after Adding LAMA to ICS/LABA
title Comprehensive Observational Study in a Large Cohort of Asthma Patients after Adding LAMA to ICS/LABA
spellingShingle Comprehensive Observational Study in a Large Cohort of Asthma Patients after Adding LAMA to ICS/LABA
Plaza, Vicente|||0000-0003-2567-5496
Asthma
Costs
Dual therapy
Exacerbations
Long-acting muscarinic antagonists
Triple therapy
title_short Comprehensive Observational Study in a Large Cohort of Asthma Patients after Adding LAMA to ICS/LABA
title_full Comprehensive Observational Study in a Large Cohort of Asthma Patients after Adding LAMA to ICS/LABA
title_fullStr Comprehensive Observational Study in a Large Cohort of Asthma Patients after Adding LAMA to ICS/LABA
title_full_unstemmed Comprehensive Observational Study in a Large Cohort of Asthma Patients after Adding LAMA to ICS/LABA
title_sort Comprehensive Observational Study in a Large Cohort of Asthma Patients after Adding LAMA to ICS/LABA
dc.creator.none.fl_str_mv Plaza, Vicente|||0000-0003-2567-5496
Domínguez-Ortega, Javier|||0000-0002-5397-2327
González-Segura Alsina, Diego
Lo Re, Daniele|||0000-0002-6068-5975
Sicras-Mainar, Antoni
author Plaza, Vicente|||0000-0003-2567-5496
author_facet Plaza, Vicente|||0000-0003-2567-5496
Domínguez-Ortega, Javier|||0000-0002-5397-2327
González-Segura Alsina, Diego
Lo Re, Daniele|||0000-0002-6068-5975
Sicras-Mainar, Antoni
author_role author
author2 Domínguez-Ortega, Javier|||0000-0002-5397-2327
González-Segura Alsina, Diego
Lo Re, Daniele|||0000-0002-6068-5975
Sicras-Mainar, Antoni
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Asthma
Costs
Dual therapy
Exacerbations
Long-acting muscarinic antagonists
Triple therapy
topic Asthma
Costs
Dual therapy
Exacerbations
Long-acting muscarinic antagonists
Triple therapy
description Adding LAMA to LABA/ICS is recommended to improve control in patients with persistent asthma. This observational, retrospective, before-and-after study considered patients diagnosed with asthma who started LABA/ICS + LAMA treatment (triple therapy, TT) between 1 January 2017 and 31 December 2018 and had been treated with LABA/ICS (dual therapy, DT) in the year before. Changes in lung function and exacerbation rates, healthcare resource utilization, and healthcare and non-healthcare costs (€2019) were estimated in patients with asthma in clinical practices in Spain. Data from computerized medical records from seven Spanish regions were collected ±1 year of LAMA addition. 4740 patients (64.1 years old [SD: 16.3]) were included. TT reduced the incidence of exacerbations by 16.7% (p < 0.044) and the number of patients with exacerbations by 8.5% (p < 0.001) compared to previous DT. The rate of patients with severe exacerbations requiring systemic corticosteroids and their hospitalization rates significantly decreased by 22.5% and 29.5%. TT significantly improved FEV, FVC, and FEV/FVC, saving €571/patient for society. Younger patients with asthma (18-44 years old) and patients with severe asthma (FEV < 60%) performed better upon the initiation of TT. TT reduced asthma exacerbations, improved lung function and reduced healthcare costs vs. DT, particularly in patients requiring systemic corticosteroids to treat severe exacerbations.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/296653
https://dx.doi.org/urn:doi:10.3390/ph16111609
url https://ddd.uab.cat/record/296653
https://dx.doi.org/urn:doi:10.3390/ph16111609
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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